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of 26
pro vyhledávání: '"Daniela Strobbe"'
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
Autor:
Anthea Di Rita, Angelo Peschiaroli, Pasquale D′Acunzo, Daniela Strobbe, Zehan Hu, Jens Gruber, Mads Nygaard, Matteo Lambrughi, Gerry Melino, Elena Papaleo, Jörn Dengjel, Said El Alaoui, Michelangelo Campanella, Volker Dötsch, Vladimir V. Rogov, Flavie Strappazzon, Francesco Cecconi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Mitophagy is crucial for mitochondrial quality control and maintenance of cellular homeostasis. Here the authors identify an E3 ubiquitin ligase, HUWE1, that collaborates with LC3-interacting protein AMBRA1 to induce mitochondrial clearance.
Externí odkaz:
https://doaj.org/article/ef54c1bc371f46c7a0abb9f445a40480
Autor:
Daniela Strobbe, Leonardo Caporali, Luisa Iommarini, Alessandra Maresca, Monica Montopoli, Andrea Martinuzzi, Alessandro Achilli, Anna Olivieri, Antonio Torroni, Valerio Carelli, Anna Ghelli
Publikováno v:
Neurobiology of Disease, Vol 114, Iss , Pp 129-139 (2018)
There is growing evidence that the sequence variation of mitochondrial DNA (mtDNA), which clusters in population- and/or geographic-specific haplogroups, may result in functional effects that, in turn, become relevant in disease predisposition or pro
Externí odkaz:
https://doaj.org/article/74a86fe31c9448708bfdbbc605ee1c3d
Autor:
Daniela Strobbe, Alexis A. Robinson, Kirsten Harvey, Lara Rossi, Caterina Ferraina, Valerio de Biase, Carlo Rodolfo, Robert J. Harvey, Michelangelo Campanella
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological
Externí odkaz:
https://doaj.org/article/4308247fda784903b4996d500ab6aa1a
Autor:
Leonardo Caporali, Monica Moresco, Fabio Pizza, Chiara La Morgia, Claudio Fiorini, Daniela Strobbe, Corrado Zenesini, Baharak Hooshiar Kashani, Antonio Torroni, Uberto Pagotto, Valerio Carelli, Giuseppe Plazzi
Publikováno v:
Mitochondrion. 63:37-42
Narcolepsy type 1 (NT1) is due to selective loss of hypocretin (hcrt)-producing-neurons. Hcrt is a neuropeptide regulating the sleep/wake cycle, as well as feeding behavior. A subset of NT1 patients become overweight/obese, with a dysmetabolic phenot
Publikováno v:
British Journal of Pharmacology
Pyroptosis is a specialized form of inflammatory cell death which aids the defensive response against invading pathogens. Its normally tight regulation is lost during infection by the severe acute respiratory coronavirus 2 (SARS-CoV-2), and thus, unc
Autor:
Rosella Abeti, Michele Frison, Dong Xia, Kenneth Smith, Lisa Wells, Daniela Strobbe, Federico Turkheimer, Danilo Faccenda, Paola Giunti, Marija Sajic, Manuel Rigon, Michelangelo Campanella, Katy Barnes, Heather Mortiboys, Mona Sadeghian, Britannie S. England-Rendon, Diana Cash
Publikováno v:
Molecular Psychiatry
Dysfunctional mitochondria characterise Parkinson’s Disease (PD). Uncovering etiological molecules, which harm the homeostasis of mitochondria in response to pathological cues, is therefore pivotal to inform early diagnosis and therapy in the condi
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
Autor:
Jens Gruber, Volker Dötsch, Anthea Di Rita, Daniela Strobbe, Michelangelo Campanella, Said El Alaoui, Jörn Dengjel, Flavie Strappazzon, Mads Nygaard, Francesco Cecconi, Elena Papaleo, Pasquale Dâ²Acunzo, Zehan Hu, Angelo Peschiaroli, Gerry Melino, Vladimir V. Rogov, Matteo Lambrughi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Nature Communications
Nature communications 9 (2018). doi:10.1038/s41467-018-05722-3
info:cnr-pdr/source/autori:Di Rita A.; Peschiaroli A.; D'Acunzo P.; Strobbe D.; Hu Z.; Gruber J.; Nygaard M.; Lambrughi M.; Melino G.; Papaleo E.; Dengjel J.; El Alaoui S.; Campanella M.; Dotsch V.; Rogov V.V.; Strappazzon F.; Cecconi F./titolo:HUWE1 E3 ligase promotes PINK1%2FPARKIN-independent mitophagy by regulating AMBRA1 activation via IKK?/doi:10.1038%2Fs41467-018-05722-3/rivista:Nature communications/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Nature Communications
Nature communications 9 (2018). doi:10.1038/s41467-018-05722-3
info:cnr-pdr/source/autori:Di Rita A.; Peschiaroli A.; D'Acunzo P.; Strobbe D.; Hu Z.; Gruber J.; Nygaard M.; Lambrughi M.; Melino G.; Papaleo E.; Dengjel J.; El Alaoui S.; Campanella M.; Dotsch V.; Rogov V.V.; Strappazzon F.; Cecconi F./titolo:HUWE1 E3 ligase promotes PINK1%2FPARKIN-independent mitophagy by regulating AMBRA1 activation via IKK?/doi:10.1038%2Fs41467-018-05722-3/rivista:Nature communications/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 reg
Publikováno v:
Cellular and molecular life sciences : CMLS. 78(8)
Preservation of mitochondrial quality is paramount for cellular homeostasis. The integrity of mitochondria is guarded by the balanced interplay between anabolic and catabolic mechanisms. The removal of bio-energetically flawed mitochondria is mediate
Autor:
Antonella Minutolo, Christine M. M. Hendriks, Rosalba Pecorari, Danilo Faccenda, Daniela Strobbe, Oriana Conte, Stefan Wiezorek, Rosella Abeti, Carsten Bolm, Michelangelo Campanella, Carla Montesano
Publikováno v:
British Journal of Pharmacology
British journal of pharmacology 178(2), 298-311 (2021). doi:10.1111/bph.15279
British journal of pharmacology 178(2), 298-311 (2021). doi:10.1111/bph.15279
British journal of pharmacology 178(2), 298-311 (2021). doi:10.1111/bph.15279
Published by Wiley, Malden, MA
Published by Wiley, Malden, MA
Autor:
Daniela, Strobbe, Rosalba, Pecorari, Oriana, Conte, Antonella, Minutolo, Christine M M, Hendriks, Stefan, Wiezorek, Danilo, Faccenda, Rosella, Abeti, Carla, Montesano, Carsten, Bolm, Michelangelo, Campanella
Publikováno v:
British journal of pharmacology. 178(2)
The mitochondrial FThe chemical structure of the FNHS selectively blocks the consumption of ATP by mitochondria leading a subtle cytotoxicity associated via the concomitant engagement of autophagy which impairs cell viability. NHS achieves such a fun