Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Daniele Fancelli"'
Autor:
Lucia Falbo, Hervé Técher, Vincenzo Sannino, Michela Robusto, Giovanni Fagà, Federica Pezzimenti, Francesco Romeo, Luca Gabriele Colombo, Stefania Vultaggio, Daniele Fancelli, Silvia Monzani, Valentina Cecatiello, Sebastiano Pasqualato, Mario Varasi, Ciro Mercurio, Vincenzo Costanzo
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110567- (2024)
Summary: Replication origin assembly is a pivotal step in chromosomal DNA replication. In this process, the ORC complex binds DNA and, together with the CDC6 and CDT1, promotes the loading of the MCM helicase. Chemicals targeting origin assembly migh
Externí odkaz:
https://doaj.org/article/adb2579a538741ef9e88a77c7a491485
Autor:
Silvia Brambillasca, Maria Rosaria Cera, Adrian Andronache, Sumit Kumar Dey, Giovanni Fagá, Daniele Fancelli, Emanuela Frittoli, Maurizio Pasi, Michela Robusto, Mario Varasi, Giorgio Scita, Ciro Mercurio
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116991- (2024)
Macropinocytosis is a cellular process that enables cells to engulf extracellular material, such as nutrients, growth factors, and even whole cells. It is involved in several physiological functions as well as pathological conditions. In cancer cells
Externí odkaz:
https://doaj.org/article/d5f0a35ef021442c8611f40ec968b42e
Autor:
Francesca Cavallo, Flavia Troglio, Giovanni Fagà, Daniele Fancelli, Reinald Shyti, Sebastiano Trattaro, Matteo Zanella, Giuseppe D’Agostino, James M. Hughes, Maria Rosaria Cera, Maurizio Pasi, Michele Gabriele, Maddalena Lazzarin, Marija Mihailovich, Frank Kooy, Alessandro Rosa, Ciro Mercurio, Mario Varasi, Giuseppe Testa
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-18 (2020)
Abstract Background Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental condition affecting almost 1% of children, and represents a major unmet medical need with no effective drug treatment available. Duplication at 7q11.23 (7Dup)
Externí odkaz:
https://doaj.org/article/8a6215aea7bb40f2bf98c05a3d022f77
Autor:
Jürgen Moll, Daniele Fancelli, Enrico Pesenti, Dario Ballinari, Aurelio Marsiglio, Veronica Patton, Cristina Alli, Chiara Soncini, Claudio Arrigoni, Paola Zugnoni, Paola Storici, Luisa Rusconi, Paola Vianello, Maurizio Rocchetti, Gemma Texido, Anna Degrassi, Valter Croci, Laura Gianellini, Paolo Cappella, Maria Laura Giorgini, Roberta Ceruti, Patrizia Carpinelli
Supplementary Fig. S1 from PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad37abd8e1e506016be814b1b51c632
https://doi.org/10.1158/1535-7163.22483142.v1
https://doi.org/10.1158/1535-7163.22483142.v1
Autor:
Jürgen Moll, Daniele Fancelli, Enrico Pesenti, Dario Ballinari, Aurelio Marsiglio, Veronica Patton, Cristina Alli, Chiara Soncini, Claudio Arrigoni, Paola Zugnoni, Paola Storici, Luisa Rusconi, Paola Vianello, Maurizio Rocchetti, Gemma Texido, Anna Degrassi, Valter Croci, Laura Gianellini, Paolo Cappella, Maria Laura Giorgini, Roberta Ceruti, Patrizia Carpinelli
Supplementary Table S1 from PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c070b33c5aefdf25ed1f037d109f678
https://doi.org/10.1158/1535-7163.22483139.v1
https://doi.org/10.1158/1535-7163.22483139.v1
Autor:
Jürgen Moll, Daniele Fancelli, Enrico Pesenti, Dario Ballinari, Aurelio Marsiglio, Veronica Patton, Cristina Alli, Chiara Soncini, Claudio Arrigoni, Paola Zugnoni, Paola Storici, Luisa Rusconi, Paola Vianello, Maurizio Rocchetti, Gemma Texido, Anna Degrassi, Valter Croci, Laura Gianellini, Paolo Cappella, Maria Laura Giorgini, Roberta Ceruti, Patrizia Carpinelli
PHA-739358 is a small-molecule 3-aminopyrazole derivative with strong activity against Aurora kinases and cross-reactivities with some receptor tyrosine kinases relevant for cancer. PHA-739358 inhibits all Aurora kinase family members and shows a dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb0bde1377ecffa21e6fcbd2a5240d3
https://doi.org/10.1158/1535-7163.c.6531083.v1
https://doi.org/10.1158/1535-7163.c.6531083.v1
Autor:
Jürgen Moll, Antonella Isacchi, Alexander D. Cameron, Patrizia Carpinelli, Daniele Fancelli, Luisa Rusconi, Rosita Lupi, Riccardo Colombo, Pamela Rosettani, Chiara Soncini, Elena Casale, Michele Modugno
Mutations in the kinase domain of Bcr-Abl are the most common cause of resistance to therapy with imatinib in patients with chronic myelogenous leukemia (CML). Second-generation Bcr-Abl inhibitors are able to overcome most imatinib-resistant mutants,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd319d534851153a0e0e679178e5bf0b
https://doi.org/10.1158/0008-5472.c.6496034
https://doi.org/10.1158/0008-5472.c.6496034
Autor:
Jürgen Moll, Antonella Isacchi, Alexander D. Cameron, Patrizia Carpinelli, Daniele Fancelli, Luisa Rusconi, Rosita Lupi, Riccardo Colombo, Pamela Rosettani, Chiara Soncini, Elena Casale, Michele Modugno
Supplementary Table 1 from Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor PHA-739358
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec67113b12c717c73d8943be728656c
https://doi.org/10.1158/0008-5472.22368614.v1
https://doi.org/10.1158/0008-5472.22368614.v1
Autor:
Maria Rosaria Cera, Giuseppe Testa, Reinald Shyti, Daniele Fancelli, Ciro Mercurio, Maurizio Pasi, Marija Mihailovich, Michele Gabriele, Giuseppe D'Agostino, Maddalena Lazzarin, Matteo Zanella, Francesca Cavallo, Sebastiano Trattaro, Flavia Troglio, Alessandro Rosa, R. Frank Kooy, Mario Varasi, Giovanni Fagà, James M Hughes
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-18 (2020)
Molecular Autism
Molecular Autism
Background Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental condition affecting almost 1% of children, and represents a major unmet medical need with no effective drug treatment available. Duplication at 7q11.23 (7Dup), encompa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4915-4925
Almost all invasive cancers, regardless of tissue origin, are characterized by specific modifications of their cellular energy metabolism. In fact, a strong predominance of aerobic glycolysis over oxidative phosphorylation (Warburg effect) is usually