Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

Autor: Neha Mishra, Magdalena Westermann, Nina Sommer, Philip Rosenstiel, Fredrik Bäckhed, Dora Bordoni, Marijana Basic, Christoph Kaleta, Johannes Zimmermann, Lena Schröder, Felix Sommer, Kenneth Klischies, Stefan Krautwald, Georgios Marinos, Simon Imm, Ruth A. Schmitz, Bärbel Stecher, Kensuke Shima, Jan Rupp, Jacob Hamm, Valentina Tremaroli, Finn Hinrichsen, Robert Häsler, Philippe Schmitt-Kopplin, Alesia Walker, Andrea J. Wolf, Antonella Fazio, Daniela Prasse, Sina Kaiser, Georg Laue

Publikováno v: Cell Metab. 33, 2355-2366.e8 (2021)
Hinrichsen, F, Hamm, J, Westermann, M, Schröder, L, Shima, K, Mishra, N, Walker, A, Sommer, N, Klischies, K, Prasse, D, Zimmermann, J, Kaiser, S, Bordoni, D, Fazio, A, Marinos, G, Laue, G, Imm, S, Tremaroli, V, Basic, M, Häsler, R, Schmitz, R A, Krautwald, S, Wolf, A, Stecher, B, Schmitt-Kopplin, P, Kaleta, C, Rupp, J, Bäckhed, F, Rosenstiel, P & Sommer, F 2021, ' Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis ', Cell Metabolism, vol. 33, no. 12, pp. 2355-2366.e8 . https://doi.org/10.1016/j.cmet.2021.11.004

Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly expressed in gut epithelium, contributes to immune responses, and is upregulated during inflammation. We examined the microbial regulation of HK2 and its impact o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ff874f57137415da69016c677d9213
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63735

Cover Image

Autor: Nancy Weiland‐Bräuer, Daniela Prasse, Annika Brauer, Cornelia Jaspers, Thorsten B. H. Reusch, Ruth A. Schmitz

Publikováno v: MicrobiologyOpen. 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f65975717874aeed2f2362124be8f898
https://doi.org/10.1002/mbo3.1123

Evaluating the quorum quenching potential of bacteria associated to Aurelia aurita and Mnemiopsis leidyi

Autor: Nancy Weiland-Bräuer, Cornelia Jaspers, Thorsten B. H. Reusch, Ruth A. Schmitz, Daniela Prasse

Publikováno v: Prasse, D, Weiland-Bräuer, N, Jaspers, C, Reusch, T B H & Schmitz, R A 2019, ' Evaluating the quorum quenching potential of bacteria associated to Aurelia aurita and Mnemiopsis leidyi ', bioRxiv . https://doi.org/10.1101/602268
(Submitted) PLoS ONE .

The associated microbiota of marine invertebrates plays an important role to the host in relation to fitness, health and homeostasis of the metaorganism. As one key chemically-mediated interaction, Quorum sensing (QS) and interference with QS among c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a9ff07916ebebf2f9c4cf17e6b74e7
https://orbit.dtu.dk/en/publications/fc8cfd47-6df6-4326-9d45-0fce23c9bd17

Functions of the microbiota for the physiology of animal metaorganisms

Autor: Cornelia Jaspers, Daniela Esser, Daniela Prasse, Michael Sieber, Georgios Marinos, Felix Sommer, Jay Bathia, Malte C. Rühlemann, Janina Lange, Kathrin Boersch, Lena Best

Publikováno v: Esser, D, Lange, J, Marinos, G, Sieber, M, Best, L, Prasse, D, Bathia, J, Rühlemann, M, Boersch, K, Jaspers, C & Sommer, F 2018, ' Functions of the microbiota for the physiology of animal metaorganisms ', Journal of Innate Immunity, vol. 11, no. 5, pp. 393-404 . https://doi.org/10.1159/000495115
Journal of Innate Immunity, 11 (5). pp. 393-404.
Journal of Innate Immunity

Animals are usually regarded as independent entities within their respective environments. However, within an organism, eukaryotes and prokaryotes interact dynamically to form the so-called metaorganism or holobiont, where each partner fulfils its ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3defdef4dcaa2614c24ab4ed10790b
https://orbit.dtu.dk/en/publications/b05e2be6-4e8b-48b2-986d-79d031296cd8

sRNA154 a newly identified regulator of nitrogen fixation in Methanosarcina mazei strain Gö1

Autor: Konrad U. Förstner, Dominik Jäger, Ruth A. Schmitz, Daniela Prasse, Rolf Backofen

Trans-encoded sRNA154 is exclusively expressed under nitrogen (N)-deficiency in Methanosarcina mazei strain Gö1. The sRNA154 deletion strain showed a significant decrease in growth under N-limitation, pointing towards a regulatory role of sRNA154 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0af5a44504d59e8f9e40283e414676