A continuum model of transcriptional bursting

Autor: Adam M Corrigan, Edward Tunnacliffe, Danielle Cannon, Jonathan R Chubb

Publikováno v: eLife, Vol 5 (2016)

Transcription occurs in stochastic bursts. Early models based upon RNA hybridisation studies suggest bursting dynamics arise from alternating inactive and permissive states. Here we investigate bursting mechanism in live cells by quantitative imaging

Externí odkaz: https://doaj.org/article/1e07e531046c432f99fb9cf8125512f7

Structure of Spherulites in Insulin, β-Lactoglobulin, and Amyloid β

Autor: Stephen J. Eichhorn, Danielle Cannon, Athene M. Donald

Publikováno v: ACS Omega, Vol 1, Iss 5, Pp 915-922 (2016)
ACS Omega
Cannon, D, Eichhorn, SJ & Donald, A 2016, ' Structure of Spherulites in Insulin, β-Lactoglobulin, and Amyloid β ', ACS Omega, vol. 1, pp. 915-922 . https://doi.org/10.1021/acsomega.6b00208

Under denaturing conditions such as low pH and elevated temperatures, proteins in vitro can misfold and aggregate to form long rigid rods called amyloid fibrils; further self-assembly can lead to larger structures termed spherulites. Both of these ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2233ae30d56ab25faba40da27884eb3
https://doi.org/10.1021/acsomega.6b00208

Author response: A continuum model of transcriptional bursting

Autor: Jonathan R. Chubb, Adam M. Corrigan, Danielle Cannon, Edward Tunnacliffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3223983d3b20d4a46a8a59b19abab0db
https://doi.org/10.7554/elife.13051.024

Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity

Autor: Patrick McDonel, Agnes Miermont, Jonathan R. Chubb, Adam M. Corrigan, Danielle Cannon

Much of development and disease concerns the generation of gene expression differences between related cells sharing similar niches. However most analyses of gene expression only assess population and time-averaged levels of steady-state transcriptio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7ef3587f3d10dedce7448b1013d112
https://europepmc.org/articles/PMC4550964/

Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

Autor: Marek Gierlinski, Geoffrey J. Barton, Jonathan R. Chubb, Adam M. Corrigan, Danielle Cannon, Tetsuya Muramoto

Transcription of genes can be discontinuous, occurring in pulses or bursts. It is not clear how properties of transcriptional pulses vary between different genes. We compared the pulsing of five housekeeping and five developmentally induced genes by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f0721aa66b0e07b0e041a79b6018e0
https://europepmc.org/articles/PMC3358836/