Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Daniele Perna"'
Autor:
Pasquale Striano, Alessandro Orsini, Diego Peroni, Daniele Perna, Alice Bonuccelli, Mariagrazia Esposito
Publikováno v:
Journal of Translational Genetics and Genomics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0dade9a74eaadf2411e0d905f7fca60
https://doi.org/10.20517/jtgg.2018.14
https://doi.org/10.20517/jtgg.2018.14
Autor:
Mirko Doni, Stefano Campaner, Daniele Perna, Lars-Gunnar Larsson, Per Hydbring, Bruno Amati, Alessandro Verrecchia, Mariano Barbacid, Matilde Murga, Oscar Fernandez-Capetillo, Susanna Tronnersjö, Thomas Schleker, Lucia Bianchi, Domenico Sardella
Publikováno v:
Nature Cell Biology. 12:54-59
Activated oncogenes induce compensatory tumour-suppressive responses, such as cellular senescence or apoptosis, but the signals determining the main outcome remain to be fully understood. Here, we uncover a role for Cdk2 (cyclin-dependent kinase 2) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1817fa4c884cda314feb351b97f505
https://doi.org/10.1038/ncb2004
https://doi.org/10.1038/ncb2004
A positive role for Myc in TGFβ-induced Snail transcription and epithelial-to-mesenchymal transition
Autor:
Giovanni Fagà, A.P. Smith, Bruno Amati, Ernesto Guccione, Francesca Martinato, Mirko Doni, Daniele Perna, Alessandro Verrecchia
Publikováno v:
Oncogene. 28:422-430
Myc and transforming growth factor-beta (TGFbeta) signaling are mutually antagonistic, that is Myc suppresses the activation of TGFbeta-induced genes, whereas TGFbeta represses c-myc transcription. Here, we report a positive role for Myc in the TGFbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3fc32d6af2f84fcfb97f764395bdb7
https://doi.org/10.1038/onc.2008.395
https://doi.org/10.1038/onc.2008.395
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Autor:
Samantha Bennett, Alessandro Verrecchia, Nelofer Syed, Tim Crook, Paolo Nuciforo, John Lough, Maria Capra, Stefano Confalonieri, Massimo Squatrito, Chiara Luise, Sabine Mai, Milena Gasco, Matteo Cesaroni, Daniele Perna, Eugenio Scanziani, Bruno Amati, Chiara Gorrini, Francesco Marchesi, Domenico Sardella, Francesca Martinato, Landon Wark
Publikováno v:
Nature. 448:1063-1067
The acetyl-transferase Tip60 might influence tumorigenesis in multiple ways. First, Tip60 is a co-regulator of transcription factors that either promote or suppress tumorigenesis, such as Myc and p53. Second, Tip60 modulates DNA-damage response (DDR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d088f2354bb66b18f7813c10f70632a6
https://doi.org/10.1038/nature06055
https://doi.org/10.1038/nature06055
Autor:
David J. Adams, Pedro A. Perez-Mancera, Francesco Iorio, Alistair G. Rust, Florian A. Karreth, Daniele Perna, Constantine Alifrangis, Gideon Bollag, Mamunur Rashid, David A. Tuveson, Mark J. Arends, Marcus Bosenberg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Perna, D, Karreth, F A, Rust, A G, Perez-Mancera, P A, Rashid, M, Iorio, F, Alifrangis, C, Arends, M J, Bosenberg, M W, Bollag, G, Tuveson, D A & Adams, D J 2015, ' BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model ', Proceedings of the National Academy of Sciences, vol. 112, no. 6, pp. E536-E545 . https://doi.org/10.1073/pnas.1418163112
Perna, D, Karreth, F A, Rust, A G, Perez-Mancera, P A, Rashid, M, Iorio, F, Alifrangis, C, Arends, M J, Bosenberg, M W, Bollag, G, Tuveson, D A & Adams, D J 2015, ' BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model ', Proceedings of the National Academy of Sciences, vol. 112, no. 6, pp. E536-E545 . https://doi.org/10.1073/pnas.1418163112
BRAF (v-raf murine sarcoma viral oncogene homolog B) inhibitors elicit a transient anti-tumor response in ∼80% of BRAFV600-mutant melanoma patients that almost uniformly precedes the emergence of resistance. Here we used a mouse model of melanoma i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd62d1a42e9458f4235091993e462d35
http://livrepository.liverpool.ac.uk/3100661/1/PNAS_2015.pdf
http://livrepository.liverpool.ac.uk/3100661/1/PNAS_2015.pdf
Autor:
Antonia L. Pritchard, Constantine Alifrangis, Mamunur Rashid, Carla Daniela Robles-Espinoza, Daniele Perna, Kim Wong, Nicholas K. Hayward, Mathew J. Garnett, Marco Ranzani, Ultan McDermott, David J. Adams, Ken Dutton-Regester
Publikováno v:
Pigment Cell & Melanoma Research
Dear Editor, Despite recent advances in the management of metastatic melanoma using targeted therapies, options for patients with tumours that are BRAF and NRAS wild type remain limited (Dummer et al., 2012). BRAF/NRAS wild-type melanoma accounts for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdd6ff4d7b463fdd8cbbed42b53967c
https://pubmed.ncbi.nlm.nih.gov/25243813
https://pubmed.ncbi.nlm.nih.gov/25243813
Autor:
Pier Paolo Pandolfi, Ruth Halaban, Florian A. Karreth, Paolo Provero, Ugo Ala, Pedro A. Perez-Mancera, Dror Weiss, Shen Mynn Tan, Michael Krauthammer, Alistair G. Rust, Gina M. DeNicola, David J. Adams, David A. Tuveson, Kaitlyn A. Webster, Yvonne Tay, Daniele Perna
Publikováno v:
Cell. 147(4)
SummaryWe recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs to regulate mRNA transcripts containing common microRNA recognition elements (MREs). However, the functional role of ceRNAs in cancer remains unknown. Loss of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d572cf3ea0bd466340c3fcd22af1f6b1