Výsledky vyhledávání - "Danielle A. Springer"

Akademický článek

Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice

Autor: Jeeyoung Lee, Heather M. Rogers, Danielle A. Springer, Constance T. Noguchi

Publikováno v: Frontiers in Physiology, Vol 15 (2024)

Introduction: Erythropoietin (EPO) acts primarily in regulating red blood cell production mediated by high EPO receptor (EPOR) expression in erythroid progenitor cells. EPO activity in non-erythroid tissue is evident in mice with EPOR restricted to e

Externí odkaz: https://doaj.org/article/4d829453fbb64fb38188d672d72daf35

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Akademický článek

CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism

Autor: Young Jae Bahn, Hariom Yadav, Paolo Piaggi, Brent S. Abel, Oksana Gavrilova, Danielle A. Springer, Ioannis Papazoglou, Patricia M. Zerfas, Monica C. Skarulis, Alexandra C. McPherron, Sushil G. Rane

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)

Understanding how skeletal muscle fiber proportions are regulated is vital to understanding muscle function. Oxidative and glycolytic skeletal muscle fibers differ in their contractile ability, mitochondrial activity, and metabolic properties. Fiber-

Externí odkaz: https://doaj.org/article/e661227f09e44dff81ed08f7b6f00ce5

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Akademický článek

Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia

Autor: Wing-Hang Tong, Hayden Ollivierre, Audrey Noguchi, Manik C. Ghosh, Danielle A. Springer, Tracey A. Rouault

Publikováno v: Heliyon, Vol 8, Iss 8, Pp e10371- (2022)

Cardiomyopathy is a primary cause of death in Friedreich ataxia (FRDA) patients with defective iron-sulfur cluster (ISC) biogenesis due to loss of functional frataxin and in rare patients with functional loss of other ISC biogenesis factors. The mech

Externí odkaz: https://doaj.org/article/4fee0a2299714c5cb921318028a97d3e

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Akademický článek

OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy

Autor: Mario K. Shammas, Xiaoping Huang, Beverly P. Wu, Evelyn Fessler, Insung Y. Song, Nicholas P. Randolph, Yan Li, Christopher K.E. Bleck, Danielle A. Springer, Carl Fratter, Ines A. Barbosa, Andrew F. Powers, Pedro M. Quirós, Carlos Lopez-Otin, Lucas T. Jae, Joanna Poulton, Derek P. Narendra

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)

Mitochondrial stress triggers a response in the cell’s mitochondria and nucleus, but how these stress responses are coordinated in vivo is poorly understood. Here, we characterize a family with myopathy caused by a dominant p.G58R mutation in the m

Externí odkaz: https://doaj.org/article/ef70aa06d2af4caebf5831735eb5446d

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Akademický článek

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

Autor: Julia C. Liu, Jie Liu, Kira M. Holmström, Sara Menazza, Randi J. Parks, Maria M. Fergusson, Zu-Xi Yu, Danielle A. Springer, Charles Halsey, Chengyu Liu, Elizabeth Murphy, Toren Finkel

Publikováno v: Cell Reports, Vol 16, Iss 6, Pp 1561-1573 (2016)

MICU1 is a component of the mitochondrial calcium uniporter, a multiprotein complex that also includes MICU2, MCU, and EMRE. Here, we describe a mouse model of MICU1 deficiency. MICU1−/− mitochondria demonstrate altered calcium uptake, and deleti

Externí odkaz: https://doaj.org/article/1207530fa94c4946b055c9d99a27f0ff

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Akademický článek

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

Autor: J. Julie Wu, Jie Liu, Edmund B. Chen, Jennifer J. Wang, Liu Cao, Nisha Narayan, Marie M. Fergusson, Ilsa I. Rovira, Michele Allen, Danielle A. Springer, Cory U. Lago, Shuling Zhang, Wendy DuBois, Theresa Ward, Rafael deCabo, Oksana Gavrilova, Beverly Mock, Toren Finkel

Publikováno v: Cell Reports, Vol 4, Iss 5, Pp 913-920 (2013)

We analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse model. Mice with two hypomorphic (mTORΔ/Δ) alleles are viable but express mTOR at approximately 25% of wild-type levels. These animals demonstrate reduced

Externí odkaz: https://doaj.org/article/8213b697016544c1aff5a5dfc267de9f

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Akademický článek

Oxidation of Methionine 77 in Calmodulin Alters Mouse Growth and Behavior

Autor: Méry Marimoutou, Danielle A. Springer, Chengyu Liu, Geumsoo Kim, Rodney L. Levine

Publikováno v: Antioxidants, Vol 7, Iss 10, p 140 (2018)

Methionine 77 in calmodulin can be stereospecifically oxidized to methionine sulfoxide by mammalian methionine sulfoxide reductase A. Whether this has in vivo significance is unknown. We therefore created a mutant mouse in which wild type calmodulin-

Externí odkaz: https://doaj.org/article/e047e7e9a36e4294a3b46788cf83f49a

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