Výsledky vyhledávání - "Danielle L Swaney"

Akademický článek

Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms

Publikováno v: eLife, Vol 12 (2023)

Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood. We used global phosphoproteomics and kinase activity profiling to map conserved signal

Externí odkaz: https://doaj.org/article/05fc37cffa674796bf7877b4353fc32a

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Akademický článek

The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae.

Autor: Emma B Alme, Erica Stevenson, Nevan J Krogan, Danielle L Swaney, David P Toczyski

Publikováno v: PLoS Genetics, Vol 16, Iss 6, p e1008840 (2020)

The S. cerevisiae ISR1 gene encodes a putative kinase with no ascribed function. Here, we show that Isr1 acts as a negative regulator of the highly-conserved hexosamine biosynthesis pathway (HBP), which converts glucose into uridine diphosphate N-ace

Externí odkaz: https://doaj.org/article/5877c900521f403b85a3ded6c4024ac8

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Akademický článek

Dynamic post-translational modification profiling of Mycobacterium tuberculosis-infected primary macrophages

Autor: Jonathan M Budzik, Danielle L Swaney, David Jimenez-Morales, Jeffrey R Johnson, Nicholas E Garelis, Teresa Repasy, Allison W Roberts, Lauren M Popov, Trevor J Parry, Dexter Pratt, Trey Ideker, Nevan J Krogan, Jeffery S Cox

Publikováno v: eLife, Vol 9 (2020)

Macrophages are highly plastic cells with critical roles in immunity, cancer, and tissue homeostasis, but how these distinct cellular fates are triggered by environmental cues is poorly understood. To uncover how primary murine macrophages respond to

Externí odkaz: https://doaj.org/article/cde5e721c9b14b919299582e8f3eddb4

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Akademický článek

MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features

Autor: Charlotte D. Eaton, Lauro Avalos, S. John Liu, Zhenhong Chen, Naomi Zakimi, Tim Casey-Clyde, Paola Bisignano, Calixto-Hope G. Lucas, Erica Stevenson, Abrar Choudhury, Harish N. Vasudevan, Stephen T. Magill, Jacob S. Young, Nevan J. Krogan, Javier E. Villanueva-Meyer, Danielle L. Swaney, David R. Raleigh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Meningiomas are associated with inactivation of NF2/Merlin, but approximately one-third of meningiomas with favorable clinical outcomes retain Merlin expression. Biochemical mechanisms underlying Merlin-intact meningioma growth are incomplet

Externí odkaz: https://doaj.org/article/09cad89a882942b286e00cb8af45c58a

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Akademický článek

The Chlamydia trachomatis Inc Tri1 interacts with TRAF7 to displace native TRAF7 interacting partners

Autor: Clara M. Herrera, Eleanor McMahon, Danielle L. Swaney, Jessica Sherry, Khavong Pha, Kathleen Adams-Boone, Jeffrey R. Johnson, Nevan J. Krogan, Meredith Stevers, David Solomon, Cherilyn Elwell, Joanne Engel

Publikováno v: Microbiology Spectrum, Vol 12, Iss 7 (2024)

ABSTRACT Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections in the USA and of preventable blindness worldwide. This obligate intracellular pathogen replicates within a membrane-bound inclusion, but how it acquires

Externí odkaz: https://doaj.org/article/316a7c5ab6484e04be8480b805d8a985

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Akademický článek

Epigenetic reprogramming shapes the cellular landscape of schwannoma

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Mechanisms specifying cancer cell states and response to therapy are incompletely understood. Here we show epigenetic reprogramming shapes the cellular landscape of schwannomas, the most common tumors of the peripheral nervous system. We fin

Externí odkaz: https://doaj.org/article/6c3cb10a1a664ce0a55f363c96e7591d

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Akademický článek

CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells

Publikováno v: mBio, Vol 15, Iss 4 (2024)

ABSTRACTDuring HIV infection of CD4+ T cells, ubiquitin pathways are essential to viral replication and host innate immune response; however, the role of specific E3 ubiquitin ligases is not well understood. Proteomics analyses identified 116 single-

Externí odkaz: https://doaj.org/article/a68bf9f80cd74600b676bdd895184026

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Akademický článek

Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy

Autor: Gregory J. Krause, Philipp Kirchner, Barbara Stiller, Kateryna Morozova, Antonio Diaz, Kuei-Ho Chen, Nevan J. Krogan, Esperanza Agullo-Pascual, Cristina C. Clement, Kristen Lindenau, Danielle L. Swaney, Shilpa Dilipkumar, Jose Javier Bravo-Cordero, Laura Santambrogio, Ana Maria Cuervo

Publikováno v: Cell Reports, Vol 42, Iss 12, Pp 113529- (2023)

Summary: Chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI) are pathways for selective degradation of cytosolic proteins in lysosomes and late endosomes, respectively. These autophagic processes share as a first step the recognitio

Externí odkaz: https://doaj.org/article/d2a335d99ba9457284f584165e90233a

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