Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daniela Stanga"'
Autor:
Jean Pierre Bikorimana, Nehme El-Hachem, Jamilah Abusarah, Marina Pereira Gonçalves, Roudy Farah, Gabrielle A. Mandl, Sebastien Talbot, Simon Beaudoin, Daniela Stanga, Sebastien Plouffe, Moutih Rafei
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background The Accum® platform was initially designed to accumulate biomedicines in target cells by inducing endosomal-to-cytosol escape. Interestingly however, the use of unconjugated Accum® was observed to trigger cell death in a variety
Externí odkaz:
https://doaj.org/article/7d2f9cdb541d4c5a89829e139a5119e2
Autor:
Marina Pereira Gonçalves, Roudy Farah, Jean-Pierre Bikorimana, Jamilah Abusarah, Nehme EL-Hachem, Wael Saad, Sebastien Talbot, Daniela Stanga, Simon Beaudoin, Sebastien Plouffe, Moutih Rafei
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109248- (2024)
Summary: Mesenchymal stromal cells (MSCs) have been modified via genetic or pharmacological engineering into potent antigen-presenting cells-like capable of priming responding CD8 T cells. In this study, our screening of a variant library of Accum mo
Externí odkaz:
https://doaj.org/article/e7f19ff8e92643ef933a5d7182a252ff
Autor:
Katherine Stewart, Yaned Gaitan, Maxwell E R Shafer, Lamine Aoudjit, Di Hu, Richa Sharma, Mathieu Tremblay, Hidetaka Ishii, Michael Marcotte, Daniela Stanga, You Chi Tang, Sami Kamel Boualia, Alana H T Nguyen, Tomoko Takano, Nathalie Lamarche-Vane, Silvia Vidal, Maxime Bouchard
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005785 (2016)
Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is provided by GTPase-activating proteins (GAPs), including p190A, that promote the intrinsic GTPase activity of Rho proteins
Externí odkaz:
https://doaj.org/article/0eda3a3522f8409a988741c49533c6d0
Autor:
Rakhilya Murtazina, Alper Gezdirici, Jaya Punetha, Jennifer E. Posey, Davut Pehlivan, Michael Sacher, Mary J H Willis, Nava Segev, Tadahiro Mitani, Jawid M Fatih, Jayne Antony, Yiran Guo, Chris Troedson, Zhanna Lipatova, Valeriya Gyurkovska, Nicole J Van Bergen, James R. Lupski, Felicity Collins, John Christodoulou, Noraldin Al-Deri, Pengfei Liu, Shalini N. Jhangiani, Patrick M. A. Sleiman, Jill V. Hunter, Daniela Stanga, Hakon Hakonarson, Thisara G Ranasinghe, Sean Massey, Ender Karaca, Sarah Zhao, Zeynep Coban Akdemir, Jill A. Rosenfeld, Richard A. Gibbs
Publikováno v:
Brain
The conserved transport protein particle (TRAPP) complexes regulate key trafficking events and are required for autophagy. TRAPPC4, like its yeast Trs23 orthologue, is a core component of the TRAPP complexes and one of the essential subunits for guan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f0055a8a68fb5dea74c74d764561a8
https://europepmc.org/articles/PMC6935753/
https://europepmc.org/articles/PMC6935753/
Autor:
Daniela Stanga, Nava Segev, John Christodoulou, Nicole J Van Bergen, Zhanna Lipatova, Michael Sacher
Publikováno v:
Autophagy
The modular complex TRAPP acts as an activator of a subgroup of Ypt/RAB GTPases. The substrate GTPases and TRAPP are conserved from yeast to human cells, required for secretion and macroautophagy/autophagy and implicated in human disease. All TRAPP c
Autor:
Miroslav P. Milev, Djenann Saint-Dic, Michael Sacher, Daniela Stanga, Cecilia Jimenez-Mallebrera, Qingchuan Zhao
Publikováno v:
Traffic (Copenhagen, Denmark). 20(5)
TRAPPC11 has been implicated in membrane traffic and lipid-linked oligosaccharide synthesis, and mutations in TRAPPC11 result in neuromuscular and developmental phenotypes. Here, we show that TRAPPC11 has a role upstream of autophagosome formation du
Autor:
Carmen Badosa, Anne Schänzer, Michael Sacher, Ana Töpf, Lidia Gonzalez-Quereda, Cristina Jou, Jaume Colomer, Desiré González Barrios, Andreas Hahn, Miroslav P. Milev, Andrés Nascimento, Volker Straub, Katherine Johnson, Cecilia Jimenez-Mallebrera, Pia Gallano, Daniel Natera-de Benito, Carlos Ortez, Djenann Saint-Dic, Daniela Stanga
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports
Scientific Reports
TRAPPC11 was identified as a component of the TRAPP III complex that functions in membrane trafficking and autophagy. Variants in TRAPPC11 have been reported to be associated with a broad spectrum of phenotypes but all affected individuals display mu
Autor:
Charles DeRossi, Daniela Stanga, Dhara Kadakia, Mark A. Lehrman, Ruhina Rafiq, Ningguo Gao, Shikha Nayar, Ana M. Vacaru, Dru Imrie, Hudson H. Freeze, Michael Sacher, Kirsten C. Sadler, Anastasia Baryshnikova, Ayca Cinaroglu, Miroslav P. Milev, Jaime Chu
Publikováno v:
Molecular Biology of the Cell
The trappc11 mutation in zebrafish causes a stressed UPR, leading to fatty liver disease. This phenotype is not due to a trafficking defect but instead results from N-glycosylation defects. Hypoglycosylation and lipid accumulation are also found in p
Autor:
Miroslav P, Milev, Claudio, Graziano, Daniela, Karall, Willemijn F E, Kuper, Noraldin, Al-Deri, Duccio Maria, Cordelli, Tobias B, Haack, Katharina, Danhauser, Arcangela, Iuso, Flavia, Palombo, Tommaso, Pippucci, Holger, Prokisch, Djenann, Saint-Dic, Marco, Seri, Daniela, Stanga, Giovanna, Cenacchi, Koen L I, van Gassen, Johannes, Zschocke, Christine, Fauth, Johannes A, Mayr, Michael, Sacher, Peter M, van Hasselt
Publikováno v:
Journal of medical genetics. 55(11)
The combination of febrile illness-induced encephalopathy and rhabdomyolysis has thus far only been described in disorders that affect cellular energy status. In the absence of specific metabolic abnormalities, diagnosis can be challenging.The object