Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Daniele Fachinetti"'
Autor:
Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, Fumihito Miura, Pavel Bashtrykov, Frédéric Bonhomme, Catalina Salinas-Luypaert, Deis Haxholli, Nicole Gutekunst, Bihter Özdemir Aygenli, Laure Ferry, Olivier Kirsh, Marthe Laisné, Andrea Scelfo, Enes Ugur, Paola B. Arimondo, Heinrich Leonhardt, Masato T. Kanemaki, Till Bartke, Daniele Fachinetti, Albert Jeltsch, Takashi Ito, Pierre-Antoine Defossez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA methylation maintenance by DNMT1, or if it has impor
Externí odkaz:
https://doaj.org/article/f127c2781d354cf983fa3decda8e2001
Autor:
Lorenza Garribba, Giuseppina De Feudis, Valentino Martis, Martina Galli, Marie Dumont, Yonatan Eliezer, René Wardenaar, Marica Rosaria Ippolito, Divya Ramalingam Iyer, Andréa E. Tijhuis, Diana C. J. Spierings, Michael Schubert, Silvia Taglietti, Chiara Soriani, Simon Gemble, Renata Basto, Nick Rhind, Floris Foijer, Uri Ben-David, Daniele Fachinetti, Ylli Doksani, Stefano Santaguida
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
Externí odkaz:
https://doaj.org/article/e226f0a659b0484e8d7815070b875a08
Autor:
Stefano Gnan, Joseph M. Josephides, Xia Wu, Manuela Spagnuolo, Dalila Saulebekova, Mylène Bohec, Marie Dumont, Laura G. Baudrin, Daniele Fachinetti, Sylvain Baulande, Chun-Long Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
A scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths.
Externí odkaz:
https://doaj.org/article/fd1aed25b9a042d2a333d9c51e20f10b
Autor:
Riccardo Gamba, Giulia Mazzucco, Therese Wilhelm, Leonid Velikovsky, Catalina Salinas-Luypaert, Florian Chardon, Julien Picotto, Mylène Bohec, Sylvain Baulande, Ylli Doksani, Daniele Fachinetti
Publikováno v:
PLoS Genetics, Vol 18, Iss 7 (2022)
Centromeres are key elements for chromosome segregation. Canonical centromeres are built over long-stretches of tandem repetitive arrays. Despite being quite abundant compared to other loci, centromere sequences overall still represent only 2 to 5% o
Externí odkaz:
https://doaj.org/article/272faa3ba4e54c9fb8d4d6d44646dd6b
Autor:
Daniel Jeffery, Alberto Gatto, Katrina Podsypanina, Charlène Renaud-Pageot, Rebeca Ponce Landete, Lorraine Bonneville, Marie Dumont, Daniele Fachinetti, Geneviève Almouzni
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Jeffery et al. develop a system of inducible and reversible CENP-A overexpression, combined with a switch in p53 status in human cell lines. They find the tumor suppressor p53 as a key determinant of how CENP-A impacts cell state, cell identity and t
Externí odkaz:
https://doaj.org/article/ec3aeda702904a2b82c7ea6a96ce10f4
Autor:
Catalina Salinas-Luypaert, Praveen Kumar Allu, Glennis A. Logsdon, Jennine M. Dawicki-McKenna, Craig W. Gambogi, Daniele Fachinetti, Ben E. Black
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109924- (2021)
Summary: Functional tags are ubiquitous in cell biology, and for studies of one chromosomal locus, the centromere, tags have been remarkably useful. The centromere directs chromosome inheritance at cell division. The location of the centromere is def
Externí odkaz:
https://doaj.org/article/c312cc62e4fe4719a23103d6d0993732
Autor:
Viviana Barra, Glennis A. Logsdon, Andrea Scelfo, Sebastian Hoffmann, Solène Hervé, Aaron Aslanian, Yael Nechemia-Arbely, Don W. Cleveland, Ben E. Black, Daniele Fachinetti
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Phosphorylation of CENP-A on serine 7 has been proposed to control centromere assembly and function. Here, the authors use gene targeting at both endogenous CENP-A alleles and gene replacement in human cells to demonstrate that CENP-A that cannot be
Externí odkaz:
https://doaj.org/article/423a646c0dbd4210bde7daad24002f8e
Autor:
Marie Dumont, Daniele Fachinetti
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 4 (2020)
The overall structure and composition of human centromeres have been well reported, but how these elements vary between individual chromosomes and influence the chromosome-specific behavior during mitosis remains untested. In our study, we discover t
Externí odkaz:
https://doaj.org/article/7455db1fc0324856bd453201dd7f8b5b
Autor:
Lucie Y. Guo, Praveen Kumar Allu, Levani Zandarashvili, Kara L. McKinley, Nikolina Sekulic, Jennine M. Dawicki-McKenna, Daniele Fachinetti, Glennis A. Logsdon, Ryan M. Jamiolkowski, Don W. Cleveland, Iain M. Cheeseman, Ben E. Black
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Centromere maintenance depends on the persistence of the histone variant CENP-A at the centromeres. Here, the authors characterize the core centromeric nucleosome complex wherein CENP-C confers a stable CENP-A nucleosome conformation and CENP-N faste
Externí odkaz:
https://doaj.org/article/007ef2a91d124eb6baa7acd0387157c4
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Centromeres are chromosomal domains epigenetically specified by the presence of the CENP-A containing nucleosomes that control chromosome segregation. Here the authors show that α-amino trimethylation of CENP-A by the enzyme NRMT is required for cen
Externí odkaz:
https://doaj.org/article/f4fd7f8ba942491ca6ad29bb5cdc3151