Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip

Autor: Girija Goyal, Pranav Prabhala, Gautam Mahajan, Bruce Bausk, Tal Gilboa, Liangxia Xie, Yunhao Zhai, Roey Lazarovits, Adam Mansour, Min Sun Kim, Aditya Patil, Danielle Curran, Jaclyn M. Long, Sanjay Sharma, Abidemi Junaid, Limor Cohen, Thomas C. Ferrante, Oren Levy, Rachelle Prantil‐Baun, David R. Walt, Donald E. Ingber

Publikováno v: Advanced Science, Vol 9, Iss 14, Pp n/a-n/a (2022)

Abstract Lymphoid follicles (LFs) are responsible for generation of adaptive immune responses in secondary lymphoid organs and form ectopically during chronic inflammation. A human model of ectopic LF formation will provide a tool to understand LF de

Externí odkaz: https://doaj.org/article/72989818cd824b03a101649325a3d3a1

Novel Anticancer NHC*-Gold(I) Complexes Inspired by Lepidiline A

Autor: Danielle Curran, Helge Müller-Bunz, Sofia I. Bär, Rainer Schobert, Xiangming Zhu, Matthias Tacke

Publikováno v: Molecules, Vol 25, Iss 15, p 3474 (2020)

N-Heterocyclic carbene gold(I) complexes derived from 1,3-dibenzyl-4,5-diphenylimidazol-2-ylidene (NHC*) represent a promising class of anticancer drugs. Complexes of the type NHC*-Au-L (L = Br−, I−, C≡C-R) and [NHC*-Au-L]+ (L = NHC*, PPh3) hav

Externí odkaz: https://doaj.org/article/fedd3b340f23485f9814aedf3985cca6

Treatment of Burns in Adult Patients With a Concentrated Surfactant Gel: A Real-life Retrospective Evaluation

Autor: Timothy, Pittinger, Danielle, Curran, Michel, Hermans

Publikováno v: Wounds : a compendium of clinical research and practice. 32(12)

Debridement is often a necessary step in wound care. In burn care, typically, surgery or enzymes are used for this purpose.In a real-life retrospective study, the autolytic debridement properties of a concentrated surfactant gel (CSG) were assessed.T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46ca1c749db4bd04ec99e479a590006c
https://pubmed.ncbi.nlm.nih.gov/33472159

Synthesis and cytotoxicity studies of novel NHC–Gold(I) pseudohalides and thiolates

Autor: Oyinlola Dada, Cillian O'Beirne, Matthias Tacke, Xiangming Zhu, Danielle Curran, Helge Müller-Bunz

Publikováno v: Journal of Organometallic Chemistry. 840:30-37

The synthesis and biological evaluation of three gold pseudohalides and three gold thiolates, stabilised by the NHC ligand 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene (NHC*), in order to form stable gold(I) complexes is reported. Two separate proced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37d712a59906791e41f3668b58141c9a
https://doi.org/10.1016/j.jorganchem.2017.03.050

Synthesis and Cytotoxicity Studies of Novel NHC*-Gold(I) Complexes Derived from Lepidiline A

Autor: Rainer Schobert, Helge Müller-Bunz, Oyinlola Dada, Xiangming Zhu, Danielle Curran, Matthias Rothemund, Matthias Tacke, Goar Sánchez-Sanz

Publikováno v: Molecules
Volume 23
Issue 8
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 8, p 2031 (2018)

Ten novel N-heterocyclic carbene gold(I) complexes derived from lepidiline A (1,3-dibenzyl-4,5-dimethylimidazolium chloride) are reported here with full characterisation and biological testing. (1,3-Dibenzyl-4,5-diphenylimidazol-2-ylidene)gold(I) chl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9160e74042c20d0114c344cbf988e54c
https://doi.org/10.3390/molecules23082031