Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases.

Autor: Marieke A Vollebergh, Christiaan Klijn, Philip C Schouten, Jelle Wesseling, Danielle Israeli, Bauke Ylstra, Lodewyk F A Wessels, Jos Jonkers, Sabine C Linn

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e103177 (2014)

Lymph-node metastasis (LNM) predict high recurrence rates in breast cancer patients. Systemic treatment aims to eliminate (micro)metastatic cells. However decisions regarding systemic treatment depend largely on clinical and molecular characteristics

Externí odkaz: https://doaj.org/article/627f62365ed44631903e3bb2e86a2309

Chromosome 20p11 gains are associated with liver-specific metastasis in patients with colorectal cancer

Autor: Cornelis J. A. Punt, Iris D. Nagtegaal, Steven Teerenstra, Miriam Koopman, Bauke Ylstra, M. Elisa Vink-Börger, Leonie J. M. Mekenkamp, Josien C. Haan, Danielle Israeli, Gerrit A. Meijer

Publikováno v: Mekenkamp, L J M, Haan, J C, Koopman, M, Vink-Borger, M E, Israeli, D, Teerenstra, S, Ylstra, B, Meijer, G A, Punt, C J A & Nagtegaal, I D 2013, ' Chromosome 20p11 gains are associated with liver-specific metastasis in patients with colorectal cancer ', Gut, vol. 62, no. 1, pp. 94-101 . https://doi.org/10.1136/gutjnl-2011-301587
Gut, 62, 94-101
Gut, 62(1), 94-101. BMJ Publishing Group
Gut, 62, 1, pp. 94-101

Contains fulltext : 118135pub.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Metastatic colorectal cancer (CRC) cells have a selective preference for certain target organs that cannot be explained by circulatory patterns alone. This study ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fe559da49687a98990a8150eacb649
https://doi.org/10.1136/gutjnl-2011-301587

Genomic landscape of metastatic colorectal cancer

Autor: Bauke Ylstra, Mariette Labots, Christian Rausch, Nicole C.T. van Grieken, Xueping Qu, Gerrit A. Meijer, Hendrik F. van Essen, Omar Kabbarah, Cornelis J. A. Punt, Quirinus J. M. Voorham, Henk M.W. Verheul, Iris D. Nagtegaal, Jolien Tol, Mark A. van de Wiel, Leonie J. M. Mekenkamp, Linda J.W. Bosch, Miriam Koopman, Danielle Israeli, Josien C. Haan

Publikováno v: Nature Communications
Nature Communications, 5, 5457
Nature communications, 5. Nature Publishing Group
Nature Communications, 5, pp. 5457
Haan, J C, Labots, M, Rausch, C, Koopman, M, de Nooy-van Tol, J, Mekenkamp, L J M, van de Wiel, M A, Israeli, D, van Essen, H F, van Grieken, N C T, Voorham, Q J M, Bosch, L J W, Qu, X, Kabbarah, O, Verheul, H M W, Nagtegaal, I D, Punt, C J A, Ylstra, B & Meijer, G A 2014, ' Genomic landscape of metastatic colorectal cancer ', Nature Communications, vol. 5, 5457 . https://doi.org/10.1038/ncomms6457
Nature Communications, 5:5457. Nature Publishing Group

Response to drug therapy in individual colorectal cancer (CRC) patients is associated with tumour biology. Here we describe the genomic landscape of tumour samples of a homogeneous well-annotated series of patients with metastatic CRC (mCRC) of two p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52e89217113a6a46393270d76db5194
https://pubmed.ncbi.nlm.nih.gov/25394515

Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent

Autor: Leonie J. M. Mekenkamp, Bauke Ylstra, Cornelis J. A. Punt, Patricia van Cleef, Hendrik F. van Essen, Danielle Israeli, Iris D. Nagtegaal, Gerrit A. Meijer, Josien C. Haan, Jeroen R. Dijkstra

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e86833 (2014)
PLoS ONE, 9(2):e86833. Public Library of Science
PLoS One, 9
PLoS One, 9, 2
Mekenkamp, L J M, Haan, J C, Israeli, D, van Essen, H F B, Dijkstra, J R, van Cleef, P, Punt, C J A, Meijer, G A, Nagtegaal, I D & Ylstra, B 2014, ' Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent ', PLoS ONE, vol. 9, no. 2, e86833 . https://doi.org/10.1371/journal.pone.0086833
PLoS ONE, 9(2). Public Library of Science

Contains fulltext : 127561.pdf (Publisher’s version ) (Open Access) The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c224c6dfa90a70cb4f71064999c36a
https://pubmed.ncbi.nlm.nih.gov/24505270

Abstract 3397: Patterns of DNA copy number changes in colorectal cancer metastasis are highly similar to their corresponding primaries with additional focal alterations that differ between individual patients

Autor: Bauke Ylstra, Gerrit A. Meijer, Kees Punt, Iris D. Nagtegaal, Patricia van Cleef, Danielle Israeli, Leonie J. M. Mekenkamp, Jeroen R. Dijkstra, Josien C. Haan

Publikováno v: Cancer Research. 72:3397-3397

Objective: Metastasis is a complex process that remains an obstacle in the management of colorectal cancer (CRC). Over the years many models have been developed to explain the metastatic process in detail, however, the molecular basis is still poorly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41b0da5aea760688cbfd5b0904c1d573
https://doi.org/10.1158/1538-7445.am2012-3397