Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Danielle Braggio"'
Autor:
Lucia Casadei, Adarsh Choudhury, Patricia Sarchet, Prashanth Mohana Sundaram, Gonzalo Lopez, Danielle Braggio, Gita Balakirsky, Raphael Pollock, Shaurya Prakash
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 4, Pp n/a-n/a (2021)
Abstract We present a resource‐efficient approach to fabricate and operate a micro‐nanofluidic device that uses cross‐flow filtration to isolate and capture liposarcoma derived extracellular vesicles (EVs). The isolated extracellular vesicles w
Externí odkaz:
https://doaj.org/article/ede2998c3b5143528ae6ecc374830a1a
Autor:
Peter Y. Yu, Gonzalo Lopez, Danielle Braggio, David Koller, Kate Lynn J. Bill, Bethany C. Prudner, Abbie Zewdu, James L. Chen, O. Hans Iwenofu, Dina Lev, Anne M. Strohecker, Joelle M. Fenger, Raphael E. Pollock, Denis C. Guttridge
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-133a was significantl
Externí odkaz:
https://doaj.org/article/5a7c8462c263425f8eac52828354eb0f
Autor:
Gonzalo Lopez, Danielle Braggio, Abeba Zewdu, Lucia Casadei, Kara Batte, Hemant Kumar Bid, David Koller, Peter Yu, Obiajulu Hans Iwenofu, Anne Strohecker, Edwin Choy, Dina Lev, Raphael Pollock
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188859 (2017)
Leiomyosarcoma (LMS) is a malignant soft tissue sarcoma (STS) with a dismal prognosis following metastatic disease. Chemotherapeutic intervention has demonstrated to have modest clinical efficacy with no curative potential in LMS patients. Previously
Externí odkaz:
https://doaj.org/article/e00522856e514f35b2874fa5bbfa7bce
Autor:
Gonzalo Lopez, Kate Lynn J Bill, Hemant Kumar Bid, Danielle Braggio, Dylan Constantino, Bethany Prudner, Abeba Zewdu, Kara Batte, Dina Lev, Raphael E Pollock
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133302 (2015)
HDAC isoform-specific inhibitors may improve the therapeutic window while limiting toxicities. Developing inhibitors against class I isoforms poses difficulties as they share high homology among their catalytic sites; however, HDAC8 is structurally u
Externí odkaz:
https://doaj.org/article/42f73f0ea30642b8b9f512962949c8a6
Autor:
Raphael E. Pollock, Dina Lev, Hemant Bid, Abbie Zewdu, Gonzalo Lopez, Danielle Braggio, Lucia Casadei, Bethany C. Prudner, Alexander J. Lazar, Laurent Debussche, Cedric Barriere, Svetlana Bolshakov, Chad J. Creighton, XiaoYen Ma, Isabelle Meaux, Jeannine Garnett, Kate Lynn J. Bill
Supplementary Data from SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d251c68748b14a1893c47d82ed1439
https://doi.org/10.1158/1078-0432.22457193
https://doi.org/10.1158/1078-0432.22457193
Autor:
Priya Londhe, Kara Batte, Dina Lev, Fernanda Costas Casal de Faria, Raphael E. Pollock, Peter Y. Yu, Anne M. Strohecker, Danielle Braggio, Lucia Casadei, Gonzalo Lopez, David Koller, Abeba Zewdu
Publikováno v:
Oncogene
Wnt/β-catenin signaling is one of the key cascades regulating embryogenesis and tissue homeostasis; it has also been intimately associated with carcinogenesis. This pathway is deregulated in several tumors, including colorectal cancer, breast cancer
Autor:
Gonzalo Lopez, Abeba Zewdu, Dina Lev, Ameya Deshmukh, Danielle Braggio, Federica Calore, Paolo Fadda, Carlo M. Croce, Martin Wabitsch, Jennifer L. Leight, Lucia Casadei, Raphael E. Pollock, Chi Song, Valerie P. Grignol
Publikováno v:
Cancer Research. 79:4911-4922
Dedifferentiated liposarcoma (DDLPS) is frequently diagnosed late, and patients typically respond poorly to treatments. DDLPS is molecularly characterized by wild-type p53 and amplification of the MDM2 gene, which results in overexpression of MDM2 pr
Autor:
Adarsh Choudhury, Danielle Braggio, Lucia Casadei, Patricia Sarchet, Prashanth Mohana Sundaram, Gonzalo Lopez, Raphael E. Pollock, Gita Balakirsky, Shaurya Prakash
Publikováno v:
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Vol 10, Iss 4, Pp n/a-n/a (2021)
Journal of Extracellular Vesicles, Vol 10, Iss 4, Pp n/a-n/a (2021)
We present a resource‐efficient approach to fabricate and operate a micro‐nanofluidic device that uses cross‐flow filtration to isolate and capture liposarcoma derived extracellular vesicles (EVs). The isolated extracellular vesicles were captu
Autor:
Danielle Braggio, Gita Balakirsky, Prashanth Mohana Sundaram, Raphael E. Pollock, Lucia Casadei, Gonzalo Lopez, Shaurya Prakash
Publikováno v:
J Microelectromech Syst
We report on isolation, capture, and subsequent elution for analysis of extracellular vesicles derived from human liposarcoma cell conditioned media, using a multi-layer micro-nanofluidic device operated with tangential flow separation. Our device in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015c35a7538f1b4d80564263eec0248a
https://europepmc.org/articles/PMC7839931/
https://europepmc.org/articles/PMC7839931/
Publikováno v:
Advances in experimental medicine and biology. 1226
The term "adipose tissue" represents a multicellular and multifunctional organ involved in lipid storage, in hormone and temperature regulation, and in the protection of bones and vital organs from impact-based damage. Emerging evidence now suggests