Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Danielle Kellar"'
Autor:
Laura-Isobel McCall, Amale El Aroussi, Jun Yong Choi, Debora F Vieira, Geraldine De Muylder, Jonathan B Johnston, Steven Chen, Danielle Kellar, Jair L Siqueira-Neto, William R Roush, Larissa M Podust, James H McKerrow
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003588 (2015)
Leishmania protozoan parasites (Trypanosomatidae family) are the causative agents of cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are associated with significant morbidity and mortality, there are few adequate t
Externí odkaz:
https://doaj.org/article/58924484fcc34757ab91165c0f1e5fe2
Autor:
Sean Ekins, Jair Lage de Siqueira-Neto, Laura-Isobel McCall, Malabika Sarker, Maneesh Yadav, Elizabeth L Ponder, E Adam Kallel, Danielle Kellar, Steven Chen, Michelle Arkin, Barry A Bunin, James H McKerrow, Carolyn Talcott
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003878 (2015)
BACKGROUND:Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity. METHODOLOGY/PRINCIPAL
Externí odkaz:
https://doaj.org/article/b9e8a9fd005b4febbb1b946f9673640a
Autor:
James H. McKerrow, R. Jeffrey Neitz, Jiri Gut, Adam R. Renslo, Michelle R. Arkin, Danielle Kellar, Frantisek Supek, Valentina Molteni, Stephanie A. Robertson, Alejandra Gallardo-Godoy, Steven Chen, Jair L. Siqueira-Neto, Vince Yeh, Richard Glynne, Steven L. Roach, Clifford Bryant, Arnab K. Chatterjee
Publikováno v:
SLAS Discovery. 20:101-111
Chagas disease affects 8 million people worldwide and remains a main cause of death due to heart failure in Latin America. The number of cases in the United States is now estimated to be 300,000, but there are currently no Food and Drug Administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe87b7f6b3b7366cba4100e54ca8f43
https://doi.org/10.1177/1087057114553103
https://doi.org/10.1177/1087057114553103
Autor:
Charles C. Kim, Eric J. Huang, Alyssa Baccarella, Mary F. Fontana, Danielle Kellar, De'Broski R. Herbert, Sarah D. Rosenberg, Paul Terinate, Taylor K. Oniskey
Publikováno v:
Parasite immunology, vol 37, iss 9
Summary Activation of macrophages is a key step in the initiation of immune responses, but the transcriptional mechanisms governing macrophage activation during infection are not fully understood. It was recently shown that the AP-1 family transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54fb5c93d06ce685e5c5fcb9a611e15
https://escholarship.org/uc/item/0hh663nx
https://escholarship.org/uc/item/0hh663nx
Autor:
James H. McKerrow, Steven Chen, Danielle Kellar, Jair L. Siqueira-Neto, Michelle R. Arkin, Laura-Isobel McCall, Maneesh K. Yadav, E. Adam Kallel, Carolyn L. Talcott, Barry A. Bunin, Elizabeth L. Ponder, Sean Ekins, Malabika Sarker
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003878 (2015)
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003878 (2015)
Background Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity. Methodology/Principal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6330f78da8f6ba9d1a31abef256bcba
http://europepmc.org/articles/PMC4482694
http://europepmc.org/articles/PMC4482694
Autor:
Jair L. Siqueira-Neto, Debora F. Vieira, Jiri Gut, Jun Yong Choi, William R. Roush, Claudia M. Calvet, Larissa M. Podust, Michael D. Cameron, James H. McKerrow, Jonathan B. Johnston, Danielle Kellar
Publikováno v:
Journal of medicinal chemistry, vol 57, iss 23
