Supplementary Figure 1 from Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia

Autor: Michael Ohh, Mignon L. Loh, Meredith S. Irwin, Danielle H. Shin, Helene Favre, Julie Weng, Stephanie S. Sybingco, Michelle W. Kang, Severa Bunda

PDF file - 137K, Cbl follows similar temporal course of phosphorylation as GMRβc upon GM-CSF treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8902f26a7a6a9bf067d6761b8317ab93
https://doi.org/10.1158/0008-5472.22399607

Supplementary Table 1 from Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia

Autor: Michael Ohh, Mignon L. Loh, Meredith S. Irwin, Danielle H. Shin, Helene Favre, Julie Weng, Stephanie S. Sybingco, Michelle W. Kang, Severa Bunda

PDF file - 310K, JMML patient-derived primary cell information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11e9f8fad32b339b7a92c0dacf5a628
https://doi.org/10.1158/0008-5472.22399592.v1

Supplementary Figure 2 from Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia

Autor: Michael Ohh, Mignon L. Loh, Meredith S. Irwin, Danielle H. Shin, Helene Favre, Julie Weng, Stephanie S. Sybingco, Michelle W. Kang, Severa Bunda

PDF file - 4783K, Dasatinib inhibits growth of primary JMML cells from patients with CBL, NF1, NRAS, or PTPN11 mutation in a dose dependent manner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f9a04d55e3e388d60a48e4f8aa86ca
https://doi.org/10.1158/0008-5472.22399604

Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia

Autor: Michael Ohh, Meredith S. Irwin, Stephanie S Sybingco, Mignon L. Loh, Helene Favre, Julie Weng, Severa Bunda, Michelle Kang, Danielle H. Shin

Publikováno v: Cancer Research. 73:2540-2550

Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm in children characterized by the overproduction of monocytic cells that infiltrate the spleen, lung, and liver. JMML remains a disease for which few curative therapi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2eb222652441b80cea83575678db14c
https://doi.org/10.1158/0008-5472.can-12-3425

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

Autor: Selim Corbacioglu, Miriam Erlacher, Mignon L. Loh, Danielle H. Shin, Irene Schmid, Peter Lang, Debbie S Sakai, Severa Bunda, Thomas A. Gorr, Michelle Kang, Parinda A. Mehta, Nancy Bunin, Charlotte M. Niemeyer, Ingrid Furlan, Michael Ohh, Paul G. Schlegel, Sophie Archambeault, Marry M Den van Heuvel-Eibrink, Kathleen M. Sakamoto, Michaela Schneider, Christoph Klein, Jan Starý, Andrea Heinzmann, Jerry Z. Finklestein, Christian Flotho, Ryan C. Russell, Franco Locatelli, Henrik Hasle, Benjamin S. Braun, Stephanie S Sybingco, Leslie Chen, Gabriele Kropshofer

Publikováno v: Nature genetics, vol 42, iss 9
Nature Genetics, 9, 794-800. Nature Publishing Group
Nature genetics
Niemeyer, C M, Kang, M W, Shin, D H, Furlan, I, Erlacher, M, Bunin, N J, Bunda, S, Finklestein, J Z, Sakamoto, K M, Gorr, T A, Mehta, P, Schmid, I, Kropshofer, G, Corbacioglu, S, Lang, P J, Klein, C, Schlegel, P-G, Heinzmann, A, Schneider, M, Starý, J, van den Heuvel-Eibrink, M M, Hasle, H, Locatelli, F, Sakai, D, Archambeault, S, Chen, L, Russell, R C, Sybingco, S S, Ohh, M, Braun, B S, Flotho, C & Loh, M L 2010, ' Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia ', Nature Genetics, vol. 42, no. 9, pp. 794-800 . https://doi.org/10.1038/ng.641

c-CBL (CBL) encodes a member of the Cbl family of proteins, which functions as an E3 ubiquitin ligase. We describe a dominant developmental disorder resulting from germline missense CBL mutations, which is characterized by constitutional anomalies th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac128cdee8f7397cacb28c1f0a585ec
https://www.zora.uzh.ch/id/eprint/36009/