Výsledky vyhledávání - "Daniele Lorenzini"

Akademický článek

Prevalence of BRCA homopolymeric indels in an ION Torrent-based tumour-to-germline testing workflow in high-grade ovarian carcinoma

Autor: Jacopo Azzollini, Luca Agnelli, Elena Conca, Tommaso Torelli, Adele Busico, Iolanda Capone, Marta Angelini, Elena Tamborini, Federica Perrone, Andrea Vingiani, Daniele Lorenzini, Bernard Peissel, Giancarlo Pruneri, Siranoush Manoukian

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)

Abstract Tumour DNA sequencing is essential for precision medicine since it guides therapeutic decisions but also fosters the identification of patients who may benefit from germline testing. Notwithstanding, the tumour-to-germline testing workflow p

Externí odkaz: https://doaj.org/article/1201518e80a843888ac0f10a86f7d812

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Akademický článek

The central role of pathology labs in breast cancer precision oncology: a call for action

Autor: Giancarlo Pruneri, Daniele Lorenzini, Mauro G. Mastropasqua, Giuseppe Perrone, Antonio Rizzo, Donatella Santini, Chiara C. Volpi, Saverio Cinieri, Alberto Zambelli, Anna Sapino, Isabella Castellano

Publikováno v: npj Breast Cancer, Vol 9, Iss 1, Pp 1-4 (2023)

Multigenic tests represent an essential tool for the selection of adjuvant therapy in estrogen-positive/HER2-negative (ER + /HER2-) early breast cancer (BC). The workflow of these tests, either if they are externalized or carried out in-house, genera

Externí odkaz: https://doaj.org/article/69dd406149ad42729238c4c9f88b56fd

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Akademický článek

Targeted RNA-sequencing analysis for fusion transcripts detection in tumor diagnostics: assessment of bioinformatic tools reliability in FFPE samples

Publikováno v: Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 5, Pp 582-597 (2022)

Aim: Diagnostic laboratories are progressively introducing next-generation sequencing (NGS) technologies in the routine workflow to meet the increasing clinical need for comprehensive molecular characterization in cancer patients for diagnosis and pr

Externí odkaz: https://doaj.org/article/d74b17c328cc45588837b22f3835282c

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Akademický článek

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Mutant KRAS (KM) is associated with poor prognosis in lung cancer and reported to promote lipid metabolism. Here, the authors show that fatty acid synthesis, which provides lipids to repair oxidized phospholipids through the FASN-Lands cycle axis, is

Externí odkaz: https://doaj.org/article/cecb398260bb4e0d93d08e97a822d9aa

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Akademický článek

A2AR Expression and Immunosuppressive Environment Independent of KRAS and GNAS Mutations in Pseudomyxoma Peritonei

Autor: Shigeki Kusamura, Adele Busico, Elena Conca, Iolanda Capone, Luca Agnelli, Daniele Lorenzini, Silvia Brich, Marta Angelini, Chiara Costanza Volpi, Desirè Viola Trupia, Vincenzo Lagano, Tommaso Torelli, Annunziata Gloghini, Dario Baratti, Marcello Guaglio, Massimo Milione, Marcello Deraco, Federica Perrone

Publikováno v: Biomedicines, Vol 11, Iss 7, p 2049 (2023)

In pseudomyxoma peritonei (PMP), KRAS and GNAS mutations are frequent. We hypothesized that these mutations may contribute to the suppression of antitumor immunity: KRAS may induce GMCSF expression, while GNAS may enhance the expression of cyclic ade

Externí odkaz: https://doaj.org/article/bcdd95d8ae5e422d8150f874928f4e69

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Akademický článek

Osteoclast-like stromal giant cells in breast cancer likely belong to the spectrum of immunosuppressive tumor-associated macrophages

Autor: Elham Sajjadi, Gabriella Gaudioso, Andrea Terrasi, Francesca Boggio, Konstantinos Venetis, Mariia Ivanova, Letizia Bertolasi, Gianluca Lopez, Letterio Runza, Alice Premoli, Daniele Lorenzini, Elena Guerini-Rocco, Stefano Ferrero, Valentina Vaira, Nicola Fusco

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Background: Breast cancer with osteoclast-like stromal giant cells (OSGC) is an exceedingly rare morphological pattern of invasive breast carcinoma. The tumor immune microenvironment (TIME) of these tumors is populated by OSGC, which resemble osteocl

Externí odkaz: https://doaj.org/article/e7b1cfe04bef4417850659524f80aa39

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Akademický článek

Phase II study of durvalumab (anti-PD-L1) and trametinib (MEKi) in microsatellite stable (MSS) metastatic colorectal cancer (mCRC)

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)

Background Monotherapy with immune checkpoint blockade is ineffective for patients (pts) with microsatellite stable (MSS) metastatic colorectal cancer (mCRC). This study investigates whether the combination of trametinib (T) with durvalumab (D) can a

Externí odkaz: https://doaj.org/article/df046ec2d0ff48c99275fc303b6ac56b

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