Effect of the addition of a mental health specialist for evaluation of undiagnosed patients in centres for rare diseases (ZSE-DUO): a prospective, controlled trial with a two-phase cohort designResearch in context

Autor: Helge Hebestreit, Anne-Marie Lapstich, Lilly Brandstetter, Christian Krauth, Jürgen Deckert, Kirsten Haas, Lisa Pfister, Stefanie Witt, Christopher Schippers, Jan Dieris-Hirche, Tim Maisch, Oliver Tüscher, Lavinia Bârlescu, Alexandra Berger, Mark Berneburg, Vanessa Britz, Anna Deibele, Holm Graeßner, Harald Gündel, Gereon Heuft, Thomas Lücke, Christine Mundlos, Julia Quitmann, Frank Rutsch, Katharina Schubert, Jörg Bernhard Schulz, Susann Schweiger, Cornelia Zeidler, Lena Zeltner, Martina de Zwaan, Federica Akkaya, Christine Babka, Lisa Bannert, Anja Bärsch-Michelmann, Leonie Böhm, Folke Brinkmann, Monika Bullinger, Holger Cario, Moritz de Greck, Klaus-Michael Debatin, Katrin Dillmann-Jehn, Jutta Eymann, Julia Frisch, Anja Glode, Vega Gödecke, Corinna Grasemann, Eva Grauer, Astrid Haas, Lea Haisch, Isabell, Heinrich, Melissa Held, Julia Hennermann, Stephan Herpertz, Anne Herrmann-Werner, Julian Hett, Peter Heuschmann, Bettina Hilbig, Laura Holthöfer, Christiane Imhof, Florian Junne, Jan Kassubek, Kevin-Thomas Koschitzki, Heike Krassort, Birgit Kropff, Julia Kuhn, Philipp Latzko, Thomas Loew, Albert C. Ludolph, Torsten Meyer, Isabell Meyer dos Santos, Klaus Mohnike, Martina Monninger, Martin Mücke, Susanne Müller, Thomas Musacchio, Margret Nießen, Mariel Nöhre, Stephan Ott, Andrea Petermann-Meyer, Christina Pfeifer-Duck, Lea-Sophie Piduhn, Carina Rampp, Olaf Rieß, Kristina Schaubert, Annika Schmidt, Simone Schneider, Ludger Schoels, Martina Schwalba, Udo Selig, Alexandra Sroka, Toni Steinbüchel, Sebastian Stösser, Steffi Suchant, Kathrin Ungethüm, Matthias Vogel, Daniela Volk, Christoph Vollmuth, Solange Volnov, Thomas O.F. Wagner, Sabrina Walter, Bodo Warrings, Kamil Zajt, Karola Zenker, David Zhang, Stephan Zipfel, Lavinia Aurelia Bârlescu, Julia Hannah Quitmann, Jörg B. Schulz, Lena Margarete Zeltner

Publikováno v: EClinicalMedicine, Vol 65, Iss , Pp 102260- (2023)

Summary: Background: People with complex symptomatology but unclear diagnosis presenting to a centre for rare diseases (CRD) may present with mental (co-)morbidity. We hypothesised that combining an expert in somatic medicine with a mental health spe

Externí odkaz: https://doaj.org/article/7104fbd316dd40be90da99c4bb8c26c0

Immunoproteomics reveal increased serum IgG3/5 binding to Dermatophagoides and yeast protein antigens in severe equine asthma in a preliminary study

Autor: Christiane L. Schnabel, Maria-Christin Jentsch, Sabrina Lübke, Sarah Kaiser-Thom, Vinzenz Gerber, Susanne Vrtala, Huey-Jy Huang, Claudio Rhyner, Bettina Wagner, Ralf Hoffmann, Daniela Volke

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionSevere equine asthma (SEA) is a common, chronic respiratory disease of horses characterized by hyperreactivity to hay dust which has many similarities to severe neutrophilic asthma in humans. SEA-provoking antigens have not been comprehen

Externí odkaz: https://doaj.org/article/0af7bc85d53a404f88e729deba3dfb84

Sensitive and specific serological ELISA for the detection of SARS-CoV-2 infections

Autor: Ji Luo, Alexandra Brakel, Andor Krizsan, Tobias Ludwig, Marina Mötzing, Daniela Volke, Nicole Lakowa, Thomas Grünewald, Claudia Lehmann, Johannes Wolf, Stephan Borte, Sanja Milkovska-Stamenova, Jörg Gabert, Felix Fingas, Markus Scholz, Ralf Hoffmann

Publikováno v: Virology Journal, Vol 19, Iss 1, Pp 1-10 (2022)

Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered the worldwide coronavirus disease 2019 (COVID-19) pandemic. Serological assays for the detection of SARS-CoV-2 infections are important to understand t

Externí odkaz: https://doaj.org/article/c482d7c47e974f4aac666d738e04448e

Pre-purification of diatom pigment protein complexes provides insight into the heterogeneity of FCP complexes

Autor: Marcel Kansy, Daniela Volke, Line Sturm, Christian Wilhelm, Ralf Hoffmann, Reimund Goss

Publikováno v: BMC Plant Biology, Vol 20, Iss 1, Pp 1-16 (2020)

Abstract Background Although our knowledge about diatom photosynthesis has made huge progress over the last years, many aspects about their photosynthetic apparatus are still enigmatic. According to published data, the spatial organization as well as

Externí odkaz: https://doaj.org/article/b1cab01dbcde4616acfe91c3f741499c

Sensitive and immunogen-specific serological detection of Rodentibacter pneumotropicus infections in mice

Autor: Felix Fingas, Daniela Volke, Rayk Hassert, Juliane Fornefett, Sophie Funk, Christoph Georg Baums, Ralf Hoffmann

Publikováno v: BMC Microbiology, Vol 19, Iss 1, Pp 1-13 (2019)

Abstract Background Rodentibacter (R.) pneumotropicus colonizes the respiratory and urogenital tracts of laboratory mice with a reported moderate serological prevalence from 4 to 13%. Thus, regular tests to identify this pathogen in mice are recommen

Externí odkaz: https://doaj.org/article/35d27e8e947c448595a6038d3de78022