Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Danielle L Michell"'
5‐Fluorouracil treatment represses pseudouridine‐containing miRNA export into extracellular vesicles
Autor:
Shimian Qu, Hannah M. Nelson, Xiao Liu, Yu Wang, Elizabeth M. Semler, Danielle L. Michell, Clark Massick, Jeffrey L. Franklin, John Karijolich, Alissa M. Weaver, Robert J. Coffey, Qi Liu, Kasey C. Vickers, James G. Patton
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 9, Pp n/a-n/a (2024)
Abstract 5‐Fluorouracil (5‐FU) has been used for chemotherapy for colorectal and other cancers for over 50 years. The prevailing view of its mechanism of action is inhibition of thymidine synthase leading to defects in DNA replication and repair.
Externí odkaz:
https://doaj.org/article/6e5702c671f04d8e9a2013298d18c044
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Justin H. Lo, Ashley B. Cavnar, Lauren M. Babb, Nora Francini, Eva F. Gbur, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics
Externí odkaz:
https://doaj.org/article/a8ad79f8d57c45aeac75fe1a848bd947
Autor:
Mark Castleberry, Chase A. Raby, Anca Ifrim, Yasuhiro Shibata, Sachi Matsushita, Shinya Ugawa, Yutaka Miura, Atsushi Hori, Takashi Miida, MacRae F. Linton, Danielle L. Michell, Maki Tsujita, Kasey C. Vickers
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 2, Pp 100328- (2023)
HDL are dynamic transporters of diverse molecular cargo and play critical roles in lipid metabolism and inflammation. We have previously reported that HDL transport both host and nonhost small RNAs (sRNA) based on quantitative PCR and sRNA sequencing
Externí odkaz:
https://doaj.org/article/cb43c8cf5bf44960a92d7fff11b1433f
Autor:
Danielle L. Michell, Waled A. Shihata, Karen L. Andrews, Nurul Aisha Zainal Abidin, Ann-Maree Jefferis, Amanda K. Sampson, Natalie G. Lumsden, Olivier Huet, Marie-Odile Parat, Garry L. Jennings, Robert G. Parton, Kevin J. Woollard, David M. Kaye, Jaye P. F. Chin-Dusting, Andrew J. Murphy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The aetiology and progression of hypertension involves various endogenous systems, such as the renin angiotensin system, the sympathetic nervous system, and endothelial dysfunction. Recent data suggest that vascular inflammation may also pla
Externí odkaz:
https://doaj.org/article/89d56ef6af8740c7a60458ad31b61cc1
Autor:
Dragana Dragoljevic, Camilla Bertuzzo Veiga, Danielle L. Michell, Waled A. Shihata, Annas Al-Sharea, Geoffrey A. Head, Andrew J. Murphy, Michael J. Kraakman, Man K.S. Lee
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss , Pp 111668- (2021)
Metabolic Syndrome (MetS) is a complex and multifactorial condition often characterised by obesity, hypertension, hyperlipidaemia, insulin resistance, glucose intolerance and fasting hyperglycaemia. Collectively, MetS can increase the risk of atheros
Externí odkaz:
https://doaj.org/article/8a1768f2b3d54c13b0d3b1ce9900b53c
Autor:
Annas Al-Sharea, Man K. S. Lee, Alexandra Whillas, Danielle L. Michell, Waled A. Shihata, Alyce J. Nicholls, Olivia D. Cooney, Michael J. Kraakman, Camilla Bertuzzo Veiga, Ann-Maree Jefferis, Kristy Jackson, Prabhakara R. Nagareddy, Gavin Lambert, Connie H. Y. Wong, Karen L. Andrews, Geoff A. Head, Jaye Chin-Dusting, Andrew J. Murphy
Publikováno v:
Haematologica, Vol 104, Iss 3 (2019)
Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic ne
Externí odkaz:
https://doaj.org/article/4e2a37be40d14ab48b844e3e3f467be4
Autor:
Ryan M. Allen, Shilin Zhao, Marisol A. Ramirez Solano, Wanying Zhu, Danielle L. Michell, Yuhuan Wang, Yu Shyr, Praveen Sethupathy, MacRae F. Linton, Gregory A. Graf, Quanhu Sheng, Kasey C. Vickers
Publikováno v:
Journal of Extracellular Vesicles, Vol 7, Iss 1 (2018)
To comprehensively study extracellular small RNAs (sRNA) by sequencing (sRNA-seq), we developed a novel pipeline to overcome current limitations in analysis entitled, “Tools for Integrative Genome analysis of Extracellular sRNAs (TIGER)”. To demo
Externí odkaz:
https://doaj.org/article/7a35d40986b3418c892ee4a7ab71ad1e
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Ashley B. Cavnar, Justin H. Lo, Lauren M. Babb, Nora Francini, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
bioRxiv
The high potential for therapeutic application of siRNAs to silence traditionally undruggable oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, siRNAs were optimized forin situbinding to albumin through C1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed437d3b4e1884a99c1762f14a4e284b
https://doi.org/10.1101/2023.02.14.528574
https://doi.org/10.1101/2023.02.14.528574
Autor:
Mark Castleberry, Chase Raby, Ryan Allen, Danielle L Michell, Anca M Ifrim, MacRae F Linton, Kasey C Vickers
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
HDL are a class of dynamic particles that play critical roles in lipid metabolism, inflammation, and cell signaling. HDL are small, highly-mobile carriers of diverse molecular cargo, that include many types of host and non-host small RNAs (sRNA), as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::770bbcba14331f26a29aa45d346b98cd
https://doi.org/10.1161/atvb.42.suppl_1.514
https://doi.org/10.1161/atvb.42.suppl_1.514
Autor:
Elizabeth M Semler, Danielle L Michell, Ryan M Allen, Marisol Ramirez-Solano, MacRae F Linton, Quanhu Sheng, Kasey C Vickers
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Atherosclerotic cardiovascular disease (ASCVD) is a complex disease of uncontrolled hypercholesterolemia and inflammation. High-density lipoproteins (HDL) have been shown to suppress atherogenesis through multiple processes; however, many of HDL’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f46c86822afc5a3d55e1f81ea6dd3a7
https://doi.org/10.1161/atvb.42.suppl_1.449
https://doi.org/10.1161/atvb.42.suppl_1.449