Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Daniele Casero"'
Autor:
Arturo Galvani, Paola Magnaghi, Enrico Pesenti, Antonella Isacchi, Daniele Donati, Eduard Felder, Gang Li, Jean-Michel Vernier, Jason Harris, Ge Wei, David Anderson, Luca Mologni, Tiziano Bandiera, Paolo Orsini, Daniele Casero, Maria Beatrice Saccardo, Nadia Amboldi, Nilla Avanzi, Anna Degrassi, Gemma Texido, Marina Ciomei, Dario Ballinari, Romana Pulci, Cristina De Ponti, Roberta Bosotti, Patrizia Banfi, Maria Menichincheri, Elena Ardini
Supplementary experimental procedures are described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e7349af36e6ac21496c6964180ab8f
https://doi.org/10.1158/1535-7163.22508037
https://doi.org/10.1158/1535-7163.22508037
Autor:
Arturo Galvani, Paola Magnaghi, Enrico Pesenti, Antonella Isacchi, Daniele Donati, Eduard Felder, Gang Li, Jean-Michel Vernier, Jason Harris, Ge Wei, David Anderson, Luca Mologni, Tiziano Bandiera, Paolo Orsini, Daniele Casero, Maria Beatrice Saccardo, Nadia Amboldi, Nilla Avanzi, Anna Degrassi, Gemma Texido, Marina Ciomei, Dario Ballinari, Romana Pulci, Cristina De Ponti, Roberta Bosotti, Patrizia Banfi, Maria Menichincheri, Elena Ardini
Supplementary Figure 1. Efficacy of entrectinib on KM12 xenograft model using the scheduling 4 days on/ 3 days off. Supplementary Figure 2. Mechanism of action of entrectinib compared to crizotinib in ALK-dependent Ba/F3 cells. Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f11ccf8c2eee09b004c4cb5d12e7089
https://doi.org/10.1158/1535-7163.22508040
https://doi.org/10.1158/1535-7163.22508040
Autor:
Claudia Perrera, Maurizio Pulici, Patrizia Banfi, Nilla Avanzi, Davide Carenzi, Daniele Casero, Antonella Ciavolella, Laura Gianellini, Fabio Gasparri, Grazia Saturno, Barbara Valsasina, Elena Ardini, Alessia Montagnoli, Arturo P. Galvani, Antonella Isacchi
Publikováno v:
Cancer Research. 83:1615-1615
PERK and GCN2 are eIF-2α serine-threonine kinases activated by endoplasmic reticulum (ER) stress and amino acid deprivation respectively. These kinases are key effectors of the unfolded protein response (UPR) and amino acid Response (AAR) branches o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2e69ece3579c0c6aedc740e44219f0b
https://doi.org/10.1158/1538-7445.am2023-1615
https://doi.org/10.1158/1538-7445.am2023-1615
Autor:
Achille Panzeri, G. Canevari, Sabrina Cribioli, Nadia Amboldi, Nilla Avanzi, Paola Gnocchi, Jay Bertrand, Arturo Galvani, Marina Ciomei, Simona Bindi, Eduard R. Felder, Gabriele Fachin, Ilaria Motto, Antonella Isacchi, Daniele Casero, Daniele Donati, Nicoletta Colombo, Maria Gabriella Brasca, Marcella Nesi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:2387-2407
Compound 1, a hit from the screening of our chemical collection displaying activity against JAK2, was deconstructed for SAR analysis into three regions, which were explored. A series of compounds was synthesized leading to the identification of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6a5bcbfb3e197406e730be2c53f92e
https://doi.org/10.1016/j.bmc.2015.03.059
https://doi.org/10.1016/j.bmc.2015.03.059
Autor:
Roberta Ceruti, Arturo Galvani, Gemma Texido Romero, Federico Lussana, Elena Ardini, Antonella Isacchi, Paola Gnocchi, Daniele Casero, Gianmaria Borleri, Nilla Avanzi, Wilma Pastori, Alessandro Rambaldi, Marina Ciomei, Andrea Lombardi Borgia, Laura Gianellini
Publikováno v:
Cancer Research. 79:1324-1324
NMS-P088 is a potent and selective inhibitor of FLT3 and KIT kinases, including variants with both primary as well as secondary resistance mutations, in particular retaining potent activity against residue 691 gatekeeper mutation which still represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26d29fc3a29c40d964c936733c02faef
https://doi.org/10.1158/1538-7445.am2019-1324
https://doi.org/10.1158/1538-7445.am2019-1324
Autor:
