Výsledky vyhledávání - "Danielle Freches"

Akademický článek

Preclinical evaluation of topically-administered PEGylated Fab’ lung toxicity

Autor: Danielle Freches, Natacha Rocks, Harshad P. Patil, Fabienne Perin, Jacques Van Snick, Rita Vanbever, Didier Cataldo

Publikováno v: International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)

PEGylation is a promising approach to increase the residence time of antibody fragments in the lungs and sustain their therapeutic effects. However, concerns arise as to the potential pulmonary toxicity of antibody fragments conjugated to high molecu

Externí odkaz: https://doaj.org/article/371a5f14a0c8448c99c1d9cb15354492

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Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation

Autor: Gregg A. Duncan, Linda Karmani, Rita Vanbever, Bernard Gallez, Bernard Ucakar, Harshad P. Patil, Danielle Freches, Justin Hanes, Jung Soo Suk

Publikováno v: Journal of Controlled Release. 272:62-71

Pulmonary administration of anti-cytokine antibodies offers a targeted therapy in asthma. However, the rapid elimination of proteins from the lungs limits the efficacy of inhaled medications. PEGylation has been shown to increase the residence time o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f9ab806602287c8cf0d8215fc9ab12b
https://doi.org/10.1016/j.jconrel.2017.12.009

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PEGylation prolongs the pulmonary retention of an anti-IL-17A Fab’ antibody fragment after pulmonary delivery in three different species

Autor: Danielle Freches, Rita Vanbever, Catherine Uyttenhove, Maria Machado Franco, Sam Philip Heywood, Harshad P. Patil

Publikováno v: International Journal of Pharmaceutics. 521:120-129

The PEGylation of antibody fragments has been shown to greatly prolong their residence time in the lungs in mice. The purpose of this research was to confirm the effect of PEGylation in higher animal species, that is, the rat and the rabbit. An anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a075571afda0bba262cdb32600b1ce1
https://doi.org/10.1016/j.ijpharm.2017.02.021

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Preclinical evaluation of topically-administered PEGylated Fab'lung toxicity

Autor: Didier Cataldo, Rita Vanbever, Jacques Van Snick, Danielle Freches, Natacha Rocks, Harshad P. Patil, Fabienne Perin

Publikováno v: International Journal of Pharmaceutcis, (2019)
International Journal of Pharmaceutics: X, Vol 1, Iss, Pp-(2019)
International Journal of Pharmaceutics: X

Graphical abstract
PEGylation is a promising approach to increase the residence time of antibody fragments in the lungs and sustain their therapeutic effects. However, concerns arise as to the potential pulmonary toxicity of antibody fragments c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc175b4584b94912153b058f8ae0a3af
https://hdl.handle.net/2078.1/217930

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Role of B Cells in Host Defense against Primary Coxiella burnetii Infection

Autor: Laura Schoenlaub, Guoquan Zhang, William J. Mitchell, Alexandra Elliott, Danielle Freches

Publikováno v: Infection and Immunity. 83:4826-4836

Despite Coxiella burnetii being an obligate intracellular bacterial pathogen, our recent study demonstrated that B cells play a critical role in vaccine-induced immunity to C. burnetii infection by producing protective antibodies. However, the role o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285d8972028a9ccc2fda5ee203ae3cee
https://doi.org/10.1128/iai.01073-15

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Overexpression of DosR in Mycobacterium tuberculosis does not affect aerobic replication in vitro or in murine macrophages

Autor: Danielle Freches, Nicolas Bruffaerts, Kris Huygen, Gregory Dolganov, Gary K. Schoolnik, Marta Romano, Mario Alberto Flores-Valdez

Publikováno v: Annals of Microbiology. 65:713-720

Mycobacterium tuberculosis H37Rv, constitutively expressing a second copy of the transcriptional regulator DosR (Rv3133c) under control of the hsp60 promoter, was compared to wild-type M. tuberculosis for in vitro expression of the target genes of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4c3bad38c3b39facb4f24e220669f01
https://doi.org/10.1007/s13213-014-0910-3

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Mice genetically inactivated in interleukin-17A receptor are defective in long-term control of Mycobacterium tuberculosis infection

Autor: Danielle Freches, Xavier Havaux, Marta C. Romano, Olivier Denis, Hannelie Korf, Kris Huygen

Summary Interleukin-17A (IL-17A), a pro-inflammatory cytokine acting on neutrophil recruitment, is known to play an important role during Mycobacterium tuberculosis infection, but the role of IL-17A receptor signalling in immune defence against this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22112c7c1cb122f43c6b480c08a20e6a
https://europepmc.org/articles/PMC3784168/

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Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine-treated, Mycobacterium bovis BCG-vaccinated mice

Autor: Danielle Freches, Jacques Van Snick, Kris Huygen, Hannelie Korf, Catherine Uyttenhove, Jean-Christophe Renauld, Marta Romano

Publikováno v: Clinical and Vaccine Immunology, Vol. 18, no. 1, p. 95-104 (2011)

Interleukin-12 (IL-12) and IL-23 (which share a p40 subunit) are pivotal cytokines in the generation of protective Th1/Th17-type immune responses upon infection with the intracellular pathogen Mycobacterium tuberculosis . The role of IL-12 and IL-23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f18677dff535dcf990cd938689caf3
https://pubmed.ncbi.nlm.nih.gov/21084465

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