Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Daniele Canzani"'
Autor:
Guangfeng Zhou, Domnita-Valeria Rusnac, Hahnbeom Park, Daniele Canzani, Hai Minh Nguyen, Lance Stewart, Matthew F. Bush, Phuong Tran Nguyen, Heike Wulff, Vladimir Yarov-Yarovoy, Ning Zheng, Frank DiMaio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Structure-based virtual screening is a key tool in early drug discovery, with growing interest in the screening of multi-billion chemical compound libraries. However, the success of virtual screening crucially depends on the accuracy of the
Externí odkaz:
https://doaj.org/article/29a1302972a44e30ab683de7520641e9
Publikováno v:
Anal Chem
Human cells make use of hundreds of unique ubiquitin E3 ligases to ensure proteome fidelity and control cellular functions by promoting protein degradation. These processes require exquisite selectivity, but the individual roles of most E3s remain po
Publikováno v:
Journal of Chromatography B. :87-94
Penicillin G has been applied to citrus trees as a potential treatment in the fight against Huanglongbing (HLB). Here, we have developed and validated a method to identify and quantitate penicillin G and two of its metabolites, penillic acid and peni
Autor:
Jo-Marie Cook, Fadi Aldeek, Matthew Standland, Walter Hammack, Ghislain Gerard, Daniele Canzani, Mark R. Crosswhite
Publikováno v:
Journal of AOAC INTERNATIONAL. 100:189-197
Florida citrus depends on a breakthrough in the fight against citrus greening disease. Of the antibiotics used to treatthis disease, penicillin G has been one of the most effective. Because orange fruit grown in the state of Florida are mainly used t
Autor:
Mark R. Crosswhite, Daniele Canzani, Matthew Standland, Fadi Aldeek, Jo Marie Cook, Ghislain Gerard, Walter Hammack
Publikováno v:
Journal of Agricultural and Food Chemistry. 64:6100-6107
In this work, we investigate the stability of penicillin G in various conditions including acidic, alkaline, natural acidic matrices and after treatment of citrus trees that are infected with citrus greening disease. The identification, confirmation,
Autor:
Domniţa-Valeria, Rusnac, Hsiu-Chuan, Lin, Daniele, Canzani, Karena X, Tien, Thomas R, Hinds, Ashley F, Tsue, Matthew F, Bush, Hsueh-Chi S, Yen, Ning, Zheng
Publikováno v:
Molecular cell. 72(5)
Aberrant proteins can be deleterious to cells and are cleared by the ubiquitin-proteasome system. A group of C-end degrons has recently been identified in some of these abnormal polypeptides, which are recognized by specific cullin-RING ubiquitin E3
Publikováno v:
The journal of physical chemistry. A. 122(25)
Ion mobility is emerging as a rapid and sensitive tool for structural characterization. Collision cross-section (Ω) values determined using ion mobility are often compared to values calculated for candidate structures generated through molecular mod
Autor:
Fadi Aldeek, Daniele Canzani
Publikováno v:
Journal of Nutrition and Human Health.
The discovery of penicillin G was one of the most significant findings of the 20th century and certainly one of the most important discoveries in modern medicine. Since the 1940s, the world has remained dependent on this safe and effective antibiotic
Autor:
Daniele Canzani, Thomas R. Hinds, Matthew F. Bush, Hsueh-Chi S. Yen, Ning Zheng, Hsiu-Chuan Lin, Karena X. Tien, Domniţa-Valeria Rusnac, Ashley F. Tsue
Publikováno v:
Molecular Cell. 72:813-822.e4
Aberrant proteins can be deleterious to cells and are cleared by the ubiquitin-proteasome system. A group of C-end degrons that are recognized by specific cullin-RING ubiquitin E3 ligases (CRLs) has recently been identified in some of these abnormal