Sabrina Cribioli, Rachele Alzani, Antonella Isacchi, M. Ciomei, Daniele Casero, Alessia Montagnoli, Daniele Donati, Arturo Galvani, Nadia Amboldi, A. Lombardi Borgia, Nilla Avanzi, L. Mancini, Wilma Pastori, Elena Ardini, Gemma Texido, M. Montemartini
Publikováno v:
European Journal of Cancer. 69:S127-S128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45d5e213370d6e7c6f96761bab6290d6
https://doi.org/10.1016/s0959-8049(16)32980-x
https://doi.org/10.1016/s0959-8049(16)32980-x
Autor:
Dario Ballinari, Arturo Galvani, Fabio Gasparri, Elena Ardini, Andrea Lombardi Borgia, Daniele Casero, Marina Ciomei, Gemma Texido, Nilla Avanzi, Sabrina Cribioli, Rachele Alzani, Antonella Isacchi, Daniele Donati, Wilma Pastori
Publikováno v:
Cancer Research. 78:805-805
FLT3, KIT and CSF1R are members of the class III receptor tyrosine kinase family, characterized by an autoinhibitory juxtamembrane (JM) domain that docks within the kinase domain to stabilize a catalytically inactive conformation. Activating rearrang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf80bc42373aace8864c96f369ebdf12
https://doi.org/10.1158/1538-7445.am2018-805
https://doi.org/10.1158/1538-7445.am2018-805
Autor:
Jason Harris, Anna Degrassi, Gang Li, Tiziano Bandiera, Arturo Galvani, Ge Wei, David F. Anderson, Marina Ciomei, Cristina De Ponti, Eduard R. Felder, Patrizia Banfi, Daniele Casero, Antonella Isacchi, Jean-Michel Vernier, Daniele Donati, Maria Menichincheri, Paolo Orsini, Gemma Texido, Maria Beatrice Saccardo, Nilla Avanzi, Enrico Pesenti, Dario Ballinari, Nadia Amboldi, Luca Mologni, Paola Magnaghi, Elena Ardini, Romana Pulci, Roberta Bosotti
Publikováno v:
Molecular cancer therapeutics. 15(4)
Activated ALK and ROS1 tyrosine kinases, resulting from chromosomal rearrangements, occur in a subset of non–small cell lung cancers (NSCLC) as well as other tumor types and their oncogenic relevance as actionable targets has been demonstrated by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac44c602f6f84d0d49b8963954ac9d9d
https://pubmed.ncbi.nlm.nih.gov/26939704
https://pubmed.ncbi.nlm.nih.gov/26939704
Autor:
Sabrina Cribioli, Eduard R. Felder, Nadia Amboldi, Laura Mancini, Dario Ballinari, Claudia Perrera, Fabio Gasparri, Daniela Asa, Elena Casale, Elena Ardini, Fulvia Roletto, Marina Fasolini, Stefania Re Depaolini, Davide Carenzi, Marina Ciomei, Daniele Casero, Simona Rizzi, Maurizio Pulici, Patrizia Banfi, Antonella Isacchi, Daniele Donati, Arturo Galvani, Ilaria Motto, Barbara Valsasina, Simona Bindi
Publikováno v:
Cancer Research. 77:5163-5163
PERK (PKR-like endoplasmic reticulum kinase) is a serine-threonine kinase associated to endoplasmic reticulum membrane. Together with ATF6 and IRE1, PERK is a key effector of the Unfolded Protein Response (UPR), a network of signaling pathways that e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::052f4395948a293c2f16ba558b863246
https://doi.org/10.1158/1538-7445.am2017-5163
https://doi.org/10.1158/1538-7445.am2017-5163
Autor:
Nilla Avanzi, Sabrina Cribioli, Paola Gnocchi, Jay Bertrand, Danilo Mirizzi, Daniele Casero, Arturo Galvani, Paola Vianello, Maristella Colombo, Eduard R. Felder, Gabriele Fachin, Achille Panzeri, Lucio Ceriani, G. Canevari, Franco Della Vedova, Dario Ballinari, Cinzia Cristiani, Enrico Pesenti, Marcella Nesi, Tiziano Bandiera, Marina Ciomei, Alessandra Cirla, Maria Gabriella Brasca, Antonella Isacchi, Daniele Donati, Ilaria Motto, Simona Bindi, Marina Fasolini, Davide Carenzi
Publikováno v:
Bioorganicmedicinal chemistry. 22(17)
We report herein the discovery, structure guided design, synthesis and biological evaluation of a novel class of JAK2 inhibitors. Optimization of the series led to the identification of the potent and orally bioavailable JAK2 inhibitor 28 (NMS-P953).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0c075da4c4b914848e8b7a2755d219
https://pubmed.ncbi.nlm.nih.gov/25009002
https://pubmed.ncbi.nlm.nih.gov/25009002