Výsledky vyhledávání - "Daniela Sommer"

Akademický článek

Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury

Autor: Jana Van Broeckhoven, Céline Erens, Daniela Sommer, Elle Scheijen, Selien Sanchez, Pia M. Vidal, Dearbhaile Dooley, Elise Van Breedam, Alessandra Quarta, Peter Ponsaerts, Sven Hendrix, Stefanie Lemmens

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)

Abstract Background Spinal cord injury (SCI) elicits a robust neuroinflammatory reaction which, in turn, exacerbates the initial mechanical damage. Pivotal players orchestrating this response are macrophages (Mφs) and microglia. After SCI, the infla

Externí odkaz: https://doaj.org/article/f0427bff6b854ed18b3bdea93717bfc4

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Akademický článek

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

Autor: Elien Wouters, Nienke M. de Wit, Jasmine Vanmol, Susanne M. A. van der Pol, Bert van het Hof, Daniela Sommer, Melanie Loix, Dirk Geerts, Jan Ake Gustafsson, Knut R. Steffensen, Tim Vanmierlo, Jeroen F. J. Bogie, Jerome J. A. Hendriks, Helga E. de Vries

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Dysfunction of the blood-brain barrier (BBB) contributes significantly to the pathogenesis of several neuroinflammatory diseases, including multiple sclerosis (MS). Potential players that regulate BBB function are the liver X receptors (LXRs), which

Externí odkaz: https://doaj.org/article/56fc8933ec1142a69ee5c39bf8b09233

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Macrophage phagocytosis after spinal cord injury: when friends become foes

Autor: Aimée J P M Franssen, Dearbhaile Dooley, Jana Van Broeckhoven, Daniela Sommer, Sven Hendrix

Publikováno v: Brain : a journal of neurology. 144(10)

After spinal cord injury, macrophages can exert either beneficial or detrimental effects depending on their phenotype. Aside from their critical role in inflammatory responses, macrophages are also specialized in the recognition, engulfment, and degr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbafe3daaef31e4ceebb3419f4b1d82f
https://pubmed.ncbi.nlm.nih.gov/34244729

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HDAC3 Inhibition Promotes Alternative Activation of Macrophages but Does Not Affect Functional Recovery after Spinal Cord Injury

Autor: Stefanie Lemmens, Daniela Sommer, Paulien Baeten, Sven Hendrix, Selien Sanchez, Myriam Gou Fabregas, Dearbhaile Dooley

Publikováno v: Experimental Neurobiology

After spinal cord injury (SCI), monocyte derived macrophages play a detrimental role. Histone deacetylases (HDACs) are central epigenetic regulators of macrophage-polarization. We hypothesized that HDAC3 inhibition suppresses the pro-inflammatory mac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a180a3f4a60d027e9c980d833585952
http://europepmc.org/articles/PMC6221838

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ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury

Autor: Daniela Sommer, Inge Corstjens, Sven Hendrix, Stefanie Lemmens, Stefan Rose-John, Jana Van Broeckhoven, Pia M. Vidal, Selien Sanchez, Myriam Gou-Fabregas, Jeroen F. J. Bogie, Tim Vanmierlo, Dearbhaile Dooley

Publikováno v: Brain Behavior and Immunity, 80, 129-145. Elsevier Science

A disintegrin and metalloproteinase 17 (ADAM17) is the major sheddase involved in the cleavage of a plethora of cytokines, cytokine receptors and growth factors, thereby playing a substantial role in inflammatory and regenerative processes after cent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fedfb4e500328da17ff8fadb665989
http://hdl.handle.net/1942/29076

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LIM-Only Protein FHL2 Is a Positive Regulator of Liver X Receptors in Smooth Muscle Cells Involved in Lipid Homeostasis

Autor: Milka Sokolović, Carlie J.M. de Vries, Claudia M. van Tiel, Noam Zelcer, Kondababu Kurakula, Pieter B. van Loenen, Duco S. Koenis, Perry D. Moerland, Daniela Sommer, Saskia Scheij

Publikováno v: Kurakula, K, Sommer, D, Sokolovic, M, Moerland, P D, Scheij, S, van Loenen, P B, Koenis, D S, Zelcer, N, van Tiel, C M & de Vries, C J M 2015, ' LIM-only protein FHL2 is a positive regulator of liver X receptors in smooth muscle cells involved in lipid homeostasis ', Molecular and Cellular Biology, vol. 35, no. 1, pp. 52-62 . https://doi.org/10.1128/MCB.00525-14
Molecular and cellular biology, 35(1), 52-62. American Society for Microbiology
Molecular and Cellular Biology, 35(1), 52-62

The LIM-only protein FHL2 is expressed in smooth muscle cells (SMCs) and inhibits SMC-rich-lesion formation. To further elucidate the role of FHL2 in SMCs, we compared the transcriptomes of SMCs derived from wild-type (WT) and FHL2 knockout (KO) mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5ed6093e6aeca44d014043f9245b80
https://doi.org/10.1128/mcb.00525-14

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ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report

Autor: Piet Borst, Astrid S Plomp, Flóra Szeri, Daniela Sommer, Ronald P.J. Oude Elferink, Robert S. Jansen, Sunny Mahakena, András Váradi, Suzanne Duijst, Arthur A.B. Bergen, Koen van de Wetering

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology, 34(9), 1985-9. Lippincott Williams & Wilkins
Arteriosclerosis, thrombosis, and vascular biology, 34(9), 1985-1989. Lippincott Williams and Wilkins

Objective— Mutations in ABCC6 underlie the ectopic mineralization disorder pseudoxanthoma elasticum (PXE) and some forms of generalized arterial calcification of infancy, both of which affect the cardiovascular system. Using cultured cells, we rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff880855474df567d15603d22b5c717
https://hdl.handle.net/20.500.11755/2d7f7b1e-d3f7-4833-b63a-a4f4da50137c

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The Practice of Professional Doctorates: The Case of a UK-Based Distance DBA

Autor: Colin Simpson, Daniela Sommer

In light of the prominent role of socio-materiality in contemporary social scientific (Nicolini, 2012), and particularly educational (Fenwick, Edwards & Sawchuck, 2011) research, this paper uses two practice-based theories to investigate the experien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6e5e830f470beffaa47c86c5395116

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5% Lidocaine Medicated Plaster for the Treatment of Postherpetic Neuralgia: A Review of the Clinical Safety and Tolerability

Autor: Marie Louise Navez, Claire Delorme, Christopher Monella, Irmgard Bösl, Daniela Sommer

Publikováno v: Pain and Therapy

Postherpetic neuralgia (PHN) is a common, very painful, and often long-lasting complication of herpes zoster which is frequently underdiagnosed and undertreated. It mainly affects the elderly, many of whom are already treated for comorbidities with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227d80ebe1bdf2d35b0f831a92fdb4e8

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