Trypanosoma cruzi gene expression in response to gamma radiation.

Autor: Priscila Grynberg, Danielle Gomes Passos-Silva, Marina de Moraes Mourão, Roberto Hirata, Andrea Mara Macedo, Carlos Renato Machado, Daniella Castanheira Bartholomeu, Glória Regina Franco

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29596 (2012)

Trypanosoma cruzi is an organism highly resistant to ionizing radiation. Following a dose of 500 Gy of gamma radiation, the fragmented genomic DNA is gradually reconstructed and the pattern of chromosomal bands is restored in less than 48 hours. Cell

Externí odkaz: https://doaj.org/article/89f6af1aa7064e70bfc3457122596362

The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions.

Autor: Danielle Gomes Passos Silva, Selma da Silva Santos, Sheila C Nardelli, Isabela Cecília Mendes, Anna Cláudia Guimarães Freire, Bruno Marçal Repolês, Bruno Carvalho Resende, Héllida Marina Costa-Silva, Verônica Santana da Silva, Karla Andrade de Oliveira, Camila Franco Batista Oliveira, Liza Figueiredo Felicori Vilela, Ronaldo Alves Pinto Nagem, Glória Regina Franco, Andrea Mara Macedo, Sergio Danilo Junho Pena, Erich Birelli Tahara, Policarpo Ademar Sales Junior, Douglas Souza Moreira, Santuza Maria Ribeiro Teixeira, Richard McCulloch, Stela Virgilio, Luiz Ricardo Orsini Tosi, Sergio Schenkman, Luciana Oliveira Andrade, Silvane Maria Fonseca Murta, Carlos Renato Machado

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006875 (2018)

In Trypanosoma cruzi, the etiologic agent of Chagas disease, Rad51 (TcRad51) is a central enzyme for homologous recombination. Here we describe the different roles of TcRad51 in DNA repair. Epimastigotes of T. cruzi overexpressing TcRAD51 presented a

Externí odkaz: https://doaj.org/article/36c29e39f2654429899460add329f872

The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions

Autor: Glória Regina Franco, Douglas de Souza Moreira, Carlos Renato Machado, Stela Virgilio, Bruno Marçal Repolês, Liza Figueiredo Felicori Vilela, Policarpo Ademar Sales Junior, Anna Cláudia Guimarães Freire, Bruno Carvalho Resende, Luciana O. Andrade, Silvane M. F. Murta, Sergio Schenkman, Karla Andrade de Oliveira, Selma da Silva Santos, Luiz R. O. Tosi, Camila Franco Batista de Oliveira, Erich Birelli Tahara, Veronica Santana da Silva, Sheila Cristina Nardelli, Richard McCulloch, Héllida Marina Costa-Silva, Santuza M. R. Teixeira, Andrea M. Macedo, Sérgio Danilo Junho Pena, Isabela Cecília Mendes, Danielle Gomes Passos Silva, Ronaldo Alves Pinto Nagem

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006875 (2018)

In Trypanosoma cruzi, the etiologic agent of Chagas disease, Rad51 (TcRad51) is a central enzyme for homologous recombination. Here we describe the different roles of TcRad51 in DNA repair. Epimastigotes of T. cruzi overexpressing TcRAD51 presented a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d279aef81ff110e414b899cea4644032

Unveiling benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi

Autor: Matheus Andrade, Rajão, Carolina, Furtado, Ceres Luciana, Alves, Danielle Gomes, Passos-Silva, Michelle Barbi, de Moura, Bruno Luiz, Schamber-Reis, Marianna, Kunrath-Lima, Aline Araújo, Zuma, João Pedro, Vieira-da-Rocha, Juliana Borio Ferreira, Garcia, Isabela Cecília, Mendes, Sérgio Danilo Junho, Pena, Andrea Mara, Macedo, Glória Regina, Franco, Nadja Cristhina, de Souza-Pinto, Marisa Helena Gennari, de Medeiros, Angela Kaysel, Cruz, Maria Cristina Machado, Motta, Santuza Maria Ribeiro, Teixeira, Carlos Renato, Machado

Publikováno v: Environmental and molecular mutagenesis. 55(4)

Benznidazole (BZ) is the most commonly used drug for the treatment of Chagas disease. Although BZ is known to induce the formation of free radicals and electrophilic metabolites within the parasite Trypanosoma cruzi, its precise mechanisms of action

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b5bc56cadc370bf99380d6445eb53ac
https://pubmed.ncbi.nlm.nih.gov/24347026

Estudos sobre os mecanismos de recombinação em trypanosoma cruzi: obtenção e análise de células superexpressando o gene TcRaD51

Autor: Danielle Gomes Passos Silva

Publikováno v: Biblioteca Digital de Teses e Dissertações da UFMGUniversidade Federal de Minas GeraisUFMG.

Trypanosoma cruzi is the parasite that causes Chagas disease. Only a few genes involved in DNA metabolism have been described in this species. Recently, our group characterized a gene encoding one of the key proteins involved in homologous recombinat

Externí odkaz: http://hdl.handle.net/1843/BUOS-8RAJ8F