Limited Short-Term Evolution of SARS-CoV-2 RNA-Dependent RNA Polymerase under Remdesivir Exposure in Upper Respiratory Compartments

Autor: Vladimir Novitsky, Curt G. Beckwith, Kristin Carpenter-Azevedo, Jimin Shin, Joel Hague, Soya Sam, Jon Steingrimsson, Richard C. Huard, Kevin Lethbridge, Sujata Sahu, Kim Rapoza, Karen Chandran, Lauri Bazerman, Evelyn Hipolito, Isabella Diaz, Daniella Carnevale, August Guang, Fizza Gillani, Angela M. Caliendo, Rami Kantor

Publikováno v: Viruses, Vol 16, Iss 10, p 1511 (2024)

Background: The extent of the SARS-CoV-2 short-term evolution under Remdesivir (RDV) exposure and whether it varies across different upper respiratory compartments are not fully understood. Methods: Patients hospitalized for COVID-19, with or without

Externí odkaz: https://doaj.org/article/005daa559d074e6da1c0ad9beee52afc

Limited Short-Term Evolution of SARS-CoV-2 RNA-Dependent RNA Polymerase under Remdesivir Exposure in Upper Respiratory Compartments.

Autor: Novitsky, Vladimir¹ (AUTHOR) vnovitsky@lifespan.org, Beckwith, Curt G.¹ (AUTHOR) cbeckwith@lifespan.org, Carpenter-Azevedo, Kristin² (AUTHOR) kristin.azevedo@health.ri.gov, Shin, Jimin³ (AUTHOR) jimin_shin@alumni.brown.edu, Hague, Joel¹ (AUTHOR) jhague@lifespan.org, Sam, Soya¹ (AUTHOR) ssam2@lifespan.org, Steingrimsson, Jon⁴ (AUTHOR) jon_steingrimsson@brown.edu, Huard, Richard C.² (AUTHOR) richard.huard@health.ri.gov, Lethbridge, Kevin⁵ (AUTHOR) klethbridge@lifespan.org, Sahu, Sujata⁶ (AUTHOR) sujata.sahu@lifespan.org, Rapoza, Kim⁶ (AUTHOR) krapoza1@lifespan.org, Chandran, Karen⁶ (AUTHOR) kchandran@lifespan.org, Bazerman, Lauri⁶ (AUTHOR) lbazerman@lifespan.org, Hipolito, Evelyn⁵ (AUTHOR) ehipolito@lifespan.org, Diaz, Isabella⁵ (AUTHOR) idiaz2@lifespan.org, Carnevale, Daniella⁵ (AUTHOR) dcarnevale3@lifespan.org, Guang, August⁷ (AUTHOR) august_guang@brown.edu, Gillani, Fizza^1,5 (AUTHOR) fgillani@lifespan.org, Caliendo, Angela M.¹ (AUTHOR) angela.caliendo@brownphysicians.org, Kantor, Rami¹ (AUTHOR) rkantor@brown.edu

Publikováno v: Viruses (1999-4915). Oct2024, Vol. 16 Issue 10, p1511. 14p.