Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Danielle E. Frodyma"'
Autor:
Danielle E. Frodyma, Thomas C. Troia, Chaitra Rao, Robert A. Svoboda, Jordan A. Berg, Dhananjay D. Shinde, Vinai C. Thomas, Robert E. Lewis, Kurt W. Fisher
Publikováno v:
Cancers, Vol 14, Iss 19, p 4879 (2022)
Background: Previous studies have shown that Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Beta (PGC-1β) and Estrogen-Related Receptor Alpha (ERRα) are over-expressed in colorectal cancer and promote tumor survival. Methods: In th
Externí odkaz:
https://doaj.org/article/f97cbc59fc9241f5b8226676d42e6ca0
Autor:
Beth K. Neilsen, Binita Chakraborty, Jamie L. McCall, Danielle E. Frodyma, Richard L. Sleightholm, Kurt W. Fisher, Robert E. Lewis
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract Background KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcription and DNA synthesi
Externí odkaz:
https://doaj.org/article/771d20c48057472cbc341e4bbb5bf0ab
Autor:
Chaitra Rao, Dianna H. Huisman, Heidi M. Vieira, Danielle E. Frodyma, Beth K. Neilsen, Binita Chakraborty, Suzie K. Hight, Michael A. White, Kurt W. Fisher, Robert E. Lewis
Publikováno v:
Cancers, Vol 12, Iss 11, p 3143 (2020)
Genome-wide, loss-of-function screening can be used to identify novel vulnerabilities upon which specific tumor cells depend for survival. Functional Signature Ontology (FUSION) is a gene expression-based high-throughput screening (GE-HTS) method tha
Externí odkaz:
https://doaj.org/article/eeb7c3c2153f4bf692228d9922603001
Autor:
Chaitra Rao, Danielle E Frodyma, Siddesh Southekal, Robert A Svoboda, Adrian R Black, Chittibabu Guda, Tomohiro Mizutani, Hans Clevers, Keith R Johnson, Kurt W Fisher, Robert E Lewis
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/706ac20d6e23427cb059a67f4a7e21d7
Autor:
Danielle E. Frodyma, Thomas C. Troia, Chaitra Rao, Robert A. Svoboda, Jordan A. Berg, Dhananjay D. Shinde, Vinai C.Thomas, Robert E. Lewis, Kurt W. Fisher
Previous studies have shown that Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Beta (PGC-1β) and Estrogen-Related Receptor Alpha (ERRα) are over-expressed in colorectal cancer and promote tumor survival. In this study, we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca42764ae8da1ed66e9ed5e18482701
https://doi.org/10.1101/2022.05.20.492006
https://doi.org/10.1101/2022.05.20.492006
Autor:
Dianna H. Huisman, Danielle E. Frodyma, Robert A. Svoboda, Heidi M. Vieira, Deepan Chatterjee, Sydney Skupa, James W. Askew, Kurt W. Fisher, Michael S. Kareta, Trudy G. Oliver, Robert E. Lewis
Tumor propagating cells (TPCs) make up a small proportion of tumor cells responsible for self-renewal and long-term propagation of small-cell lung carcinoma (SCLC) tumors. Here, we show that Kinase Suppressor of Ras 2 (KSR2) is an important regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::565a3bc02a0b8f4cf9587c4ca4b35899
https://doi.org/10.1101/2022.02.11.480157
https://doi.org/10.1101/2022.02.11.480157
Autor:
Robert E. Lewis, Robert A. Svoboda, Kurt W. Fisher, Chaitra Rao, Hans Clevers, Chittibabu Guda, Adrian R. Black, Siddesh Southekal, Tomohiro Mizutani, Danielle E. Frodyma, Keith R. Johnson
Publikováno v:
eLife, 10. eLife Sciences Publications
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
eLife
The epithelial-to-mesenchymal transition (EMT) is considered a transcriptional process that induces a switch in cells from a polarized state to a migratory phenotype. Here, we show that KSR1 and ERK promote EMT-like phenotype through the preferential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bb2042ad67232ddc7d12f35e2d41bc
https://pure.knaw.nl/portal/en/publications/a93f93c2-06c8-4529-b2df-02797c4ce103
https://pure.knaw.nl/portal/en/publications/a93f93c2-06c8-4529-b2df-02797c4ce103
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0209224 (2019)
PLoS ONE, Vol 14, Iss 1, p e0209224 (2019)
The cell cycle is under circadian regulation. Oncogenes can dysregulate circadian-regulated genes to disrupt the cell cycle, promoting tumor cell proliferation. As a regulator of G2/M arrest in response to DNA damage, the circadian gene Timeless Circ
Autor:
Binita Chakraborty, Jamie L. McCall, Robert E. Lewis, Kurt W. Fisher, Danielle E. Frodyma, Richard Sleightholm, Beth K. Neilsen
Publikováno v:
BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018)
Background KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcription and DNA synthesis; howeve
Targeting downstream effectors required for oncogenic Ras signaling is a potential alternative or complement to the development of more direct approaches targeting Ras in the treatment of Ras-dependent cancers. Areas covered: Here we review literatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71828d01e2241fc4d6927d367b19d83
https://europepmc.org/articles/PMC5490495/
https://europepmc.org/articles/PMC5490495/