Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Daniela S, Thommen"'
Autor:
Tatjana Geukens, Maxim De Schepper, Wouter Van Den Bogaert, Karen Van Baelen, Marion Maetens, Anirudh Pabba, Amena Mahdami, Sophia Leduc, Edoardo Isnaldi, Ha-Linh Nguyen, Imane Bachir, Maysam Hajipirloo, Gitte Zels, Josephine Van Cauwenberge, Kristien Borremans, Vincent Vandecaveye, Birgit Weynand, Peter Vermeulen, Eleonora Leucci, Maria Francesca Baietti, George Sflomos, Laura Battista, Cathrin Brisken, Patrick W. B. Derksen, Thijs Koorman, Daan Visser, Colinda L. G. J. Scheele, Daniela S. Thommen, Sigrid Hatse, Sarah-Maria Fendt, Evy Vanderheyden, Thomas Van Brussel, Rogier Schepers, Bram Boeckx, Diether Lambrechts, Giuseppe Marano, Elia Biganzoli, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, François Richard, Giuseppe Floris, Christine Desmedt
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8
Externí odkaz:
https://doaj.org/article/64acb1b4e34a40a5a3f7576042fa573b
Autor:
Carolina Martinez-Ciarpaglini, Daniela S Thommen, Nicole C T van Grieken, Joep Grootjans, Sarah Derks, Tessa S Groen-van Schooten, Rosalia Franco Fernandez, Emma N Bos, Jens Seidel, Job Saris, Tania C Fleitas
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Tertiary lymphoid structures (TLSs) are thought to stimulate antitumor immunity and positively impact prognosis and response to immune checkpoint blockade. In gastric cancers (GCs), however, TLSs are predominantly found in GC with poor pro
Externí odkaz:
https://doaj.org/article/785d4f4c841145b58d42944ccbc30db0
Autor:
Karlijn Hummelink, Vincent van der Noort, Mirte Muller, Robert D Schouten, Michel M van den Heuvel, Daniela S Thommen, Egbert F Smit, Gerrit A Meijer, Kim Monkhorst
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0293707 (2024)
BackgroundThe efficacy of PD-1 blocking agents in advanced NSCLC has shown prolonged effectiveness, but only in a minority of patients. Multiple biomarkers have been explored to predict treatment benefit, yet their combined performance remains inadeq
Externí odkaz:
https://doaj.org/article/6b18e0bcb87f45658fff43824048aa27
Autor:
Marcel P. Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C. Stinchcombe, Michal A. Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T. Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S. Thommen, Gillian M. Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that
Externí odkaz:
https://doaj.org/article/fdf4b11832574e5fbfe57578d57e0309
Autor:
Lisanne M. Roelofsen, Paula Voabil, Marjolein de Bruijn, Petra Herzig, Alfred Zippelius, Ton N. Schumacher, Daniela S. Thommen
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102282- (2023)
Summary: The lack of suitable models currently hampers our understanding of how the tumor microenvironment responds to immunotherapy treatment. Here, we present a protocol for ex vivo culture of patient-derived tumor fragments (PDTFs). We describe th
Externí odkaz:
https://doaj.org/article/c2276a0502114ffd841cacb2749b9c77
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Neoadjuvant chemo(radio)therapy is part of the established standard of care in cancer treatment; neoadjuvant application of immunotherapy, however, is only performed within recent trials. Combination of programmed cell death protein 1 and cytotoxic T
Externí odkaz:
https://doaj.org/article/002ea29c4ad24282a7491ed9f244c524
Autor:
Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly
Table S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017a3c40264b8e2f69612f9eb8e7c603
https://doi.org/10.1158/2159-8290.22539473
https://doi.org/10.1158/2159-8290.22539473
Autor:
Alfred Zippelius, Didier Lardinois, Vaios Karanikas, Victor Levitsky, Spasenija Savic Prince, Wolfgang Moersig, Ozana S. Fischer, Marina Bacac, Christian Klein, Pavel Pisa, Pablo Umana, Anton Belousov, Andreas Roller, Petra Herzig, Philipp Müller, Jens Schreiner, Daniela S. Thommen
Dysfunctional T cells present in malignant lesions are characterized by a sustained and highly diverse expression of inhibitory receptors, also referred to as immune checkpoints. Yet, their relative functional significance in different cancer types r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dec2145384c4a5a58e14f99be122a0c0
https://doi.org/10.1158/2326-6066.c.6548741.v1
https://doi.org/10.1158/2326-6066.c.6548741.v1
Autor:
Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly
Identifying strategies to improve the efficacy of immune checkpoint blockade (ICB) remains a major clinical need. Here, we show that therapeutically targeting the COX2/PGE2/EP2-4 pathway with widely used nonsteroidal and steroidal anti-inflammatory d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8984675ccc2ee02aad006ca4186bf241
https://doi.org/10.1158/2159-8290.c.6549104.v1
https://doi.org/10.1158/2159-8290.c.6549104.v1
Autor:
Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly
Supplementary Figures and supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368b85f9b253cc646efd59ce772aa109
https://doi.org/10.1158/2159-8290.22539494.v1
https://doi.org/10.1158/2159-8290.22539494.v1