Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

Autor: Natalie M. Niemi, Gary M. Wilson, Katherine A. Overmyer, F.-Nora Vögtle, Lisa Myketin, Danielle C. Lohman, Kathryn L. Schueler, Alan D. Attie, Chris Meisinger, Joshua J. Coon, David J. Pagliarini

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

The mitochondria houses several phosphatases, but their function is not well characterized. Here, the authors show that mitochondrial phosphatase Pptc7 is important during development for proper mitochondrial function and has a role regulating protei

Externí odkaz: https://doaj.org/article/0cc3120d036a46b9807f1cae4a084aeb

An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis

Autor: Stefely, Joshua J. Coon, Erin Weisenhorn, R.W. Smith, Danielle C. Lohman, Adam Jochem, Craig A. Bingman, Vanessa Linke, B. Wancewicz, Jason D. Russell, Emily T. Beebe, David J. Pagliarini, Molly T. McDevitt, Deniz Aydin, M. Dal Peraro, Emily M. Wilkerson, Paul D. Hutchins, H.C. Von Bank

Publikováno v: Molecular cell. 73(4)

The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology. In eukaryotes, CoQ precursors—among nature’s most hydrophobic molecules—must somehow be presented to a series of enzymes peripheral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8404a03d328a8ee9aee9703b35d7ecfe
https://pubmed.ncbi.nlm.nih.gov/31002800

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity

Autor: Catherine E. Minogue, David J. Pagliarini, Floriana Licitra, Anna Isabel Schlagowski, Danielle C. Lohman, Fabien Pierrel, Laurence Reutenauer, Isabel E. Johnson, Joffrey Zoll, Andrew G. Reidenbach, Natarajan Kannan, Pankaj Kumar Singh, Zachary A. Kemmerer, Xiao Guo, Emily M. Wilkerson, Alexander S. Hebert, Jonathan A. Stefely, Matteo Dal Peraro, Paul D. Hutchins, Zheng Ruan, Matthew J. P. Rush, Craig A. Bingman, Nicholas W. Kwiecien, Pavel J. Sindelar, Joshua J. Coon, Adam Jochem, Tiphaine Jaeg-Ehret, Brendan J. Floyd, Anais Grangeray, Arne Ulbrich, Michael S. Westphall, Hélène Puccio, Leila Laredj, Maya Chergova, Philippe Isope, Deniz Aydin, Elyse C. Freiberger, Ulrika Forsman

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2016, 63 (4), pp.608-620. ⟨10.1016/j.molcel.2016.06.030⟩
Molecular Cell, 2016, 63 (4), pp.608-620. ⟨10.1016/j.molcel.2016.06.030⟩

International audience; The UbiB protein kinase-like (PKL) family is widespread, comprising one-quarter of microbial PKLs and five human homologs, yet its biochemical activities remain obscure. COQ8A (ADCK3) is a mammalian UbiB protein associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02f7793b0e6ed23b2f1194f59df5cdd
https://pubmed.ncbi.nlm.nih.gov/27499294

Hydrolysis of N -Alkyl Sulfamates and the Catalytic Efficiency of an S–N Cleaving Sulfamidase

Autor: Danielle C. Lohman, Richard Wolfenden, David R. Edwards

The final step in the degradation of heparin sulfate involves the enzymatic hydrolysis of its 2-sulfamido groups. To evaluate the power of the corresponding sulfamidases as catalysts, we examined the reaction of N-neopentyl sulfamate at elevated temp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f683f74f7130e5add808dd197f4b8b9c

Awareness and Attitudes of Research Students Toward Dual-use Research of Concern in Pakistan: A Cross-sectional Questionnaire.

Autor: Sarwar S; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC., Ilyas S; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC., Khan BA; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC., Lohman DC; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC., Haffez S; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC., Rafique M; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC., Rashid F; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC., Akhtar J; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC., Khan S; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC., Amoah AO; Samreen Sarwar, MPhil, is a doctoral student in microbiology, University of Health Sciences, Lahore, Pakistan. Sadaf Ilyas, MPhil, is a doctoral student, School of Biological Sciences, University of Punjab, Lahore. Bilal Ahmed Khan, MPhil, is Assistant Professor, Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan. Danielle C. Lohman, PhD, is a Policy Fellow, Health Security Partners, Washington, DC. Saleha Haffez is a postgraduate student, Department of Industrial Biotechnology, ASAB, National University of Science and Technology, Islamabad, Pakistan. Madiha Rafique, MPhil, is a Medical Laboratory Technologist, Department of Pathology, Bahawalpur Medical and Dental College, Bahawalpur, Pakistan. Faizan Rashid, MPhil, is Lecturer, Medical Lab Technology, University of Haripur, Haripur, Pakistan. Junaid Akhtar, MPhil, is a Lecturer, Allied Health Sciences, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. Saeed Khan, PhD, is Professor, Department of Pathology, Dow University of Health Sciences, Karachi. Aurora O. Amoah, MPH, MPP, PhD, is Principal Consultant, Data Analytics Research & Evaluation Group, Washington, DC.

Publikováno v: Health security [Health Secur] 2019 May/Jun; Vol. 17 (3), pp. 229-239.