Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Daniele Canzio"'
Publikováno v:
Mol Cell
Summary Despite the critical regulatory function of promoter-proximal pausing, the influence of pausing kinetics on transcriptional control remains an active area of investigation. Here, we present Start-TimeLapse-seq (STL-seq), a method that capture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd2c4d714b33a9223093332f8dd715d
https://doi.org/10.1016/j.molcel.2021.08.019
https://doi.org/10.1016/j.molcel.2021.08.019
Autor:
Giuseppina Cabras, Eleonora Loi, Patrizia Zavattari, Antonella Arcella, Felice Giangaspero, Silvia Giordano, Matteo Canale, Luca Faloppi, Loredana Moi, Pierluigi Cocco, Pina Ziranu, Mario Scartozzi, Giannina Satta, Manuela Badiali, Mariagrazia Zucca, Luigi Zorcolo, Maria Grazia Ennas, Viviana Gismondi, Amedeo Columbano, Angelo Restivo, Isabella Morra, Andrea Casadei-Gardini, Manila Antonelli, Ana Florencia Vega-Benedetti, Sara Erika Bellomo, Liliana Varesco, Marco Puzzoni, Antonio Fadda, Daniele Canzio, Sylvain Blois
Publikováno v:
Clinical Epigenetics
Clinical epigenetics, vol 11, iss 1
Clinical epigenetics, vol 11, iss 1
Background Clustered protocadherins (PCDHs) map in tandem at human chromosome 5q31 and comprise three multi-genes clusters: α-, β- and γ-PCDH. The expression of this cluster consists of a complex mechanism involving DNA hub formation through DNA-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382d6fad6c1ed7e03d5cda64bfd8a475
http://europepmc.org/articles/PMC6617643
http://europepmc.org/articles/PMC6617643
Autor:
Tom Maniatis, Daniele Canzio
Publikováno v:
Curr Opin Neurobiol
The assembly of functional neural circuits in vertebrate organisms requires complex mechanisms of self-recognition and self-avoidance. Neurites (axons and dendrites) from the same neuron recognize and avoid self, but engage in synaptic interactions w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c050d343ca720371f4fdacb8cc9bea33
https://pubmed.ncbi.nlm.nih.gov/31710891
https://pubmed.ncbi.nlm.nih.gov/31710891
Autor:
Cathleen M. Lutz, Esther Kaunga, Paolo Guarnieri, Noam D. Rudnick, Tom Maniatis, Sean O'Keeffe, Junqiang Ye, Daniele Canzio, Valeria Gerbino
Publikováno v:
Neuron. 106:789-805.e5
DNA sequence variants in the TBK1 gene associate with or cause sporadic or familial amyotrophic lateral sclerosis (ALS). Here we show that mice bearing human ALS-associated TBK1 missense loss-of-function mutations, or mice in which the Tbk1 gene is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a293b0a0220149a200884d8671c6739
https://doi.org/10.1016/j.neuron.2020.03.005
https://doi.org/10.1016/j.neuron.2020.03.005
The ability of neurites of individual neurons to distinguish between themselves and neurites from other neurons and to avoid self (self-avoidance) plays a key role in neural circuit assembly in both invertebrates and vertebrates. Similarly, when indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8219777c492d04f1c996bc2abc51591
https://resolver.caltech.edu/CaltechAUTHORS:20181023-111350854
https://resolver.caltech.edu/CaltechAUTHORS:20181023-111350854
Publikováno v:
Nucleic acids research, vol 46, iss 14
Nucleic Acids Research
Nucleic Acids Research
Here, we describe an approach to enrich newly transcribed RNAs from primary mouse neurons using 4-thiouridine (s4U) metabolic labeling and solid phase chemistry. This one-step enrichment procedure captures s4U-RNA by using highly efficient methane th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1ce940d1bc17bfe2c362c265c043db
https://escholarship.org/uc/item/2537s5k7
https://escholarship.org/uc/item/2537s5k7
Autor:
Stavros Lomvardas, Tom Maniatis, Adan Horta, Rachel Duffié, Eliot L. Coffey, Erin E. Duffy, Chiamaka L. Nwakeze, Daniele Canzio, Matthew D. Simon, Sandy M. Rajkumar
SUMMARYStochastic and combinatorial activation of clustered Protocadherin (Pcdh) α, β, and γ gene promoters generates a cell-surface identity code in individual neurons that functions in neural circuit assembly. Here we show that Pcdhα promoter c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fe7ad4f7b64581b1307a63d1fce6a9
https://doi.org/10.1101/360206
https://doi.org/10.1101/360206
Autor:
Rachel Duffié, Eliot L. Coffey, Matthew D. Simon, Stavros Lomvardas, Daniele Canzio, Chiamaka L. Nwakeze, Sandy M. Rajkumar, Adan Horta, Erin E. Duffy, Tom Maniatis
Publikováno v:
SSRN Electronic Journal.
Stochastic and combinatorial activation of clustered Protocadherin (Pcdh) α, β, and γ gene promoters generates a cell-surface identity code in individual neurons that functions in neural circuit assembly. Here we show that Pcdhα promoter choice r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02175bdf2cc38798d1dcfbecae72688
https://doi.org/10.2139/ssrn.3207022
https://doi.org/10.2139/ssrn.3207022
Autor:
Kevin Monahan, Tom Maniatis, Eliot L. Coffey, Adan Horta, Rachel Duffié, Sean O'Keeffe, Matthew D. Simon, Chiamaka L. Nwakeze, Daniele Canzio, Erin E. Duffy, Stavros Lomvardas, Sandy M. Rajkumar
Publikováno v:
Cell, vol 177, iss 3
Summary Stochastic activation of clustered Protocadherin (Pcdh) α, β, and γ genes generates a cell-surface identity code in individual neurons that functions in neural circuit assembly. Here, we show that Pcdhα gene choice involves the activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ceee051feba7e3a5811d32d74f69a4a
https://doi.org/10.1016/j.cell.2019.03.008
https://doi.org/10.1016/j.cell.2019.03.008
Autor:
Adam G. Larson, Edward Pate, Hiten D. Madhani, Jennifer F. Garcia, Geeta J. Narlikar, Shenping Wu, Diana B. Marina, Daniele Canzio, Nariman Naber, Roger Cooke, Maofu Liao, Yifan Cheng, Peter Schuck
Publikováno v:
Nature. 496:377-381
The Schizosaccharomyces pombe HP1 protein, Swi6, is shown to exist in an auto-inhibited state when unbound to chromatin, switching to a spreading-competent state upon binding to the HK9 methyl mark; disrupting this switch affects heterochromatin asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc564dfc6a772abbc2812148b49db99
https://doi.org/10.1038/nature12032
https://doi.org/10.1038/nature12032