Lack of XPC leads to a shift between respiratory complexes I and II but sensitizes cells to mitochondrial stress

Autor: Mateus P. Mori, Rute A. P. Costa, Daniela T. Soltys, Thiago de S. Freire, Franco A. Rossato, Ignácio Amigo, Alicia J. Kowaltowski, Aníbal E. Vercesi, Nadja C. de Souza-Pinto

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract Genomic instability drives tumorigenesis and DNA repair defects are associated with elevated cancer. Metabolic alterations are also observed during tumorigenesis, although a causal relationship between these has not been clearly established.

Externí odkaz: https://doaj.org/article/8c3abd91e76c4e26a1355a84576051ac

The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation.

Autor: Felipe C Beckedorff, Ana C Ayupe, Renan Crocci-Souza, Murilo S Amaral, Helder I Nakaya, Daniela T Soltys, Carlos F M Menck, Eduardo M Reis, Sergio Verjovski-Almeida

Publikováno v: PLoS Genetics, Vol 9, Iss 8, p e1003705 (2013)

The down-regulation of the tumor-suppressor gene RASSF1A has been shown to increase cell proliferation in several tumors. RASSF1A expression is regulated through epigenetic events involving the polycomb repressive complex 2 (PRC2); however, the molec

Externí odkaz: https://doaj.org/article/ec6e8151289d4678a4989b51ca3aa8c0

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells

Autor: Ligia Pereira Castro, Vanesa Gottifredi, Alain Sarasin, Alexandre T. Vessoni, Guilherme Francisco, Silvina Odete Bustos, Annabel Quinet, Daniela T. Soltys, Roger Chammas, Taynah I.P. David, Leticia K. Lerner, Bryan E. Strauss, Carlos Frederico Martins Menck, Anne Stary, Clarissa Ribeiro Reily Rocha

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (3), pp.1270-1280. ⟨10.1093/nar/gkw1196⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of repl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c632e78bf42211a64ddaf21fcf039d4

Análise da natureza genotípica de pacientes Xeroderma pigmentosum brasileiros

Autor: Daniela T. Soltys

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

O NER é uma via de reparo de DNA capaz de lidar com uma ampla variedade de lesões. Participam do NER diversas proteínas, entre elas a endonuclease XPG. Pacientes que possuem mutações no gene XPG apresentam a síndrome XP, e em alguns casos XP/CS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0aa6f75c3ab6d7d656cfc5d846eec9
https://doi.org/10.11606/t.42.2010.tde-05082010-114429

The Intronic Long Noncoding RNA ANRASSF1 Recruits PRC2 to the RASSF1A Promoter, Reducing the Expression of RASSF1A and Increasing Cell Proliferation

Autor: Murilo S. Amaral, Daniela T. Soltys, Felipe Beckedorff, Renan Crocci-Souza, Eduardo M. Reis, Carlos Frederico Martins Menck, Helder I. Nakaya, Ana C. Ayupe, Sergio Verjovski-Almeida

Publikováno v: PLoS Genetics
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Genetics, Vol 9, Iss 8, p e1003705 (2013)

The down-regulation of the tumor-suppressor gene RASSF1A has been shown to increase cell proliferation in several tumors. RASSF1A expression is regulated through epigenetic events involving the polycomb repressive complex 2 (PRC2); however, the molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38afaab0c8dc6903a2e6f161d2e9e793
http://europepmc.org/articles/PMC3749938