Výsledky vyhledávání - "Daniela Pemp"

Influence of breast cancer risk factors and intramammary biotransformation on estrogen homeostasis in the human breast

Autor: Carolin Kleider, Daniela Pemp, Claudia Wigmann, Katja Schmalbach, Leane Lehmann, Leo N. Geppert, Katja Ickstadt, René Hauptstein, Harald L. Esch

Publikováno v: Archives of Toxicology

Understanding intramammary estrogen homeostasis constitutes the basis of understanding the role of lifestyle factors in breast cancer etiology. Thus, the aim of the present study was to identify variables influencing levels of the estrogens present i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a202199371d147097c755fb5954c307d
http://europepmc.org/articles/PMC7415756

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Validation of a GC- and LC-MS/MS based method for the quantification of 22 estrogens and its application to human plasma

Autor: Carolin, Kleider, Jeniffer, Calderón Giraldo, Daniela, Pemp, Harald L, Esch, Leane, Lehmann

Publikováno v: Steroids. 186:109077

In epidemiological studies, blood levels of 17β-estradiol (E2) are associated with hormone-dependent diseases. The lack of specific methods impedes studies on the role of E2 metabolites and their conjugates in the etiology of hormone-dependent disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a432ea52f09a87eb67f8aa0c3958a125
https://doi.org/10.1016/j.steroids.2022.109077

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Influence of breast cancer risk factors on proliferation and DNA damage in human breast glandular tissues: role of intracellular estrogen levels, oxidative stress and estrogen biotransformation

Autor: Juliane Wunder, Daniela Pemp, Alexander Cecil, Maryam Mahdiani, René Hauptstein, Katja Schmalbach, Leo N. Geppert, Katja Ickstadt, Harald L. Esch, Thomas Dandekar, Leane Lehmann

Publikováno v: Archives of toxicology. 96(2)

Breast cancer etiology is associated with both proliferation and DNA damage induced by estrogens. Breast cancer risk factors (BCRF) such as body mass index (BMI), smoking, and intake of estrogen-active drugs were recently shown to influence intratiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c040c0ad8ca9d3b55458c7e55a810bc8
https://pubmed.ncbi.nlm.nih.gov/34921608

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Qualitative and quantitative differences in estrogen biotransformation in human breast glandular and adipose tissues: implications for studies using mammary biospecimens

Autor: Peter Eckert, Katja Schmalbach, Daniela Pemp, Harald L. Esch, Iva Neshkova, Rafael G. Jakubietz, Leo N. Geppert, René Hauptstein, Katja Ickstadt, Leane Lehmann, Carolin Kleider, Claudia Köllmann

Publikováno v: Archives of Toxicology. 93:2823-2833

Because of its assumed role in breast cancer etiology, estrogen biotransformation (and interaction of compounds therewith) has been investigated in human biospecimens for decades. However, little attention has been paid to the well-known fact that la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0337ffc3fdcc31701a54476fdac5969d
https://doi.org/10.1007/s00204-019-02564-w

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Novel insight in estrogen homeostasis and bioactivity in the ACI rat model of estrogen-induced mammary gland carcinogenesis

Autor: Daniela Pemp, Günter Vollmer, Katharina Schlereth, Leane Lehmann, Maarten C. Bosland, Harald L. Esch, Carolin Kleider, Leo N. Geppert, René Hauptstein, Frank Möller, Oliver Zierau

Publikováno v: Archives of toxicology. 93(7)

Despite being widely used to investigate 17β-estradiol (E2)-induced mammary gland (MG) carcinogenesis and prevention thereof, estrogen homeostasis and its significance in the female August Copenhagen Irish (ACI) rat model is unknown. Thus, levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689ccc6bc9e8e4dd98e05f48867a0e5d
https://pubmed.ncbi.nlm.nih.gov/31119341

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Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB2R selective benzimidazoles reveal unexpected intrinsic properties

Autor: Daniela Pemp, Michael Decker, Fouad H. Darras, Jörg Heilmann, Xinyu Chen, Martin Nimczick

Publikováno v: Bioorganic & Medicinal Chemistry. 22:3938-3946

The design of bivalent ligands targeting G protein-coupled receptors (GPCRs) often leads to the development of new, highly selective and potent compounds. To date, no bivalent ligands for the human cannabinoid receptor type 2 (hCB2R) of the endocanna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54f9f9ab15465b97ebc3f153673a2d72
https://doi.org/10.1016/j.bmc.2014.06.008

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Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats

Autor: Xiajie Zhang, Sabine E. Kulling, Daniela Pemp, Günter Vollmer, Michael H. Muders, Sebastian T. Soukup, Kathleen Wende, Maarten C. Bosland, Leane Lehmann, Frank Möller, Oliver Zierau

Publikováno v: Archives of toxicology. 90(8)

There is an ongoing debate whether the intake of soy-derived isoflavones (sISO) mediates beneficial or adverse effects with regard to breast cancer risk. Therefore, we investigated whether nutritional exposure to a sISO-enriched diet from conception

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2251c0cf06b7ebeddfe19c0ee2d60e3
https://pubmed.ncbi.nlm.nih.gov/26861028

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