Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Daniele Passarella"'
Autor:
Luca Pinzi, Christian Conze, Nicolo Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I. Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig, Michael S. Christodoulou, Daniele Passarella, Lidia Bakota, Giulio Rastelli, Roland Brandt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Tauopathies such as Alzheimer’s disease are characterized by aggregation and increased phosphorylation of the microtubule-associated protein tau. Tau’s pathological changes are closely linked to neurodegeneration, making tau a prime cand
Externí odkaz:
https://doaj.org/article/46bfa35f5bc64145adbe0445e00ba099
Autor:
Francesca Foschi, Annachiara Tinivella, Valentina Crippa, Luca Pinzi, Luca Mologni, Daniele Passarella, Giulio Rastelli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 239-245 (2023)
EGFR is a protein kinase whose aberrant activity is frequently involved in the development of non-small lung cancer (NSCLC) drug resistant forms. The allosteric inhibition of this enzyme is currently one among the most attractive approaches to design
Externí odkaz:
https://doaj.org/article/25d2bf8ec18e40be90168dfa859cc71c
Autor:
Elif Merve Aydin, İdil Su Canıtez, Eleonora Colombo, Salvatore Princiotto, Daniele Passarella, Sabrina Dallavalle, Michael S. Christodoulou, Irem Durmaz Şahin
Publikováno v:
Molecules, Vol 28, Iss 23, p 7777 (2023)
Ovarian cancer ranks as the eighth most prevalent form of cancer in women across the globe and stands as the third most frequent gynecological cancer, following cervical and endometrial cancers. Given its resistance to standard chemotherapy and high
Externí odkaz:
https://doaj.org/article/0af8e3e1500c4e7b817f0031040fe118
Autor:
Andrea Citarella, Alessandro Dimasi, Davide Moi, Daniele Passarella, Angela Scala, Anna Piperno, Nicola Micale
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1339 (2023)
The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target. Disruption of the catalytic activity of Mpro produces a detrimental ef
Externí odkaz:
https://doaj.org/article/00eeeba6b2bc47d191e6df9db6aefe8d
Autor:
Antonia I. Antoniou, Giulia Nordio, Maria Luisa Di Paolo, Eleonora Colombo, Beatrice Gaffuri, Laura Polito, Arianna Amenta, Pierfausto Seneci, Lisa Dalla Via, Dario Perdicchia, Daniele Passarella
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 722 (2023)
A potent nontoxic antitumor drug, 2-hydroxyoleic acid (6, 2OHOA) used for membrane lipid therapy, was selected as a self-assembly inducer due to its ability to form nanoparticles (NPs) in water. For this purpose, it was conjugated with a series of an
Externí odkaz:
https://doaj.org/article/989a683bcee348109029a8979ddd23b4
Autor:
Martina Pedrini, Angelo Iannielli, Lorenzo Meneghelli, Daniele Passarella, Vania Broccoli, Pierfausto Seneci
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1467 (2023)
The search for disease-modifying agents targeted against Parkinson’s disease led us to rationally design a small array of six Anle138b-centered PROTACs, 7a,b, 8a,b and 9a,b, targeting αSynuclein (αSyn) aggregates for binding, polyubiquitination b
Externí odkaz:
https://doaj.org/article/891a2a22e7a74a898474afba10a7f648
Autor:
Andrea Citarella, Davide Moi, Martina Pedrini, Helena Pérez-Peña, Stefano Pieraccini, Claudio Stagno, Nicola Micale, Tanja Schirmeister, Giulia Sibille, Giorgio Gribaudo, Alessandra Silvani, Daniele Passarella, Clelia Giannini
Publikováno v:
Molecules, Vol 28, Iss 2, p 514 (2023)
SARS-CoV-2 Mpro is a chymotrypsin-like cysteine protease playing a relevant role during the replication and infectivity of SARS-CoV-2, the coronavirus responsible for COVID-19. The binding site of Mpro is characterized by the presence of a catalytic
Externí odkaz:
https://doaj.org/article/fd5e75a5ccd442329d507b6342d1c2af
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15960 (2022)
In the panorama of sustainable chemistry, the use of green solvents is increasingly emerging for the optimization of more eco-friendly processes which look to a future of biocompatibility and recycling. The green solvent Cyrene, obtained from biomass
Externí odkaz:
https://doaj.org/article/2d3bb69c384b4565900857eb54e8a443
Autor:
Eleonora Colombo, Davide Andrea Coppini, Laura Polito, Umberto Ciriello, Giuseppe Paladino, Mariafrancesca Hyeraci, Maria Luisa Di Paolo, Giulia Nordio, Lisa Dalla Via, Daniele Passarella
Publikováno v:
Molecules, Vol 28, Iss 1, p 112 (2022)
Cannabidiol (CBD) is a biologically active compound present in the plants of the Cannabis family, used as anticonvulsant, anti-inflammatory, anti-anxiety, and more recently, anticancer drug. In this work, its use as a new self-assembly inducer in the
Externí odkaz:
https://doaj.org/article/7788ff85d66948a09ccdfe792ebb7e47
Autor:
Sabrina Giofrè, Antonio Renda, Silvia Sesana, Beatrice Formicola, Barbara Vergani, Biagio Eugenio Leone, Vanna Denti, Giuseppe Paglia, Serena Groppuso, Valentina Romeo, Luca Muzio, Andrea Balboni, Andrea Menegon, Antonia Antoniou, Arianna Amenta, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2402 (2022)
Dual functionalized liposomes were developed to cross the blood–brain barrier (BBB) and to release their cargo in a pathological matrix metalloproteinase (MMP)-rich microenvironment. Liposomes were surface-functionalized with a modified peptide der
Externí odkaz:
https://doaj.org/article/c466099e0aa34384bb4a567dc44eff87