Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Daniela N Männel"'
Autor:
Tobias Schmid, Lena Falter, Sabine Weber, Nils Müller, Konstantin Molitor, David Zeller, Dorothea Weber-Steffens, Thomas Hehlgans, Harald Wajant, Sven Mostböck, Daniela N. Männel
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
TNF receptor type 2 (TNFR2) has gained attention as a costimulatory receptor for T cells and as critical factor for the development of regulatory T cells (Treg) and myeloid suppressor cells. Using the TNFR2-specific agonist TNCscTNF80, direct effects
Externí odkaz:
https://doaj.org/article/2350445363bd4deea143a14df744bc25
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159059 (2016)
To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress. CSC substantially affected the cell composit
Externí odkaz:
https://doaj.org/article/5b46e7d46cce4c7bbfdb2a01fb8601b3
Autor:
Melanie Werner-Klein, Judith Proske, Christian Werno, Katharina Schneider, Hans-Stefan Hofmann, Brigitte Rack, Stefan Buchholz, Roman Ganzer, Andreas Blana, Birgit Seelbach-Göbel, Ulrich Nitsche, Daniela N Männel, Christoph A Klein
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97860 (2014)
Tumor xenografts in immunodeficient mice, while routinely used in cancer research, preclude studying interactions of immune and cancer cells or, if humanized by allogeneic immune cells, are of limited use for tumor-immunological questions. Here, we e
Externí odkaz:
https://doaj.org/article/30ba7c73c8eb4301b914939c5ca731dc
Autor:
Thomas Barth, Dominic Schmidt, Catherine Botteron, Trang T T Nguyen, Uwe Ritter, Daniela N Männel, Anja Lechner
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44499 (2012)
Resistance to Leishmania major infection is dependent on the development of a cell-mediated Th1 immune response in resistant C57BL/6 mice whereas Th2-prone BALB/c mice develop non-healing lesions after infection. The chemokine receptor CCR6 is shared
Externí odkaz:
https://doaj.org/article/57050feeead24eb6976f0fe666cf5d1c
Autor:
Rainer H. Straub, Vanessa Lamontain, Zsuzsa Jenei-Lanzl, Harald Wajant, Daniela N. Männel, David Zeller, Tobias Schmid, Dorothea Weber-Steffens
Publikováno v:
Cellular & Molecular Immunology. 16:65-74
Tumor necrosis factor (TNF) and its receptors TNF receptor type 1 (TNFR1) and type 2 (TNFR2) have a central role in chronic inflammatory diseases. While TNFR1 mainly confers inflammation, activation of TNFR2 elicits not only pro-inflammatory but also
Autor:
Johann Pötzl, Catherine Botteron, Eugen Tausch, Xiomara Pedré, André M Mueller, Daniela N Männel, Anja Lechner
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2951 (2008)
BACKGROUND: The function of T helper cell subsets in vivo depends on their location, and one hallmark of T cell differentiation is the sequential regulation of migration-inducing chemokine receptor expression. CC-chemokine receptor 6 (CCR6) is a trai
Externí odkaz:
https://doaj.org/article/90e83cd53870489e8a6c339bc91e4547
Autor:
Uwe Ritter, Matthias Edinger, Petra Hoffmann, Nicole Zimara, Maximilian Schmid, Christian Florian, Adrien Kissenpfennig, James A. Hutchinson, Daniela N. Männel, Bernard Malissen
Publikováno v:
European Journal of Immunology. 44:2955-2967
Efficient formation of early GCs depends on the close interaction between GC B cells and antigen-primed CD4+ follicular helper T cells (TFH). A tight and stable formation of TFH/B cell conjugates is required for cytokine-driven immunoglobulin class s
