Výsledky vyhledávání - "Daniela Struck"

Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

Publikováno v: The Journal of Experimental Medicine

Peroral infection with Toxoplasma gondii leads to the development of small intestinal inflammation dependent on Th1 cytokines. The role of Th17 cells in ileitis is unknown. We report interleukin (IL)-23–mediated gelatinase A (matrixmetalloproteinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9146e35e667c7ce76f4157999103520f
https://doi.org/10.1084/jem.20090900

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IFN Consensus Sequence Binding Protein (Icsbp) Is Critical for Eosinophil Development

Autor: Daniela Struck, Grzegorz Terszowski, Oliver Liesenfeld, Dirk Carstanjen, Maja Milanovic

Publikováno v: The Journal of Immunology. 181:5045-5053

IFN consensus sequence binding protein (Icsbp) (IFN response factor-8) is a hematopoietic transcription factor with dual functions in myelopoiesis and immunity. In this study, we report a novel role of Icsbp in regulating the development of eosinophi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805a4fe87a7410c9ece76a00c0a3a49e
https://doi.org/10.4049/jimmunol.181.7.5045

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Gram-Negative Bacteria Aggravate Murine Small Intestinal Th1-Type Immunopathology following Oral Infection with Toxoplasma gondii

Autor: Ralf R. Schumann, David Fuchs, Dorothee Maria Gescher, Ildiko R. Dunay, Hannah-Katharina Jahn, Ulf B. Göbel, André Fischer, Julia Niebergall, Daniela Struck, Markus M. Heimesaat, Stefan Bereswill, Annette Moter, Oliver Liesenfeld

Publikováno v: The Journal of Immunology. 177:8785-8795

Oral infection of susceptible mice with Toxoplasma gondii results in Th1-type immunopathology in the ileum. We investigated gut flora changes during ileitis and determined contributions of gut bacteria to intestinal inflammation. Analysis of the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da069186409b88c63ad3e7edaa7bbef
https://doi.org/10.4049/jimmunol.177.12.8785

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Treatment with interleukin-18 binding protein ameliorates Toxoplasma gondii-induced small intestinal pathology that is induced by bone marrow cell-derived interleukin-18

Autor: U. Steinhoff, S. Enders, Markus M. Heimesaat, Daniela Struck, A. Stallmach, Oliver Liesenfeld, C. Schmidt, I. Frank

Peroral infection with Toxoplasma gondii results in a Th1-type immunopathology characterized by small intestinal necrosis and is dependent on IL-18. In the present study, we investigated whether treatment with IL-18 binding protein (IL-18bp) prevents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d9d9d63013309732311ae616afcde6
https://europepmc.org/articles/PMC3962761/

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CD2 deficiency partially prevents small bowel inflammation and improves parasite control in murine Toxoplasma gondii infection

Autor: Anja A. Kühl, Jörg C. Hoffmann, Oliver Liesenfeld, Daniela Struck, Katja Grollich, Martin Zeitz, Nina N. Pawlowski

Publikováno v: World journal of gastroenterology. 13(31)

To investigate whether bowel inflammation and/or parasite control is altered in the absence of the T cell adhesion molecule CD2.Wildtype (WT) and CD2 deficient (CD2(-/-)) mice were infected with 100 cysts of Toxoplasma gondii (T. gondii) (ME49) by ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a54ef58d3ef7eba5baf6386e290341
https://pubmed.ncbi.nlm.nih.gov/17696249

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Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control

Autor: Oliver Liesenfeld, Shizuo Akira, Tobias Went, Daniela Struck, Gottfried Alber, Klaus Pfeffer, Anna Vossenkämper, Irmgard Förster, Matthias Lochner, Kioyshi Takeda, Cosme Alvarado-Esquivel

Publikováno v: European journal of immunology. 34(11)

Oral infection of C57BL/6 mice with Toxoplasma gondii results in small intestinal Th1-type immunopathology mediated by local production of IFN-gamma, TNF-alpha, and NO. To analyze whether the proinflammatory cytokines IL-12 and IL-18 play a role in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73ad150a80c95a2e4f705c5c825e961
https://pubmed.ncbi.nlm.nih.gov/15368276

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The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis

Autor: Luisa Möhle, Ulf B. Göbel, Daniela Struck, André Fischer, Oliver Liesenfeld, Anja A. Kühl, Ildiko Rita Dunay, Markus M. Heimesaat, Stefan Bereswill, Marie E. Alutis

Publikováno v: Gut Pathogens

Background Following peroral Toxoplasma (T.) gondii infection, susceptible mice develop acute ileitis due to a microbiota-dependent Th1 type immunopathology. Toll-like-receptor (TLR)-9 is known to recognize bacterial DNA and mediates intestinal infla

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