Výsledky vyhledávání - "Daniella Vullo"

Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff’s bases incorporating sulfonamide, carboxylate and carboxymethyl moieties

Autor: Jean-Yves Winum, Alina Cristian, Claudiu T. Supuran, Daniella Vullo, Mihail Barboiu, Gihane Nasr

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2014, 22 (10), pp.2867-2874. ⟨10.1016/j.bmc.2014.03.041⟩

A library of Schiff bases was synthesized by condensation of aromatic amines incorporating sulfonamide, carboxylic acid or carboxymethyl functionalities as Zn2+-binding groups, with aromatic aldehydes incorporating tert-butyl, hydroxy and/or methoxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200610ebd1124f562ec3f224b9771244
https://doi.org/10.1016/j.bmc.2014.03.041

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Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series

Autor: Claudiu T. Supuran, Joanna Ombouma, Daniella Vullo, Jean-Yves Winum, Pascal Dumy

Publikováno v: ACS Medicinal Chemistry Letters. 6:819-821

A general approach for the synthesis of carbonic anhydrases glycoinhibitors belonging to an aminoxysulfonamide series is presented using a Ferrier sulfonamidoglycosylation reaction on glycals. All the compounds showed good in vitro inhibitory activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68059db4f1b846b62684a06b28ca132
https://doi.org/10.1021/acsmedchemlett.5b00175

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Carbonic anhydrase inhibitors: Synthesis and inhibition of the human carbonic anhydrase isoforms I II VII IX and XII with benzene sulfonamides incorporating 4 5 6 7-tetrabromophthalimide moiety

Autor: Claudiu T. Supuran, Fabrizio Carta, Saurabh M. Verma, Kalyan K. Sethi, Daniella Vullo, Muhammet Tanc

Publikováno v: Bioorganic & Medicinal Chemistry; Vol 21
Bioorganic & Medicinal Chemistry

A series of 4,5,6,7-tetrabromo-1,3-dioxoisoindolin-2-yl benzenesulfonamide derivatives (compounds 1-8) was synthesized by reaction of benzene sulfonamide derivatives with 4,5,6,7-tetrabromophthalic anhydride moiety. These new sulfonamides were invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2eaa43335ae81a09b626e702ce6cc4

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Metallocene-Based Inhibitors of Cancer-Associated Carbonic Anhydrase Enzymes IX and XII

Autor: Julia Morizzi, Daniella Vullo, Quoc Wu, Michael Lloyd Williams, Claudiu T. Supuran, Adam John Salmon, Susan A. Charman, Sally-Ann Poulsen, Daniel John Gregg

Publikováno v: Journal of Medicinal Chemistry; Vol 55
Journal of Medicinal Chemistry

In this study, 20 metallocene-based compounds comprising extensive structural diversity were synthesized and evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. These compounds proved moderate to good CA inhibitors in vitro, with several com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7080f92489d9e6a759465f4bb9cda4

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ChemInform Abstract: Superacid Synthesized Tertiary Benzenesulfonamides and Benzofuzed Sultams Act as Selective hCA IX Inhibitors: Toward Understanding a New Mode of Inhibition by Tertiary Sulfonamides

Autor: Benoît Métayer, Claudiu T. Supuran, Sébastien Thibaudeau, Daniella Vullo, Agnès Martin-Mingot

Publikováno v: ChemInform. 45

A series of tertiary, fluorinated benzenesulfamides (II) is synthesized in superacid HSbF6.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb5b161c3fe902fc24a27903ed28f791
https://doi.org/10.1002/chin.201412176

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Superacid synthesized tertiary benzenesulfonamides and benzofuzed sultams act as selective hCA IX inhibitors: toward understanding a new mode of inhibition by tertiary sulfonamides

Autor: Benoît Métayer, Claudiu T. Supuran, Sébastien Thibaudeau, Agnès Martin-Mingot, Daniella Vullo

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2013, 11 (43), pp.7540-7549. ⟨10.1039/c3ob41538d⟩
Organic & Biomolecular Chemistry; Vol 11
Organic & Biomolecular Chemistry

International audience; A series of tertiary (fluorinated) benzenesulfonamides was synthesized in superacid HF-SbF5. To circumvent the problem of the in situ iminium ion formation, proved by low temperature NMR experiments, a tandem superacid catalys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac66b0f40d75fff52b3b555ef1c06196
https://hal.archives-ouvertes.fr/hal-00964957

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A prodrug approach toward cancer-related carbonic anhydrase inhibition

Autor: Kasiram Katneni, Laurent Bornaghi, Claudiu T. Supuran, Susan A. Charman, Cindy J. Carroux, Gregory M. Rankin, Sally-Ann Poulsen, Janina Moeker, Julia Morizzi, Daniella Vullo

Publikováno v: Journal of Medicinal Chemistry; Vol 56
Journal of Medicinal Chemistry

The selective inhibition of cancer-associated human carbonic anhydrase (CA) enzymes, specifically CA IX and XII, has been validated as a mechanistically novel approach toward personalized cancer management. Herein we report the design and synthesis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c8d8c93a376ddce6116cbc1549a50c
https://pubmed.ncbi.nlm.nih.gov/24200125

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Natural product hybrid and its superacid synthesized analogues: Dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV'

Autor: Jérôme Marrot, Jean-Marie Coustard, Clarisse Vandebrouck, Jocelyn Bescond, Daniella Vullo, Maurice Ouedraogo, Grégoire Carré, Hélène Carreyre, Claudiu T. Supuran, Sébastien Thibaudeau

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2013, 21, pp.3790-3794. ⟨10.1016/j.bmc.2013.04.041⟩
Bioorganic & Medicinal Chemistry; Vol 21
Bioorganic & Medicinal Chemistry

The natural product dodoneine (a dihydropyranone phenolic compound), extracted from African mistletoe Agelanthus dodoneifolius, has been investigated as inhibitor of several human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms. By using superacid chem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6084252f5e9831bc207e0a9cd8306f55
https://hal.archives-ouvertes.fr/hal-00917277

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New superacid synthesized (fluorinated) tertiary benzenesulfonamides acting as selective hCA IX inhibitors: toward a new mode of carbonic anhydrase inhibition by sulfonamides

Autor: Benoît Métayer, Agnès Mingot, Daniella Vullo, Claudiu T. Supuran, Sébastien Thibaudeau

Publikováno v: Chemical Communications; Vol 49
Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2013, 49, pp.6015. ⟨10.1039/c3cc40858b⟩

International audience; Tertiary substituted (fluorinated) benzenesulfonamides were synthesized in superacid HF/SbF5 and tested as inhibitors of human carbonic anhydrases (hCAs, EC 4.2.1.1). Strong selectivity toward tumorassociated hCA IX, without i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5ea12ab0e0c103c6e7c4516cbb098c

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