Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.

Autor: Katrin Höland, Danielle Boller, Christian Hagel, Silvia Dolski, András Treszl, Olivier E Pardo, Paulina Cwiek, Fabiana Salm, Zaira Leni, Peter R Shepherd, Beata Styp-Rekowska, Valentin Djonov, André O von Bueren, Karl Frei, Alexandre Arcaro

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94132 (2014)

The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancer and plays a crucial role in glioblastoma biology. We were interested in gaining further insight into the potential of target

Externí odkaz: https://doaj.org/article/cd066ec9eb11427fb22bc81c1f4b6bc9

Supplementary Figures S1-S2 from Targeting the Phosphoinositide 3-Kinase Isoform p110δ Impairs Growth and Survival in Neuroblastoma Cells

Autor: Alexandre Arcaro, Michael A. Grotzer, Angelika Eggert, André O. von Bueren, Tarek Shalaby, Kathrin T. Doepfner, Alexander Schramm, Danielle Boller

Supplementary Figures S1-S2 from Targeting the Phosphoinositide 3-Kinase Isoform p110δ Impairs Growth and Survival in Neuroblastoma Cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1f567caf1a5c642f9915cbe257437a
https://doi.org/10.1158/1078-0432.22439602.v1

Targeting receptor tyrosine kinase signaling in acute myeloid leukemia

Autor: Alexandre Arcaro, Danielle Boller, Kathrin T. Doepfner

Publikováno v: Critical Reviews in Oncology/Hematology. 63:215-230

Acute myeloid leukemia (AML) is a quickly progressing, heterogeneous clonal disorder of hematopoietic progenitor cells. Significant progress in understanding the pathogenesis of AML has been achieved in the past few years. Two major types of genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df980858a5471007d0e8acac96b2d2e
https://doi.org/10.1016/j.critrevonc.2007.05.005

Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma

Autor: Christian Hagel, Valentin Djonov, András Treszl, Silvia Dolski, Paulina Ćwiek, Katrin Höland, Fabiana Salm, Beata Styp-Rekowska, Peter R. Shepherd, Karl Frei, Danielle Boller, Olivier E. Pardo, Zaira Leni, André O. von Bueren, Alexandre Arcaro

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94132 (2014)
PLoS ONE; Vol 9
Höland, Katrin; Boller, Danielle; Hagel, Christian; Dolski, Silvia; Treszl, András; Pardo, Olivier E.; Cwiek, Paulina; Salm, Fabiana; Leni, Zaira; Shepherd, Peter R; Styp-Rekowska, Beata; Djonov, Valentin; von Bueren, André O.; Frei, Karl; Arcaro, Alexandre (2014). Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. PLoS ONE, 9(4), e94132. Public Library of Science 10.1371/journal.pone.0094132
PLoS ONE

The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancer and plays a crucial role in glioblastoma biology. We were interested in gaining further insight into the potential of target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6545687698f2e75c7e1de6d57366adba
http://europepmc.org/articles/PMC3981776?pdf=render

Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition

Autor: Tarek Shalaby, Danielle Boller, Alexandre Arcaro, Ana S Guerreiro, Michael A. Grotzer

Publikováno v: International journal of cancer. 119(11)

The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3de53bb2691cb784463170c3fa91ed
https://pubmed.ncbi.nlm.nih.gov/16988940