Výsledky vyhledávání - "Daniela Rebleanu"

Akademický článek

Tri-Component Hydrogel as Template for Nanocrystalline Hydroxyapatite Deposition Using Alternate Soaking Method for Bone Tissue Engineering Applications

Autor: Irina Mihaela Pelin, Irina Popescu, Manuela Calin, Daniela Rebleanu, Geanina Voicu, Daniela Ionita, Marius-Mihai Zaharia, Marieta Constantin, Gheorghe Fundueanu

Publikováno v: Gels, Vol 9, Iss 11, p 905 (2023)

Composite hydrogels containing apatite-like particles can act as scaffolds for osteoblast proliferation, with applications in bone tissue engineering. In this respect, porous biocompatible hydrogels were obtained from chitosan, oxidized pullulan, and

Externí odkaz: https://doaj.org/article/8d43d6aa5c8d4d1e87c4e269b4079cdf

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Akademický článek

Integrins α4β1 and αVβ3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease

Autor: Alexandru Filippi, Alina Constantin, Nicoleta Alexandru, Geanina Voicu, Cristina Ana Constantinescu, Daniela Rebleanu, Madalina Fenyo, Dan Simionescu, Agneta Simionescu, Ileana Manduteanu, Adriana Georgescu

Publikováno v: Cell Transplantation, Vol 29 (2020)

Diabetes reduces the number and induces dysfunction in circulating endothelial progenitor cells (EPCs) by mechanisms that are still uncovered. This study aims to evaluate the number, viability, phenotype, and function of EPCs in dyslipidemic mice wit

Externí odkaz: https://doaj.org/article/5dd1edf56e3e479bb6edb3c032e323b6

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Akademický článek

Evaluation of VCAM-1 Targeted Naringenin/Indocyanine Green-Loaded Lipid Nanoemulsions as Theranostic Nanoplatforms in Inflammation

Autor: Elena Valeria Fuior, Cristina Ana Mocanu, Mariana Deleanu, Geanina Voicu, Maria Anghelache, Daniela Rebleanu, Maya Simionescu, Manuela Calin

Publikováno v: Pharmaceutics, Vol 12, Iss 11, p 1066 (2020)

Naringenin, an anti-inflammatory citrus flavonoid, is restrained from large-scale use by its reduced water solubility and bioavailability. To overcome these limitations, naringenin was loaded into lipid nanoemulsions directed towards vascular cell ad

Externí odkaz: https://doaj.org/article/d16072d8947a474daaf6d4ee6a00dbf6

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Akademický článek

Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells

Autor: Geanina Voicu, Daniela Rebleanu, Cristina Ana Constantinescu, Elena Valeria Fuior, Letitia Ciortan, Ionel Droc, Cristina Mariana Uritu, Mariana Pinteala, Ileana Manduteanu, Maya Simionescu, Manuela Calin

Publikováno v: Pharmaceutics, Vol 12, Iss 6, p 507 (2020)

Calcific aortic valve disease (CAVD) is a progressive disorder that increases in prevalence with age. An important role in aortic valve calcification is played by valvular interstitial cells (VIC), that with age or in pathological conditions acquire

Externí odkaz: https://doaj.org/article/302637c320594555b27075842a832b9a

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Akademický článek

Functional Role of VCAM-1 Targeted Flavonoid-Loaded Lipid Nanoemulsions in Reducing Endothelium Inflammation

Autor: Elena Valeria Fuior, Mariana Deleanu, Cristina Ana Constantinescu, Daniela Rebleanu, Geanina Voicu, Maya Simionescu, Manuela Calin

Publikováno v: Pharmaceutics, Vol 11, Iss 8, p 391 (2019)

Citrus flavonoids have well-documented protective effects on cardiovascular system, but the poor water solubility and reduced bioavailability restrict their therapeutic use. We aimed to overcome these limitations and encapsulated naringenin and hespe

Externí odkaz: https://doaj.org/article/bd002a20e3ad4d4795cefe4111a6789f

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Akademický článek

Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells

Autor: Cristina Ana Constantinescu, Elena Valeria Fuior, Daniela Rebleanu, Mariana Deleanu, Viorel Simion, Geanina Voicu, Virginie Escriou, Ileana Manduteanu, Maya Simionescu, Manuela Calin

Publikováno v: Pharmaceutics, Vol 11, Iss 1, p 47 (2019)

The progress in small-interfering RNA (siRNA) therapeutics depends on the development of suitable nanocarriers to perform specific and effective delivery to dysfunctional cells. In this paper, we questioned whether P-selectin, a cell adhesion molecul

Externí odkaz: https://doaj.org/article/883434eee82a441984581ae8772b6655

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Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe

Autor: Maya Simionescu, Simona-Adriana Manea, Daniela Rebleanu, A.G. Lazar, Adrian Manea, Manuela Calin, Ioana Madalina Fenyo, Mihaela-Loredana Vlad

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)

Excessive production of reactive oxygen species (ROS) and the ensuing oxidative stress are instrumental in all phases of atherosclerosis. Despite the major achievements in understanding the regulatory pathways and molecular sources of ROS in the vasc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee43390c914480c3cd9d397baa2d9d6
https://doi.org/10.1155/2021/6685612

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VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment

Autor: Geanina Voicu, Daniela Rebleanu, Cristina Ana Mocanu, Gabriela Tanko, Ionel Droc, Cristina Mariana Uritu, Mariana Pinteala, Ileana Manduteanu, Maya Simionescu, Manuela Calin

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3824

Calcific aortic valve disease (CAVD) is a progressive inflammatory disorder characterized by extracellular matrix remodeling and valvular interstitial cells (VIC) osteodifferentiation leading to valve leaflets calcification and impairment movement. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3a6070c891a7d831d7df09c51f5698
https://pubmed.ncbi.nlm.nih.gov/35409184

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P-selectin targeted RAGE-shRNA lipoplexes alleviate atherosclerosis-associated inflammation

Autor: Mariana Deleanu, Maya Simionescu, Ioana Madalina Fenyo, Elena Valeria Fuior, Cristina Ana Mocanu, Florentina Safciuc, Virginie Escriou, Geanina Voicu, Ileana Manduteanu, Manuela Calin, Daniela Rebleanu

Publikováno v: Journal of Controlled Release
Journal of Controlled Release, Elsevier, 2021, 338, pp.754-772. ⟨10.1016/j.jconrel.2021.09.012⟩
Journal of Controlled Release, 2021, 338, pp.754-772. ⟨10.1016/j.jconrel.2021.09.012⟩

The receptor for advanced glycation end products (RAGE) plays a central role in the chronic inflammatory process associated with atherosclerosis development. We aimed to develop lipoplexes carrying RAGE-short hairpin (sh) RNA, targeted to the adhesio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60b5ec3944dae583efe9351b49afe9f
https://hal-cnrs.archives-ouvertes.fr/hal-03407602

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