Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Daniela Peneda Pacheco"'
Publikováno v:
Molecular Pharmaceutics. 19:520-531
Mucus represents a strong barrier to tackle for oral or pulmonary administered drugs, especially in mucus-related disorders. This study uses a pathological cystic fibrosis (CF) mucus model to investigate how mucus impacts the passive diffusion of 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4623263d8a128e2783b673e6fe3cbce9
https://doi.org/10.1021/acs.molpharmaceut.1c00644
https://doi.org/10.1021/acs.molpharmaceut.1c00644
Publikováno v:
Biomaterials Science. 9:70-83
Engineered models have emerged as relevant in vitro tools to foresee the translational potential of new therapies from the bench to the bedside in a fast and cost-effective fashion. The principles applied to the development of tissue-engineered const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7388c78a7385d905aca6ceef881206e
https://doi.org/10.1039/d0bm01097a
https://doi.org/10.1039/d0bm01097a
Autor:
Shuaizhong Zhang, Daniela Peneda Pacheco, Lucia Pedersoli, Ruth Cardinaels, Paola Petrini, Francesco Briatico-Vangosa, Jaap M.J. den Toonder
Publikováno v:
Biotechnology and Bioengineering
Biotechnology and Bioengineering, 118(10), 3898-3913. Wiley-VCH Verlag
Biotechnology and Bioengineering, 118(10), 3898-3913. Wiley-VCH Verlag
Mucociliary clearance is a crucial mechanism that supports the elimination of inhaled particles, bacteria, pollution and hazardous agents from the human airways, and it also limits the diffusion of aerosolized drugs into the airway epithelium. In spi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c4eb4f34a755e3470deeb560c011bc
https://pubmed.ncbi.nlm.nih.gov/34143430
https://pubmed.ncbi.nlm.nih.gov/34143430
Publikováno v:
Biomaterials science. 9(1)
Engineered models have emerged as relevant in vitro tools to foresee the translational potential of new therapies from the bench to the bedside in a fast and cost-effective fashion. The principles applied to the development of tissue-engineered const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b496e405601b157d2987d7126e280529
https://pubmed.ncbi.nlm.nih.gov/33191420
https://pubmed.ncbi.nlm.nih.gov/33191420
Autor:
Livia Visai, Francesco Briatico Vangosa, Paola Petrini, Sonja Visentin, Laura Pastorino, Cosmin Butnarasu, Daniela Peneda Pacheco
Publikováno v:
Journal of Materials Chemistry B. 7:4940-4952
Mucus is a natural barrier with a protective role that hinders drug diffusion, representing a steric and interactive barrier to overcome for an effective drug delivery to target sites. In diseases like cystic fibrosis (CF), pulmonary mucus exhibits a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88244affa4f7855e194e9e7a3b8ad092
https://doi.org/10.1039/c9tb00957d
https://doi.org/10.1039/c9tb00957d
Autor:
Lorenzo, Sardelli, Daniela Peneda, Pacheco, Anna, Ziccarelli, Marta, Tunesi, Omar, Caspani, Andrea, Fusari, Francesco, Briatico Vangosa, Carmen, Giordano, Paola, Petrini
Publikováno v:
RSC advances. 9(28)
Intestinal mucus is a biological structure that acts as a barrier between the external environment and the epithelium. It actively selects nutrient and drug intake, regulates the symbiosis with the intestinal microbiota and keeps the epithelium prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49146d40fec380464d708e872de99000
https://pubmed.ncbi.nlm.nih.gov/35521409
https://pubmed.ncbi.nlm.nih.gov/35521409
Autor:
Daniela Peneda Pacheco, Laura Zorzetto, Lorenzo Sardelli, Wojciech Święszkowski, Paola Petrini, Chiara Rinoldi
Publikováno v:
Journal of Applied Biomaterials & Functional Materials, Vol 17 (2019)
Biological gradients profoundly influence many cellular activities, such as adhesion, migration, and differentiation, which are the key to biological processes, such as inflammation, remodeling, and tissue regeneration. Thus, engineered structures co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497038f7074de0af7a9a088b7411976d
https://pubmed.ncbi.nlm.nih.gov/30803308
https://pubmed.ncbi.nlm.nih.gov/30803308
Mucin is a complex glycoprotein consisting of a wide variety of functional groups that can interact with exogenous agents. The binding to mucin plays a crucial role in drug pharmacokinetics especially in diseases, such as cystic fibrosis (CF), where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c9c6129447ccaa0b8436131bbf64c7
http://hdl.handle.net/11311/1123519
http://hdl.handle.net/11311/1123519
Development of an injectable PHBV microparticles-GG hydrogel hybrid system for regenerative medicine
Autor:
Daniela Peneda Pacheco, Rui L. Reis, Alexandra P. Marques, Vitor M. Correlo, Maria Helena Amaral
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
International Journal of Pharmaceutics
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
International Journal of Pharmaceutics
Uncontrollable displacements that greatly affect the concentration of active agents at the target tissues are among a major limitation of the use of microparticulate drug delivery systems (DDS). Under this context a biphasic injectable DDS combining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f9b3869a6263e9fa845b6fc127c735