Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Daniela Tosoni"'
Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
Autor:
Giovanni Tosi, Alessandro Paoli, Gaia Zuccolotto, Emilia Turco, Manuela Simonato, Daniela Tosoni, Francesco Tucci, Pietro Lugato, Monica Giomo, Nicola Elvassore, Antonio Rosato, Paola Cogo, Salvatore Pece, Massimo M. Santoro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract CoQ10 (Coenzyme Q10) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ10 is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer
Externí odkaz:
https://doaj.org/article/fcdadd32e3c74c049a3cabd84a68dbf7
Autor:
Marianna Talia, Francesca Cirillo, Asia Spinelli, Azzurra Zicarelli, Domenica Scordamaglia, Lucia Muglia, Salvatore De Rosis, Damiano Cosimo Rigiracciolo, Gianfranco Filippelli, Ida Daniela Perrotta, Mariano Davoli, Rosanna De Rosa, Rachele Macirella, Elvira Brunelli, Anna Maria Miglietta, Bruno Nardo, Daniela Tosoni, Salvatore Pece, Ernestina Marianna De Francesco, Antonino Belfiore, Marcello Maggiolini, Rosamaria Lappano
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-22 (2023)
Abstract Background The receptor for advanced glycation-end products (RAGE) and its ligands have been implicated in obesity and associated inflammatory processes as well as in metabolic alterations like diabetes. In addition, RAGE-mediated signaling
Externí odkaz:
https://doaj.org/article/6d89c71a608343ffada9d5590c9fb661
Autor:
Vincenzo Salemme, Mauro Vedelago, Alessandro Sarcinella, Federico Moietta, Alessio Piccolantonio, Enrico Moiso, Giorgia Centonze, Marta Manco, Andrea Guala, Alessia Lamolinara, Costanza Angelini, Alessandro Morellato, Dora Natalini, Raffaele Calogero, Danny Incarnato, Salvatore Oliviero, Laura Conti, Manuela Iezzi, Daniela Tosoni, Giovanni Bertalot, Stefano Freddi, Francesco A. Tucci, Francesco De Sanctis, Cristina Frusteri, Stefano Ugel, Vincenzo Bronte, Federica Cavallo, Paolo Provero, Marta Gai, Daniela Taverna, Emilia Turco, Salvatore Pece, Paola Defilippi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibition
Externí odkaz:
https://doaj.org/article/6ef08fc8d1c74047923f8519dfa3b883
Autor:
Chiara Di Malta, Angela Zampelli, Letizia Granieri, Claudia Vilardo, Rossella De Cegli, Laura Cinque, Edoardo Nusco, Salvatore Pece, Daniela Tosoni, Francesca Sanguedolce, Nicolina Cristina Sorrentino, Maria J Merino, Deborah Nielsen, Ramaprasad Srinivasan, Mark W Ball, Christopher J Ricketts, Cathy D Vocke, Martin Lang, Baktiar Karim, Luisa Lanfrancone, Laura S Schmidt, W Marston Linehan, Andrea Ballabio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp 1-12 (2023)
Abstract Birt‐Hogg‐Dubé (BHD) syndrome is an inherited familial cancer syndrome characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and cysts and caused by loss‐of‐function pathogenic variants in the gene enc
Externí odkaz:
https://doaj.org/article/fc7292bb504a4e85bf4c9b3aa30dc3e3
Autor:
Irene Schiano Lomoriello, Giovanni Giangreco, Claudia Iavarone, Chiara Tordonato, Giusi Caldieri, Gaetana Serio, Stefano Confalonieri, Stefano Freddi, Fabrizio Bianchi, Stefania Pirroni, Giovanni Bertalot, Giuseppe Viale, Davide Disalvatore, Daniela Tosoni, Maria Grazia Malabarba, Andrea Disanza, Giorgio Scita, Salvatore Pece, Brian K. Pilcher, Manuela Vecchi, Sara Sigismund, Pier Paolo Di Fiore
