Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Danielle L. Brown"'
Publikováno v:
Toxicology Letters. 344:34-45
ASP7962 is a small molecule inhibitor for the nerve growth factor (NGF) receptor, tropomyosin-related kinase A (TrkA). NGF contributes to the survival of sensory and sympathetic neurons through TrkA receptor activation. Gross, microscopic, and quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8d5b8c41b13e366568f16b7fcbc411
https://doi.org/10.1016/j.toxlet.2021.02.018
https://doi.org/10.1016/j.toxlet.2021.02.018
Autor:
Daniel G. Rudmann, Danielle L. Brown, Robert Klopfleisch, Thomas Westerling-Bui, Aleksandra Zuraw, Michael Staup, Famke Aeffner
Publikováno v:
Toxicologic Pathology. 49:773-783
Digital tissue image analysis is a computational method for analyzing whole-slide images and extracting large, complex, and quantitative data sets. However, as with any analysis method, the quality of generated results is dependent on a well-designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8785dd00fb0a0672afbfb12eb1b8556
https://doi.org/10.1177/0192623320980310
https://doi.org/10.1177/0192623320980310
Publikováno v:
Toxicologic Pathology. 48:37-48
Qualitative histopathology has been the gold standard for evaluation of morphological tissue changes in all organ systems, including the peripheral nervous system. However, the human eye is not sensitive enough to detect small changes in quantity or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fb7d29361b0d3ab4f92d04a3b8e0b1
https://doi.org/10.1177/0192623319854746
https://doi.org/10.1177/0192623319854746
Autor:
Ana Töpf, Helen R Griffin, Elise Glen, Rachel Soemedi, Danielle L Brown, Darroch Hall, Thahira J Rahman, Jyrki J Eloranta, Christoph Jüngst, A Graham Stuart, John O'Sullivan, Bernard D Keavney, Judith A Goodship
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e95453 (2014)
OBJECTIVE:Rare variants in certain transcription factors involved in cardiac development cause Mendelian forms of congenital heart disease. The purpose of this study was to systematically assess the frequency of rare transcription factor variants in
Externí odkaz:
https://doaj.org/article/386c4939204b4a59bd3dd55c241a712e
Autor:
Suramya Waidyanatha, Keith R. Shockley, Robert C. Sills, Jesse D. Cushman, Mark F. Cesta, Sheba R Churchill, Michael Staup, Peter B. Little, Danielle L. Brown, Veronica G. Robinson, Mamta Behl, Crystal L. Johnson, David M Kurtz, G. Allan Johnson, Robert J. Anderson, Danica M.K. Andrews
Publikováno v:
Toxicol Pathol
It is well established that hexachlorophene, which is used as an antibacterial agent, causes intramyelinic edema in humans and animal models. The hexachlorophene myelinopathy model, in which male Sprague-Dawley rats received 25 to 30 mg/kg hexachloro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4bcaf64132171fad9ca26d7aea5a7e
https://pubmed.ncbi.nlm.nih.gov/33334257
https://pubmed.ncbi.nlm.nih.gov/33334257
Autor:
Rogely W. Boyce, Kathrin Locher, Scott Taylor, Ian Pyrah, Nacera Mellal, Danielle L. Brown, Michael S. Ominsky, Melanie Felx
Publikováno v:
Bone Reports, Vol 8, Iss, Pp 90-94 (2018)
Bone Reports
Bone Reports
Sclerostin antibody (Scl-Ab) stimulates bone formation, which with long-term treatment, attenuates over time. The cellular and molecular mechanisms responsible for the attenuation of bone formation are not well understood, but in aged ovariectomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c283365fc79c0da6146f00c605168be0
https://doi.org/10.1016/j.bonr.2018.03.001
https://doi.org/10.1016/j.bonr.2018.03.001
Autor:
Sasmita Mishra, Vanessa L. Schumacher, Jean-Rene Galarneau, Chandrassegar Saravanan, Marielle Odin, Danielle L. Brown, Robert W. Dunstan
Publikováno v:
Toxicologic Pathology. 45:983-1003
Quantitative image analysis (IA) is a rapidly evolving area of digital pathology. Although not a new concept, the quantification of histological features on photomicrographs used to be cumbersome, resource-intensive, and limited to specialists and sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec158f041ff98121beb3c535bcf401b5
https://doi.org/10.1177/0192623317737468
https://doi.org/10.1177/0192623317737468
Autor:
Danielle L. Brown
Publikováno v:
Journal of Toxicologic Pathology
Although the human eye is excellent for pattern recognition, it often lacks the sensitivity to detect subtle changes in particle density. Because of this, quantitative evaluation may be required in some studies. A common type of quantitative assessme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516dbb8f5920c9fe17d33a1cd24cb0e4
https://doi.org/10.1293/tox.2017-0013
https://doi.org/10.1293/tox.2017-0013
Autor:
Manu M. Sebastian, Tobias Sing, Bhupinder Bawa, Anantharaman Muthuswamy, Tom Forest, Danielle L. Brown, Daniel G. Rudmann, Olulanu H Aina, Brian Knight, Oliver C. Turner, Wanda High, Lauren E. Himmel, Famke Aeffner, Elijah F. Edmondson, Dinesh S. Bangari, Chandrassegar Saravanan, Brieuc Cossic
Publikováno v:
Toxicologic pathology. 48(2)
Toxicologic pathology is transitioning from analog to digital methods. This transition seems inevitable due to a host of ongoing social and medical technological forces. Of these, artificial intelligence (AI) and in particular machine learning (ML) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab406066e2273b8f44ac25804efbd3db
https://pubmed.ncbi.nlm.nih.gov/31645203
https://pubmed.ncbi.nlm.nih.gov/31645203
Autor:
Rogely W. Boyce, Sabina Buntich, J. Ignacio Aguirre, Yudong D. He, Efrain Pacheco, Cynthia A. Afshari, Scott Taylor, Ian Pyrah, Michael S. Ominsky, Danielle L. Brown, Paul Nioi, Thomas J. Wronski, Rong Hu
Publikováno v:
Bone. 84:148-159
Inhibition of sclerostin with sclerostin antibody (Scl-Ab) has been shown to stimulate bone formation, decrease bone resorption, and increase bone mass in both animals and humans. To obtain insight into the temporal cellular and transcriptional chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026f46b0638d289639d1c4a135ebc5dd
https://doi.org/10.1016/j.bone.2015.12.013
https://doi.org/10.1016/j.bone.2015.12.013