CETP Expression in Bone-Marrow-Derived Cells Reduces the Inflammatory Features of Atherosclerosis in Hypercholesterolemic Mice

Autor: Thiago Rentz, Gabriel G. Dorighello, Renata R. dos Santos, Lohanna M. Barreto, Israelle N. Freitas, Carolina M. Lazaro, Daniela S. Razolli, Patricia M. Cazita, Helena C. F. Oliveira

Publikováno v: Biomolecules, Vol 13, Iss 10, p 1556 (2023)

CETP activity reduces plasma HDL-cholesterol concentrations, a correlate of an increased risk of atherosclerotic events. However, our recent findings suggest that CETP expression in macrophages promotes an intracellular antioxidant state, reduces fre

Externí odkaz: https://doaj.org/article/e92237ebb2d747e2802a20ff49b59a65

A20 deubiquitinase controls PGC-1α expression in the adipose tissue

Autor: Bruna Bombassaro, Leticia M. Ignacio-Souza, Carla E. Nunez, Daniela S. Razolli, Rafael M. Pedro, Andressa Coope, Eliana P. Araujo, Elinton A. Chaim, Licio A. Velloso

Publikováno v: Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-10 (2018)

Abstract Background Peroxisome proliferator-activated receptor γ coactivator- 1alpha (PGC-1α) plays an important role in whole body metabolism and, particularly in glucose homeostasis. Its expression is highly regulated and, small variations in tis

Externí odkaz: https://doaj.org/article/ec91e885e1644fa7ad3d26ebd8b30eed

The orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin

Autor: Pedro A.S. Nogueira, Alexandre Moura-Assis, Ariane M. Zanesco, Bruna Bombassaro, Ana L. Gallo-Ferraz, Marcela R. Simões, Daiane F. Engel, Daniela S. Razolli, Joana M. Gaspar, Jose Donato Junior, Licio A. Velloso

Publikováno v: Neuroscience letters. 792

GPR139 is an orphan G-protein-coupled receptor that is expressed in restricted areas of the nervous system, including the hypothalamus. In this study, we hypothesized that GPR139 could be involved in the regulation of energy balance and metabolism. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bba6b80c23bae96f94606ee572fb336
https://pubmed.ncbi.nlm.nih.gov/36347339

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

Autor: Silas Pinto, Bruna B. Brandão, Søren Nørvang Madsen, Jørn Wulff Helge, Jessica L. O. Branquinho, Marcelo A. Mori, Beatriz Alves Guerra, Sara G. Vienberg, Steen Larsen, Jan-Wilhelm Kornfeld, Ditte Søgaard, Daniela S. Razolli, Matteo Oliverio, Atefeh Rabiee, C. Ronald Kahn, Danilo Lopes Ferrucci, Thomas Nielsen, Gabriel Palermo Ruiz, William T. Festuccia, Juleen R. Zierath, Thiago L. Knittel, Adriano S. Martins, Brice Emanuelli, Jonas T. Treebak, Josef Brandauer, Licio A. Velloso

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Brandão, B B, Madsen, S, Rabiee, A, Oliverio, M, Ruiz, G P, Ferrucci, D L, Branquinho, J L, Razolli, D, Pinto, S, Nielsen, T S, Festuccia, W T, Martins, A S, Guerra, B A, Knittel, T L, Søgaard, D, Larsen, S, Helge, J W, Brandauer, J, Velloso, L A, Emanuelli, B, Kornfeld, J W, Kahn, C R, Vienberg, S G, Zierath, J R, Treebak, J T & Mori, M A 2020, ' Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 38, pp. 23932-23941 . https://doi.org/10.1073/pnas.2011243117
Proc Natl Acad Sci U S A

DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503d7036ed09be07ad12f921a505d0ac
https://doi.org/10.1073/pnas.2011243117

Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity

Autor: Licio A. Velloso, Daniela S. Razolli, Bruna Bombassaro, Alexandre Moura-Assis

Publikováno v: International Journal of Obesity. 43:2361-2369

The characterization of the hypothalamic neuronal network, that controls food intake and energy expenditure, has provided great advances in the understanding of the pathophysiology of obesity. Most of the advances in this field were obtained thanks t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9016e344db09eb6d12e517d9bf3ae9
https://doi.org/10.1038/s41366-019-0451-8