Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniele M. Leonard"'
Autor:
Noel A. Powell, Joseph E. Duran, Timothy J. Hagen, Robert M. Kennedy, Fred L. Ciske, Daniel D. Holsworth, Cuiman Cai, Jeremy J. Edmunds, Daniele M. Leonard
Publikováno v:
Tetrahedron Letters. 51:4441-4444
We have optimized the Pd-catalyzed intramolecular α-arylation of 2-(2-halo-benzyl)-cyclohexanones and found that the use of 2-(dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl (X-Phos) as an added ligand led to a reproducible, effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9638ff892a3e7619ecfabc921fb66316
https://doi.org/10.1016/j.tetlet.2010.06.085
https://doi.org/10.1016/j.tetlet.2010.06.085
Autor:
Daniele M. Leonard, Richard Gowan, Karen K. Zimmerman, Maritza Oxender, Judith Sebolt-Leopold, Jeffrey D. Scholten, Donald Hupe
Publikováno v:
Journal of Biological Chemistry. 272:18077-18081
Investigation of the comparative activities of various inhibitors of farnesyl:protein transferase (FPTase) has led to the observation that the presence of phosphate or pyrophosphate ions in the assay buffer increases the potency of farnesyl diphospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1828852d294eb0d68317031a9b08af4
https://doi.org/10.1074/jbc.272.29.18077
https://doi.org/10.1074/jbc.272.29.18077
Autor:
Jeffrey D. Scholten, Maritza Oxender, Judith Sebolt-Leopold, Daniele M. Leonard, Richard C. Gowan, Karen K. Zimmerman, Donald Hupe
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:1537-1543
The recent interest in inhibitors of farnesyl:protein transferase (FPTase) has resulted in a better understanding of the enzymology of this protein. Rationally designed inhibitors of prenyl transfer have emerged as potential new drug candidates becau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d037b69cdff6432bd7b8c68c669bf46d
https://doi.org/10.1016/0968-0896(96)00146-0
https://doi.org/10.1016/0968-0896(96)00146-0
Autor:
M. A. Flynn, Daniele M. Leonard, E. E. Reynolds, Kristen E. Hill, Katherine E. Holub, James B. Dunbar, Michael D. Reily, Annette Marian Doherty, Kathleen M. Welch, Wayne L. Cody
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:967-972
A series of endothelin-1 [16–21] analogs, designed to incorporate random coil and β-turn conformations, was synthesized. Compounds were compared for their endothelin receptor binding affinity and functional activity relative to the native sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbeef8e7dc386651f91544a6de02eacd
https://doi.org/10.1016/0960-894x(95)00152-j
https://doi.org/10.1016/0960-894x(95)00152-j
Autor:
M. A. Flynn, John X. He, James B. Dunbar, Annette Marian Doherty, Kristen E. Hill, Wayne L. Cody, Daniele M. Leonard, P. L. DePue, E. E. Reynolds
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:497-502
We have previously described structure-activity relationships in the hydrophobic C-terminal hexapeptide region of ET-1 known to be highly important for receptor recognition. A mono- D -amino acid scan of ET[16–21] revealed that a D-His16 substituti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::100806efbd58b823c63fd2cf37565091
https://doi.org/10.1016/s0960-894x(01)81215-4
https://doi.org/10.1016/s0960-894x(01)81215-4
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15a39e9b30f9d5cca3f91c08b799fd61
https://doi.org/10.1002/chin.199525264
https://doi.org/10.1002/chin.199525264
Autor:
Daniele M. Leonard
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b502635fd0462cba89c2d3880764e9d
https://doi.org/10.1002/chin.199752290
https://doi.org/10.1002/chin.199752290
Autor:
C. Fiakpui, Shaoyi Sun, Nancy Janiczek, Frances La, Gary Louis Bolton, Samarendra N. Maiti, J. Thomas Peterson, John W. Bryant, Raman Sharma, Neerja Saraswat, Jeremy J. Edmunds, Shrilakshmi Desiraju, Vaishali Sahasrabudhe, Kathleen M. Welch, Staci Haarer, Erli Zhang, Jeffrey T. Kohrt, Daniele M. Leonard, Christopher F. Bigge, Robert J. Leadley, Hena Mostafa, Tawny K. Dahring, Wayne L. Cody, Kevin J. Filipski, Lakshmi Narasimhan
Publikováno v:
Bioorganicmedicinal chemistry. 14(13)
Herein, we report on the identification of three potent glycine and related amino acid-based series of FXa inhibitors containing a neutral P1 chlorophenyl pharmacophore. A X-ray crystal structure has shown that constrained glycine derivatives with op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e151762b0e758c71839c611c25846609
https://pubmed.ncbi.nlm.nih.gov/16529937
https://pubmed.ncbi.nlm.nih.gov/16529937
Autor:
Kevon R. Shuler, Daniele M. Leonard, Jeffrey D. Scholten, Dennis Joseph Mcnamara, Judith Sebolt-Leopold, Annette Marian Doherty
Publikováno v:
American Peptide Symposia ISBN: 0792351606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e93f73e34985beeb6badb56224b816b1
https://doi.org/10.1007/0-306-46862-x_85
https://doi.org/10.1007/0-306-46862-x_85
Autor:
Dennis Joseph Mcnamara, M. Creswell, Kevon R. Shuler, Annette Marian Doherty, Robert L. Panek, Wayne L. Cody, Gary Louis Bolton, Daniele M. Leonard, Judith Sebolt-Leopold, Scott R. Eaton, Jeffrey D. Scholten
Publikováno v:
Chinese Peptide Symposia ISBN: 0792349636
There has been considerable progress in elucidating the mechanisms by which extracellular signals are transduced via cell surface receptors to trigger changes in gene expression determining the growth and differentiated state of the cell. Efforts to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b7b62ddd8751667fe5bce03be3dc738
https://doi.org/10.1007/0-306-46859-x_12
https://doi.org/10.1007/0-306-46859-x_12