Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Danielle A, Garsin"'
Autor:
Shantanu Guha, Shane A. Cristy, Giuseppe Buda De Cesare, Melissa R. Cruz, Michael C. Lorenz, Danielle A. Garsin
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTFungal resistance to commonly used medicines is a growing public health threat, and there is a dire need to develop new classes of antifungals. We previously described a peptide produced by Enterococcus faecalis, EntV, that restricts Candida
Externí odkaz:
https://doaj.org/article/8c1212e5524a427ca59b18cf3872ef30
Autor:
Mazen Oneissi, Melissa R Cruz, Bernardo Ramírez-Zavala, Elena Lindemann-Perez, Joachim Morschhäuser, Danielle A Garsin, J Christian Perez
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011692 (2023)
The signals that denote mammalian host environments and dictate the activation of signaling pathways in human-associated microorganisms are often unknown. The transcription regulator Rtg1/3 in the human fungal pathogen Candida albicans is a crucial d
Externí odkaz:
https://doaj.org/article/3e24ff7738a7433bbed0362a16129276
Autor:
Melissa R. Cruz, Shane Cristy, Shantanu Guha, Giuseppe Buda De Cesare, Elena Evdokimova, Hiram Sanchez, Dominika Borek, Pedro Miramón, Junko Yano, Paul L. Fidel, Alexei Savchenko, David R. Andes, Peter J. Stogios, Michael C. Lorenz, Danielle A. Garsin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Enterococcus faecalis has been reported to inhibit Candida albicans virulence via secretion of the bacteriocin EntV. Here, the authors present the crystal structure and characterise the antifungal properties of this peptide in numerous in vitro and i
Externí odkaz:
https://doaj.org/article/38ab8757685c4f1c86ec176b1e57ee33
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Invasive fungal infections in humans are generally associated with high mortality, making the choice of antifungal drug crucial for the outcome of the patient. The limited spectrum of antifungals available and the development of drug resista
Externí odkaz:
https://doaj.org/article/1b0d9590b03b46139acd6c7901d2bde6
Autor:
Armand O Brown, Danielle A Garsin
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1009021 (2020)
Externí odkaz:
https://doaj.org/article/2e652e3600614cdd872f1179d778e016
Autor:
Armand O. Brown, Carrie E. Graham, Melissa R. Cruz, Kavindra V. Singh, Barbara E. Murray, Michael C. Lorenz, Danielle A. Garsin
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Enterococcus faecalis, a Gram-positive bacterium, and Candida albicans, a polymorphic fungus, are common constituents of the microbiome as well as increasingly problematic causes of infections. Interestingly, we previously showed that these
Externí odkaz:
https://doaj.org/article/3770f5e545754a4a8fdfd990b4b0f751
Autor:
Ángela Sanzo-Machuca, José Manuel Monje Moreno, Rafael Casado-Navarro, Ozgur Karakuzu, David Guerrero-Gómez, Juan Carlos Fierro-González, Peter Swoboda, Manuel J. Muñoz, Danielle A. Garsin, José Rafael Pedrajas, Arantza Barrios, Antonio Miranda-Vizuete
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
Thioredoxins (TRX) are traditionally considered as enzymes catalyzing redox reactions. However, redox-independent functions of thioredoxins have been described in different organisms, although the underlying molecular mechanisms are yet unknown. We r
Externí odkaz:
https://doaj.org/article/d6afa2f126bd48da8c460e932d8047cf
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007944 (2019)
Heme-containing peroxidases are important components of innate immunity. Many of them functionally associate with NADPH oxidase (NOX)/dual oxidase (DUOX) enzymes by using the hydrogen peroxide they generate in downstream reactions. Caenorhabditis ele
Externí odkaz:
https://doaj.org/article/49608ace9a564bdca7b9b250e4a0bf53
Autor:
Truc Thanh Luong, Minh Tan Nguyen, Yi-Wei Chen, Chungyu Chang, Ju Huck Lee, Manuel Wittchen, HyLam Ton-That, Melissa Cruz, Danielle A. Garsin, Asis Das, Andreas Tauch, Hung Ton-That
Publikováno v:
Microorganisms, Vol 9, Iss 2, p 389 (2021)
Controlled RNA degradation is a crucial process in bacterial cell biology for maintaining proper transcriptome homeostasis and adaptation to changing environments. mRNA turnover in many Gram-positive bacteria involves a specialized ribonuclease calle
Externí odkaz:
https://doaj.org/article/202e6fe559b04a48919b9efcb3633829
Autor:
Karan Gautam Kaval, Kavindra V. Singh, Melissa R. Cruz, Sruti DebRoy, Wade C. Winkler, Barbara E. Murray, Danielle A. Garsin
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Enterococcus faecalis is paradoxically a dangerous nosocomial pathogen and a normal constituent of the human gut microbiome, an environment rich in ethanolamine. E. faecalis carries the eut (ethanolamine utilization) genes, which enable the
Externí odkaz:
https://doaj.org/article/64653fa2c8f942b09a46ef17c1a58a57