Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Danielle L. Champagne"'
Publikováno v:
McGill Journal of Medicine, Vol 4, Iss 1 (2020)
The ε4 allele of apolipoprotein E (apoE) is an important risk factor for Alzheimer's disease (AD), however, it is not required nor sufficient to cause the disease on its own. Herpes viruses cause acute and chronic diseases of the central nervous sys
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20037 (2011)
BACKGROUND: In humans, ethanol exposure during pregnancy causes a spectrum of developmental defects (fetal alcohol syndrome or FAS). Individuals vary in phenotypic expression. Zebrafish embryos develop FAS-like features after ethanol exposure. In thi
Externí odkaz:
https://doaj.org/article/385f7a28db3a43769102d741d5c26e20
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5167 (2009)
Maternal licking and grooming (LG) exerts profound influence on hippocampal development and function in the offspring. However, little information is available on the effects of variations in maternal care on other brain regions. Here we examined the
Externí odkaz:
https://doaj.org/article/8f9843f608a74594a30b8c35c429516f
Publikováno v:
Wound Repair and Regeneration. 23:855-865
This study assessed the lasting impact of dexamethasone (DEX) exposure during early development on tissue repair capacity at later life stages (5, 14, and 24 days post fertilization [dpf]) in zebrafish larvae. Using the caudal fin amputation model, w
Autor:
Frank van der Kooy, Mian Yahya Mushtaq, Young Hae Choi, Robert Verpoorte, Danielle L. Champagne, Rosilene M. Marçal
Publikováno v:
Planta Medica. 80:1227-1233
We applied an acute stress model to zebra fish in order to measure the changes in the metabolome due to biological stress. This was done by submitting the fish to fifteen minutes of acute confinement (netting) stress, and then five minutes for the op
Publikováno v:
Behavioural Brain Research. 228:367-374
One of the most commonly used behavioral endpoints measured in preclinical studies using rodent models is thigmotaxis (or "wall-hugging"). Thigmotaxis is a well-validated index of anxiety in animals and humans. While assays measuring thigmotaxis in a
Publikováno v:
Behavioural Brain Research. 222:15-25
The light/dark preference test is commonly used to assess anxiety-like phenotypes and validate the pharmacological effects of neuroactive compounds. This test has been recently adapted for adult zebrafish but has not yet been characterized and pharma
Publikováno v:
Birth Defects Research Part C: Embryo Today: Reviews. 93:115-133
Technological innovation has helped the zebrafish embryo gain ground as a disease model and an assay system for drug screening. Here, we review the use of zebrafish embryos and early larvae in applied biomedical research, using selected cases. We loo
Publikováno v:
Behavioural Brain Research, 214(2), 332-342
The current study provides a detailed description of the pattern of exploratory behaviors encountered in adult zebrafish when exposed to a novel/unfamiliar environment using the light/dark box and open field tests. We also document the impact of an a
Autor:
Michael J. Meaney, Danielle L. Champagne, Harm J. Krugers, Marian Joëls, Felisa N. van Hasselt, Rosemary C. Bagot
Publikováno v:
Neurobiology of Learning and Memory, 92(3), 292-300. Academic Press Inc.
Maternal care in the rat influences hippocampal development, synaptic plasticity and cognition. Previous studies, however, have examined animals under minimally stressful conditions. Here we tested the hypothesis that maternal care influences hippoca