Výsledky vyhledávání - "Danielle Caliger"

Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen–Deuterium Exchange Mass Spectrometry

Autor: Kaitlyn A. Sabo, Elene Albekioni, Danielle Caliger, Nalani J. Coleman, Ella Thornberg, Diego Avellaneda Matteo, Elizabeth A. Komives, Steve Silletti, Christal D. Sohl

Publikováno v: Biochemistry

Human isocitrate dehydrogenase 1 (IDH1) is a highly conserved metabolic enzyme that catalyzes the interconversion of isocitrate and α-ketoglutarate. Kinetic and structural studies with IDH1 have revealed evidence of striking conformational changes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5e9a2fc36a00ab4e6472d179efe3c4
https://doi.org/10.1021/acs.biochem.2c00636

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Abstract 3732: Characterization of tumor relevant isocitrate dehydrogenase 1 (IDH1)

Autor: Christal D. Sohl, Lucas A. Luna, Nalani J. Coleman, Danielle Caliger, Ella Thornberg

Publikováno v: Cancer Research. 80:3732-3732

Isocitrate dehydrogenase 1 (IDH1) is found commonly mutated in grade II and III gliomas and secondary glioblastomas. Normally, IDH1 catalyzes the conversion of isocitrate and NADP+ to α-ketoglutarate and NADPH. However, in mutated form, IDH1 catalyz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::383c8fcd4074ddf6a03eb81de4c81e2a
https://doi.org/10.1158/1538-7445.am2020-3732

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