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a
Externí odkaz:
https://doaj.org/article/13d80ead99db4faeaae47bea7bd4c693
Autor:
Salvatore Pece, Davide Disalvatore, Daniela Tosoni, Manuela Vecchi, Stefano Confalonieri, Giovanni Bertalot, Giuseppe Viale, Marco Colleoni, Paolo Veronesi, Viviana Galimberti, Pier Paolo Di Fiore
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 352-362 (2019)
Background: Breast cancers show variations in the number and biological aggressiveness of cancer stem cells that correlate with their clinico-prognostic and molecular heterogeneity. Thus, prognostic stratification of breast cancers based on cancer st
Externí odkaz:
https://doaj.org/article/b40e7dcb6f9047acbd9737927b3ce038
Autor:
Marco Gaviraghi, Andrea Rabellino, Annapaola Andolfo, Matthias Brand, Chiara Brombin, Paola Bagnato, Giuseppina De Feudis, Andrea Raimondi, Alberta Locatelli, Daniela Tosoni, Davide Mazza, Luca Gianni, Giovanni Tonon, Yosef Yarden, Carlo Tacchetti, Tiziana Daniele
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/ab7f19c4930741bdaab1594e66d2d405
Autor:
Daniela Tosoni, Sarah Pambianco, Blanche Ekalle Soppo, Silvia Zecchini, Giovanni Bertalot, Giancarlo Pruneri, Giuseppe Viale, Pier Paolo Di Fiore, Salvatore Pece
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 5, Pp 655-671 (2017)
Abstract The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course. In the mouse mammary gland, Numb/p53 downregulation leads to aberrant tissue morphogene
Externí odkaz:
https://doaj.org/article/b6120e12cad542d38838cb0229bb36a2
Autor:
Silvia Grasso, Jennifer Chapelle, Vincenzo Salemme, Simona Aramu, Isabella Russo, Nicoletta Vitale, Ludovica Verdun di Cantogno, Katiuscia Dallaglio, Isabella Castellano, Augusto Amici, Giorgia Centonze, Nanaocha Sharma, Serena Lunardi, Sara Cabodi, Federica Cavallo, Alessia Lamolinara, Lorenzo Stramucci, Enrico Moiso, Paolo Provero, Adriana Albini, Anna Sapino, Johan Staaf, Pier Paolo Di Fiore, Giovanni Bertalot, Salvatore Pece, Daniela Tosoni, Stefano Confalonieri, Manuela Iezzi, Paola Di Stefano, Emilia Turco, Paola Defilippi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
p140Cap adaptor proteins interfere with adhesion and growth factor-dependent signalling in cancer cells but the mechanisms are unclear. Here the authors show that p140Cap interferes with ERBB2-dependent activation of Rac GTPase-controlled circuitries
Externí odkaz:
https://doaj.org/article/3f467620764d4f4e9419cd933a8e92a7
Autor:
Silvia Grasso, Jennifer Chapelle, Vincenzo Salemme, Simona Aramu, Isabella Russo, Nicoletta Vitale, Ludovica Verdun di Cantogno, Katiuscia Dallaglio, Isabella Castellano, Augusto Amici, Giorgia Centonze, Nanaocha Sharma, Serena Lunardi, Sara Cabodi, Federica Cavallo, Alessia Lamolinara, Lorenzo Stramucci, Enrico Moiso, Paolo Provero, Adriana Albini, Anna Sapino, Johan Staaf, Pier Paolo Di Fiore, Giovanni Bertalot, Salvatore Pece, Daniela Tosoni, Stefano Confalonieri, Manuela Iezzi, Paola Di Stefano, Emilia Turco, Paola Defilippi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 14797 (2017); Published online 16 March 2017; Updated 30 March 2018 In the original version of this Article, the affiliation details for Anna Sapino were incorrectly given as Department of Medical Sciences, Un
Externí odkaz:
https://doaj.org/article/eaf0a235a24b45248601d79d48d435f3