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Chagas disease is a chronic infection in humans caused by Trypanosoma cruzi and manifested in progressive cardiomyopathy and/or gastrointestinal dysfunction. Limited therapeutic options to prevent and treat Chagas disease put 8 million people infecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5dadcf79f4b9fe8bab74292889edfa
https://escholarship.org/uc/item/3j62x4nt
https://escholarship.org/uc/item/3j62x4nt
Autor:
Thiago Belarmino de Souza, Conor R. Caffrey, Silvane M. F. Murta, Policarpo Ademar Sales Junior, James H. McKerrow, Danielle Kellar, Ricardo José Alves, Filipe Silva Villela, Glaécia Aparecida do Nascimento Pereira, Alvaro J. Romanha, Debalina Ray, Renata Barbosa de Oliveira, Brian M. Suzuki, Rafaela Salgado Ferreira, Nayara Cristina Fonseca, Jair L. Siqueira-Neto, Luana Faria da Cruz
Publikováno v:
Antimicrobial agents and chemotherapy. 59(5)
The pressing need for better drugs against Chagas disease, African sleeping sickness, and schistosomiasis motivates the search for inhibitors of cruzain, rhodesain, and Schistosoma mansoni CB1 (SmCB1), the major cysteine proteases from Trypanosoma cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb47763e32a3e5f26097d7b63ccf91d1
https://pubmed.ncbi.nlm.nih.gov/25712353
https://pubmed.ncbi.nlm.nih.gov/25712353
Autor:
Li Lin, Jair L. Siqueira-Neto, Debora F. Vieira, Danielle Kellar, Jiri Gut, Jonathan B. Johnston, Michael D. Cameron, James H. McKerrow, Susan Khan, William R. Roush, Larissa M. Podust, Claudia M. Calvet, Jun Yong Choi
Publikováno v:
Journal of Medicinal Chemistry
Journal of medicinal chemistry, vol 57, iss 16
Journal of medicinal chemistry, vol 57, iss 16
CYP51 is a P450 enzyme involved in the biosynthesis of the sterol components of eukaryotic cell membranes. CYP51 inhibitors have been developed to treat infections caused by fungi, and more recently the protozoan parasite Trypanosoma cruzi, the causa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1890f7e29378b56ff89ddb55af8db318
https://pubmed.ncbi.nlm.nih.gov/25101801
https://pubmed.ncbi.nlm.nih.gov/25101801
Autor:
Sivaraman Dandapani, Marcel Kaiser, Jeremy R. Duvall, Andrew R. Germain, Juan C. Engel, José Carlos Rodríguez Pérez, Stuart L. Schreiber, Sebastian T. Le Quement, Danielle Kellar, Benito Munoz, Giovanni Muncipinto, James H. McKerrow, Michael Foley, Jiri Gut, Jean-Charles Marie, Michelle Palmer, Leigh C. Carmody, Ivan T. Jewett, Jair L. Siqueira-Neto, Ana Rodriguez
A phenotypic high-throughput screen using ∼100,000 compounds prepared using Diversity-Oriented Synthesis yielded stereoisomeric compounds with nanomolar growth-inhibition activity against the parasite Trypanosoma cruzi, the etiological agent of Cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566271c6a656525fb1715e6147271240
https://europepmc.org/articles/PMC4027639/
https://europepmc.org/articles/PMC4027639/
Autor:
Steven W. Chen, Vince Yeh, Frantisek Supek, James H. McKerrow, Michelle R. Arkin, Arnab Chatterjee, Clifford Bryant, R. Jeffrey Neitz, Shilpi Khare, Alejandra Gallardo-Godoy, Jiri Gut, Steven L. Roach, Stephanie A. Robertson, Danielle Kellar, Richard Glynne, Valentina Molteni, Monique Stinson, Jair L. Siqueira-Neto, Adam R. Renslo
Publikováno v:
SLAS Discovery. 20:927
R. Jeffrey Neitz, Steven Chen, Frantisek Supek, Vince Yeh, Danielle Kellar, Jiri Gut, Clifford Bryant, Alejandra Gallardo-Godoy, Valentina Molteni, Steven L. Roach, Arnab K. Chatterjee, Stephanie Robertson, Adam R. Renslo, Michelle Arkin, Richard Gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::851ca952971d740d85d2403142ec43ee
https://doi.org/10.1177/1087057115593092
https://doi.org/10.1177/1087057115593092