Zobrazeno 1 - 10 of 80 pro vyhledávání: '"Daniela Schilling"'
1
Akademický článek
In-vivo X-ray dark-field computed tomography for the detection of radiation-induced lung damage in mice
Autor: Rico Burkhardt, Thomas Gora, Alexander A. Fingerle, Andreas P. Sauter, Felix Meurer, Florian T. Gassert, Sophie Dobiasch, Daniela Schilling, Annette Feuchtinger, Axel K. Walch, Gabriele Multhoff, Julia Herzen, Peter B. Noël, Ernst J. Rummeny, Stephanie E. Combs, Thomas E. Schmid, Franz Pfeiffer, Jan J. Wilkens
Publikováno v: Physics and Imaging in Radiation Oncology, Vol 20, Iss , Pp 11-16 (2021)
Background and Purpose: Radiotherapy of thoracic tumours can lead to side effects in the lung, which may benefit from early diagnosis. We investigated the potential of X-ray dark-field computed tomography by a proof-of-principle murine study in a cli
Externí odkaz: https://doaj.org/article/c4e136775c6a440cb16e1a91eb7e3ace
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3
Akademický článek
Cytosolic Hsp70 as a biomarker to predict clinical outcome in patients with glioblastoma.
Autor: Friederike Lämmer, Claire Delbridge, Silvia Würstle, Frauke Neff, Bernhard Meyer, Jürgen Schlegel, Kerstin A Kessel, Thomas E Schmid, Daniela Schilling, Stephanie E Combs
Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0221502 (2019)
IntroductionThe major stress-inducible heat shock protein 70 (Hsp70) is induced after different stress stimuli. In tumors, elevated intracellular Hsp70 levels were associated on the one hand with radio- and chemotherapy resistance and on the other ha
Externí odkaz: https://doaj.org/article/3b85f7c5e0904aeab3980d599d68b82e
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4
Akademický článek
Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922
Autor: Annett Kühnel, Daniela Schilling, Stephanie E. Combs, Bernhard Haller, Melissa Schwab, Gabriele Multhoff
Publikováno v: Cells, Vol 8, Iss 10, p 1166 (2019)
The inhibition of heat shock protein 90 (Hsp90) a molecular chaperone for multiple oncogenic client proteins is considered as a promising approach to overcome radioresistance. Since most Hsp90 inhibitors activate HSF-1 that induces the transcription
Externí odkaz: https://doaj.org/article/a46d48aa413f476e82f88d960c9af4a8
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5
Akademický článek
Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells.
Autor: Anja Honegger, Daniela Schilling, Sandra Bastian, Jasmin Sponagel, Vladimir Kuryshev, Holger Sültmann, Martin Scheffner, Karin Hoppe-Seyler, Felix Hoppe-Seyler
Publikováno v: PLoS Pathogens, Vol 11, Iss 3, p e1004712 (2015)
Specific types of human papillomaviruses (HPVs) cause cervical cancer. Cervical cancers exhibit aberrant cellular microRNA (miRNA) expression patterns. By genome-wide analyses, we investigate whether the intracellular and exosomal miRNA compositions
Externí odkaz: https://doaj.org/article/f648690e2b8b46809671dbf3ed7de015
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6
Akademický článek
Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1α.
Autor: Daniela Schilling, Christine Bayer, Wei Li, Michael Molls, Peter Vaupel, Gabriele Multhoff
Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31110 (2012)
Ionizing irradiation is a commonly accepted treatment modality for lung cancer patients. However, the clinical outcome is hampered by normal tissue toxicity and tumor hypoxia. Since tumors often have higher levels of active heat shock protein 90 (Hsp
Externí odkaz: https://doaj.org/article/a92976f874f44b8b99bacd5c4810a3c2
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