Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Danielle L, Leiske"'
Autor:
Danielle L. Leiske, Eric M. Furst, Christopher J. Roberts, William J. Galush, Mahlet A. Woldeyes, Lilian Lam Josephson
Publikováno v:
Molecular Pharmaceutics. 15:4745-4755
Solution viscosities (η) and protein-protein interactions (PPI) of three monoclonal antibodies (mAb-A, mAb-B, mAb-C), two bispecific antibodies (BsAb-A/B, BsAb-A/C), and two 1:1 binary mixtures (mAb-A + mAb-B and mAb-A + mAb-C) were measured. mAb-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee7ff0e376b0822ef608a480df1ccc1
https://doi.org/10.1021/acs.molpharmaceut.8b00706
https://doi.org/10.1021/acs.molpharmaceut.8b00706
Autor:
Amy Hilderbrand, Daniel Bregante, Nisana Andersen, Wayman Chan, Michelle Z. Dion, Y. John Wang, Danielle L. Leiske, Cleo M. Salisbury
Publikováno v:
Journal of Pharmaceutical Sciences. 107:550-558
Protein oxidation is a major pathway for degradation of biologic drug products. Past literature reports have suggested that 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH), a free radical generator that produces alkoxyl and alkyl peroxyl radical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40ad9e0a6eacbac1b1f1ec31f3901d4
https://doi.org/10.1016/j.xphs.2017.09.022
https://doi.org/10.1016/j.xphs.2017.09.022
Publikováno v:
Langmuir. 32:9930-9937
Proteins are surface-active molecules that have a propensity to adsorb to hydrophobic interfaces, such as the air-liquid interface. Surface flow can increase aggregation of adsorbed proteins, which may be an undesirable consequence depending on the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4337d45e1a58395701c367ed19a738b
https://doi.org/10.1021/acs.langmuir.6b02267
https://doi.org/10.1021/acs.langmuir.6b02267
Autor:
Cleo M. Salisbury, Danielle L. Leiske, Vikas K. Sharma, Christina L. Zuch de Zafra, Michelle Z. Dion
Publikováno v:
Pharmaceutical Research. 35
Biotherapeutics can be susceptible to oxidation during manufacturing and storage. Free L-methionine is known to protect methionine residues in proteins from oxidation. Similarly, free tryptophan and other indole derivatives have been shown to protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c7c8944fd3fb4a9ed5fab389dd950d
https://doi.org/10.1007/s11095-018-2467-5
https://doi.org/10.1007/s11095-018-2467-5
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 34(2)
Monoclonal antibodies (mAbs) are proteins that uniquely identify targets within the body, making them well-suited for therapeutic applications. However, these amphiphilic molecules readily adsorb onto air-solution interfaces where they tend to aggreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07179a35eb8bb0343ab89708fc8d75a
https://pubmed.ncbi.nlm.nih.gov/29251942
https://pubmed.ncbi.nlm.nih.gov/29251942
Autor:
Danielle, Leiske, Danielle L, Leiske, Christopher, Leiske, Christopher I, Leiske, Daniel, Leiske, Daniel R, Leiske, Michael, Toney, Michael F, Toney, Michelle, Senchyna, Howard, Ketelson, Howard A, Ketelson, David, Meadows, David L, Meadows, Gerald G, Fuller
Publikováno v:
Biophysical journal. 113(11)
Meibomian lipids are the primary component of the lipid layer of the tear film. Composed primarily of a mixture of lipids, meibum exhibits a range of melt temperatures. Compositional changes that occur with disease may alter the temperature at which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef22fc76c9c41ea75e789f137899df41
https://pubmed.ncbi.nlm.nih.gov/22339874
https://pubmed.ncbi.nlm.nih.gov/22339874
Publikováno v:
Journal of pharmaceutical sciences. 106(12)
N-Acetyl-tryptophan (NAT) is used as a stabilizer for preparations of human serum albumin and has more recently been demonstrated to provide oxidative protection for labile Trp residues in monoclonal antibodies. As a component in the formulations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59fdada278cda098c625dddf85232ec
https://pubmed.ncbi.nlm.nih.gov/28844684
https://pubmed.ncbi.nlm.nih.gov/28844684
Publikováno v:
Langmuir. 29:1948-1955
3-Hydroxybutyric acid (also referred to as β-hydroxybutyric acid or BHB), a small molecule metabolite whose concentration is elevated in type I diabetes and diabetic coma, was found to modulate the properties of 1,2-dipalmitoyl-sn-glycero-3-phosphoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0184df5c0487650d9276ce1d2412008d
https://doi.org/10.1021/la304712f
https://doi.org/10.1021/la304712f
Publikováno v:
Analytical biochemistry. 487
A label-free method for DNA sequencing based on the principle of the Millikan oil drop experiment was developed. This sequencing-by-synthesis approach sensed increases in bead charge as nucleotides were added by a polymerase to DNA templates attached
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61770e6ba20c141bcaaa3b8055c4bc46
https://pubmed.ncbi.nlm.nih.gov/26151683
https://pubmed.ncbi.nlm.nih.gov/26151683
Publikováno v:
Analytical biochemistry. 448
The ability to monitor the progress of single molecule enzyme reactions is often limited by the need to use fluorogenic substrates. A method based on the principle of the Millikan Oil Drop Experiment was developed to monitor the change in charge of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c384cf573d2158019d1b5fcd62193820
https://pubmed.ncbi.nlm.nih.gov/24291542
https://pubmed.ncbi.nlm.nih.gov/24291542