Autor:
Annika Remke, Johannes Polz, Daniela N. Männel, Uwe Ritter, Anne Pietryga-Krieger, Dorothea Weber-Steffens, Sabine Weber, Nils Müller, Dominic Schmidt, Sven Mostböck
Publikováno v:
Immunity, Inflammation and Disease
TNF and TNF receptor type 2 (TNFR2) have been shown to be important for generation of myeloid-derived suppressor cells (MDSC). In order to analyze whether and how TNFR2 passes the effect of TNF on, myeloid cells from TNFR2-deficient mice were compare
Autor:
Wolfgang Ernst, Frank Hanses, Daniela N. Männel, Nicole Zimara, Anja K. Wege, Birgit Seelbach-Göbel
Publikováno v:
Infection and Immunity. 81:1520-1531
Bacterial infection with group B Streptococcus (GBS) represents a prominent threat to neonates and fetuses in the Western world, causing severe organ damage and even death. To improve current therapeutic strategies and to investigate new approaches,
Autor:
Rafaela Holtappels, Andrea Fick, Jeanette Baker, Harald Wajant, Matthias J. Reddehase, Thomas Müller, Daniela N. Männel, Andreas Brandl, Thorsten Winter, Viktoria Schäfer, Hermann Einsele, Carina A. Bäuerlein, Axel Seher, Jürgen Podlech, Sabrina Kraus, Johannes Polz, Eliana Ribechini, Tim Steinfatt, Sven Krappmann, Janina Kuen, Juliane Kums, Jorge Amich, Andreas Beilhack, Hidekazu Nishikii, Katja J. Ottmüller, Friederike Berberich-Siebelt, Anja Mottok, Manfred B. Lutz, Miriam Ritz, Ana-Laura Jordán-Garrote, Martin Vaeth, Katharina Mattenheimer, Christian Brede, Stefanie Schwinn, Martin Chopra, Marlene Biehl
Publikováno v:
The Journal of Experimental Medicine
Chopra, M, Biehl, M, Steinfatt, T, Brandl, A, Kums, J, Amich Elias, J, Vaeth, M, Kuen, J, Holtappels, R, Podlech, J, Mottok, A, Kraus, S, Jordán-Garrote, A-L, Bäuerlein, C A, Brede, C, Ribechini, E, Fick, A, Seher, A, Polz, J, Ottmüller, K J, Baker, J, Nishikii, H, Ritz, M, Mattenheimer, K, Schwinn, S, Winter, T, Schäfer, V, Krappmann, S, Einsele, H, Müller, T D, Reddehase, M J, Lutz, M B, Männel, D N, Berberich-Siebelt, F, Wajant, H & Beilhack, A 2016, ' Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion ', Journal of Experimental Medicine, vol. 213, no. 9, pp. 1881–1900 . https://doi.org/10.1084/jem.20151563
Chopra, M, Biehl, M, Steinfatt, T, Brandl, A, Kums, J, Amich Elias, J, Vaeth, M, Kuen, J, Holtappels, R, Podlech, J, Mottok, A, Kraus, S, Jordán-Garrote, A-L, Bäuerlein, C A, Brede, C, Ribechini, E, Fick, A, Seher, A, Polz, J, Ottmüller, K J, Baker, J, Nishikii, H, Ritz, M, Mattenheimer, K, Schwinn, S, Winter, T, Schäfer, V, Krappmann, S, Einsele, H, Müller, T D, Reddehase, M J, Lutz, M B, Männel, D N, Berberich-Siebelt, F, Wajant, H & Beilhack, A 2016, ' Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion ', Journal of Experimental Medicine, vol. 213, no. 9, pp. 1881–1900 . https://doi.org/10.1084/jem.20151563
Activation of TNFR2 with a novel agonist expands T reg cells in vivo and protects allo-HCT recipients from acute GvHD while sparing antilymphoma and antiinfectious properties of transplanted donor T cells.
Donor CD4+Foxp3+ regulatory T cells (T
Donor CD4+Foxp3+ regulatory T cells (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6a4988c207afd66c5d8de16a6bb555
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/18764
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/18764