Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Danielle J LaValley"'
Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro.
Autor:
René F M van Oers, Elisabeth G Rens, Danielle J LaValley, Cynthia A Reinhart-King, Roeland M H Merks
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 8, p e1003774 (2014)
In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extracellular matrix, endothelial cells can form blood vessel-like structu
Externí odkaz:
https://doaj.org/article/a3b0a727f09e482c8661e4f06e080b92
Autor:
Joseph P. Miller, Brandon H. Borde, Francois Bordeleau, Matthew R. Zanotelli, Danielle J. LaValley, Dylan J. Parker, Lawrence J. Bonassar, Susan C. Pannullo, Cynthia A. Reinhart-King
Publikováno v:
APL Bioengineering, Vol 2, Iss 3, Pp 031901-031901-11 (2018)
Cells receive mechanical cues from their extracellular matrix (ECM), which direct migration, differentiation, apoptosis, and in some cases, the transition to a cancerous phenotype. As a result, there has been significant research to develop methods t
Externí odkaz:
https://doaj.org/article/223ef4ec142d441abf2b1ed6d41a7e83
Publikováno v:
Biotechnology progressREFERENCES. 37(2)
Drug development is often hindered by the failure of preclinical models to accurately assess and predict the efficacy and safety of drug candidates. Body-on-a-chip (BOC) microfluidic devices, a subset of microphysiological systems (MPS), are being cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a043979ecd2768a7a04a478e7fc60a3
https://pubmed.ncbi.nlm.nih.gov/33274840
https://pubmed.ncbi.nlm.nih.gov/33274840
Autor:
Jonathan T. Butcher, Francois Bordeleau, Danielle J. LaValley, Yashira L Negrón Abril, Robert S. Weiss, Sahana Somasegar, Nuria Mencia-Trinchant, John Huynh, Joseph P. Califano, Duane C. Hassane, Michael Mazzola, Matthew R. Zanotelli, Cynthia A. Reinhart-King, Emmanuel Macklin Lollis, Christine R Montague, Brooke N. Mason, Lawrence J. Bonassar
Publikováno v:
Proceedings of the National Academy of Sciences. 114:492-497
Tumor microvasculature tends to be malformed, more permeable, and more tortuous than vessels in healthy tissue, effects that have been largely attributed to up-regulated VEGF expression. However, tumor tissue tends to stiffen during solid tumor progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a787ba8c123a3e359cd387502ac6da
https://doi.org/10.1073/pnas.1613855114
https://doi.org/10.1073/pnas.1613855114
Autor:
Matthew R. Zanotelli, Cynthia A. Reinhart-King, Brandon Borde, Lawrence J. Bonassar, Danielle J. LaValley, Joseph Miller, Francois Bordeleau, Susan C. Pannullo, Dylan J. Parker
Publikováno v:
APL Bioengineering
APL Bioengineering, Vol 2, Iss 3, Pp 031901-031901-11 (2018)
APL Bioengineering, Vol 2, Iss 3, Pp 031901-031901-11 (2018)
Cells receive mechanical cues from their extracellular matrix (ECM), which direct migration, differentiation, apoptosis, and in some cases, the transition to a cancerous phenotype. As a result, there has been significant research to develop methods t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711515b72cd8dba2e177eb0d3c9da78e
http://europepmc.org/articles/PMC6324208
http://europepmc.org/articles/PMC6324208
Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells
Autor:
Samantha C. Schwager, Matthew R. Zanotelli, Danielle J. LaValley, Francois Bordeleau, Cynthia A. Reinhart-King, Wenjun Wang
Publikováno v:
Convergent science physical oncology. 3
Vascular endothelial growth factor (VEGF) can mediate endothelial cell migration, proliferation, and angiogenesis. During cancer progression, VEGF production is often increased to stimulate the growth of new blood vessels to supply growing tumors wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1eefc19ba3e857cf389425847b432d
https://pubmed.ncbi.nlm.nih.gov/29531793
https://pubmed.ncbi.nlm.nih.gov/29531793
Autor:
Joseph P. Califano, Sandra J. Shin, Brooke N. Mason, Robert S. Weiss, Francois Bordeleau, Yashira L Negrón Abril, Cynthia A. Reinhart-King, Danielle J. LaValley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(27)
Alternative splicing of proteins gives rise to different isoforms that play a crucial role in regulating several cellular processes. Notably, splicing profiles are altered in several cancer types, and these profiles are believed to be involved in dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac71c014a73d3f5d691f96b4e4c4d07
https://pubmed.ncbi.nlm.nih.gov/26106154
https://pubmed.ncbi.nlm.nih.gov/26106154
Autor:
Cynthia A. Reinhart-King, Elisabeth G. Rens, Roeland M. H. Merks, Danielle J. LaValley, René F.M. van Oers
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 10, Iss 8, p e1003774 (2014)
PLoS Computational Biology, 10(08)
PLoS Computational Biology, Vol 10, Iss 8, p e1003774 (2014)
PLoS Computational Biology, 10(08)
In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extracellular matrix, endothelial cells can form blood vessel-like structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000f8dd953057369592e5d19a80a395e
https://doi.org/10.1371/journal.pcbi.1003774
https://doi.org/10.1371/journal.pcbi.1003774
Publikováno v:
Advances in Regenerative Biology; Vol 1 (2014)
Angiogenesis, the process where new blood vessels form from existing vasculature, is essential for the successful integration of most tissue-engineered constructs and is dysregulated in many diseases, including cancer. To be functional, the newly for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060ae8e053451930598c3709f62c8e83
https://doi.org/10.3402/arb.v1.25247
https://doi.org/10.3402/arb.v1.25247