Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Danielle Bucchini"'
Publikováno v:
Diabetologia
Diabetologia, Springer Verlag, 2002, 45 (9), pp.1292-1297. ⟨10.1007/s00125-002-0881-y⟩
Diabetologia, Springer Verlag, 2002, 45 (9), pp.1292-1297. ⟨10.1007/s00125-002-0881-y⟩
Insulin receptor null mutant mice develop severe diabetes, ketoacidosis and liver steatosis and die within 1 week after birth. Since the liver plays an essential role in the control of glucose homeostasis, we examined in this work whether the metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0978e8d3d17aa46e9b6dfa668b7e0d59
https://doi.org/10.1007/s00125-002-0881-y
https://doi.org/10.1007/s00125-002-0881-y
Publikováno v:
Scopus-Elsevier
Neoplastic B cells from H chain disease patients express a truncated B cell receptor (BCR), comprising a membrane Ig that lacks part of its extracellular domain. It has been speculated that deletion of the Ag binding domain would confer a constitutiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14c9e5a6f8a2f181867766548b08cf5
https://doi.org/10.4049/jimmunol.166.5.3083
https://doi.org/10.4049/jimmunol.166.5.3083
Publikováno v:
Genomics. 47:52-57
The mouse gene encoding preproinsulin 2 ( Ins2 ) is located on the distal end of chromosome 7 in a region of several hundred kilobases that contains several imprinted genes. The exclusive expression of the Ins2 paternal allele in the visceral yolk sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d852bbf47d55f9d5098fcc1f0d2a1f27
https://doi.org/10.1006/geno.1997.5070
https://doi.org/10.1006/geno.1997.5070
Autor:
Jacques Jami, Danielle Bucchini, Bertrand Duvillié, Susan Saint-Just, Betty Lamothe, Nathalie Cordonnier, Rajiv L. Joshi, Anne Baudry
Publikováno v:
Molecular and Cellular Biochemistry. 182:161-168
Transgenic and gene targeting approaches have now been applied to a number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic β-cell function in the mouse. The availability of such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1941f896fb92ba301093c2b93c6159fc
https://doi.org/10.1023/a:1006813712567
https://doi.org/10.1023/a:1006813712567
Autor:
Pierrette Desbois, Jean-Michel Itier, Philippe Douhet, Jacques Jami, Rajiv L. Joshi, Françoise Dandoy-Dron, Danielle Bucchini
Publikováno v:
Differentiation
Differentiation, Elsevier, 1996, 60 (5), pp.309-316. ⟨10.1046/j.1432-0436.1996.6050309.x⟩
Differentiation, Elsevier, 1996, 60 (5), pp.309-316. ⟨10.1046/j.1432-0436.1996.6050309.x⟩
A mini-human insulin gene and four derivatives mutated at several regions potentially involved in the regulation of gene expression were used to generate transgenic mouse lines. The effect of these mutations on the efficiency of gene expression and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae1dfe43e323f736c92a58c0fb486e6
https://doi.org/10.1046/j.1432-0436.1996.6050309.x
https://doi.org/10.1046/j.1432-0436.1996.6050309.x
Publikováno v:
Biology of the Cell. 85:137-146
We explored the possibility that an insulin gene deleted in its 5'-flanking region is expressed in adult mouse brain. We used three independent lines of mice carrying a human insulin transgene which included the insulin gene transcription unit flanke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9948c9379dac1cfafc16109fa8319f06
https://doi.org/10.1016/0248-4900(96)85274-9
https://doi.org/10.1016/0248-4900(96)85274-9
Autor:
Niels Blume, Patrick Leduque, Danielle Bucchini, Jacques Jami, Ole D. Madsen, Paul Dubois, Louise Deltour
Publikováno v:
Proceedings of the National Academy of Sciences. 90:527-531
In the mouse, insulin is produced from two similar but nonallelic genes that encode proinsulins I and II. We have investigated expression of these two genes during mouse embryonic development, using a PCR to detect the two gene transcripts and immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2805b64282ffe08f7c494c203e42d35
https://doi.org/10.1073/pnas.90.2.527
https://doi.org/10.1073/pnas.90.2.527
Publikováno v:
Nucleic Acids Research. 19:4925-4929
Ten transgenic mouse lines harboring the -346/-103 fragment of the rat insulin I enhancer linked to a heterologous promoter and a reporter gene (Eins-Ptk-CAT construct) were produced. Expression of the hybrid transgene was essentially observed in pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82733a684fdaca8d7804bbbc06cd8c94
https://doi.org/10.1093/nar/19.18.4925
https://doi.org/10.1093/nar/19.18.4925
Autor:
Danielle Bucchini, Gretta Abou Sleymane, Laëtitia Languille, Loïc Leroux, Alain Ktorza, Susan Saint-Just, Cécile Tourrel-Cuzin, Rajiv L. Joshi, Luciane Lamotte, Melis Karaca, Béatrice Durel
Publikováno v:
Frontiers in bioscience : a journal and virtual library
Frontiers in bioscience : a journal and virtual library, 2007, 12, pp.1586-1593
Frontiers in bioscience : a journal and virtual library, 2007, 12, pp.1586-1593
We have generated transgenic mouse lines expressing exclusively a human INS transgene on an Ins1/Ins2 double knockout (mIKO) background. The transgene expression was driven by either a 4000 bp or a 353 bp promoter. These transgenic lines, designated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9b36fc20795520453b9381d38cec41
https://pubmed.ncbi.nlm.nih.gov/17127405
https://pubmed.ncbi.nlm.nih.gov/17127405
Autor:
Rajiv L. Joshi, Danielle Bucchini, B. Duvillie, Jacques Jami, T. Chrones, C. Currie, D. J. Hill
Publikováno v:
Endocrinology
Endocrinology, Endocrine Society, 2002, 143 (4), pp.1530-1537. ⟨10.1210/endo.143.4.8753⟩
Endocrinology, Endocrine Society, 2002, 143 (4), pp.1530-1537. ⟨10.1210/endo.143.4.8753⟩
The targeted disruption of the two nonallelic insulin genes in mouse was reported previously to result in intrauterine growth retardation, severe diabetes immediately after suckling, and death within 48 h of birth. We have further used these animals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c2ef5685c9e89b8f4adaa4863d3536
https://pubmed.ncbi.nlm.nih.gov/11897712
https://pubmed.ncbi.nlm.nih.gov/11897712