Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Daniela Moralli"'
Autor:
Maciej Kliszczak, Daniela Moralli, Julia D. Jankowska, Paulina Bryjka, Lamia Subha Meem, Tomas Goncalves, Svenja S. Hester, Roman Fischer, David Clynes, Catherine M. Green
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Hereditary fibrosing poikiloderma (HFP) is a rare human dominant negative disorder caused by mutations in the FAM111B gene that encodes a nuclear trypsin-like serine protease. HFP patients present with symptoms including skin abnormalities, tendon co
Externí odkaz:
https://doaj.org/article/2b3ff36c5f3d4ac2a5aff013ae00c0a5
Autor:
Sabrina Sailer, Stefan Coassin, Katharina Lackner, Caroline Fischer, Eileen McNeill, Gertraud Streiter, Christian Kremser, Manuel Maglione, Catherine M. Green, Daniela Moralli, Alexander R. Moschen, Markus A. Keller, Georg Golderer, Gabriele Werner-Felmayer, Irmgard Tegeder, Keith M. Channon, Benjamin Davies, Ernst R. Werner, Katrin Watschinger
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Background Genome editing in mice using either classical approaches like homologous recombination or CRISPR/Cas9 has been reported to harbor off target effects (insertion/deletion, frame shifts or gene segment duplications) that lead to muta
Externí odkaz:
https://doaj.org/article/8ea297638f64458d935a9b1e4923a4b5
Autor:
Stefan Antonowicz, Zsolt Bodai, Tom Wiggins, Sheraz R. Markar, Piers R. Boshier, Yan Mei Goh, Mina E. Adam, Haonan Lu, Hiromi Kudo, Francesca Rosini, Robert Goldin, Daniela Moralli, Catherine M. Green, Chris J. Peters, Nagy Habib, Hani Gabra, Rebecca C. Fitzgerald, Zoltan Takats, George B. Hanna
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Volatile aldehydes can be enriched in esophageal adenocarcinoma patients’ breath. Here, the authors reveal corresponding metabolic changes in EAC tumours, which may be caused by impaired detoxification of endogenous metabolites.
Externí odkaz:
https://doaj.org/article/c4cb39fcd5d245a5814461336da92aeb
Autor:
Louisa Nelson, Anthony Tighe, Anya Golder, Samantha Littler, Bjorn Bakker, Daniela Moralli, Syed Murtuza Baker, Ian J. Donaldson, Diana C. J. Spierings, René Wardenaar, Bethanie Neale, George J. Burghel, Brett Winter-Roach, Richard Edmondson, Andrew R. Clamp, Gordon C. Jayson, Sudha Desai, Catherine M. Green, Andy Hayes, Floris Foijer, Robert D. Morgan, Stephen S. Taylor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
High-grade serous ovarian carcinoma is often associated with TP53 mutation and chromosomal instability (CIN). Here, the authors generate ex vivo cultures from biopsies and ascites of patients and perform characterization to evaluate CIN mechanisms an
Externí odkaz:
https://doaj.org/article/5f96b03935524c6e8d18bbc5878047b4
Autor:
Daniel Wells, Emmanuelle Bitoun, Daniela Moralli, Gang Zhang, Anjali Hinch, Julia Jankowska, Peter Donnelly, Catherine Green, Simon R Myers
Publikováno v:
eLife, Vol 9 (2020)
During meiosis, homologous chromosomes pair and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3
Externí odkaz:
https://doaj.org/article/d1a82872483147549421c34c8c933946
Autor:
Mirna R. Tenan, Adeline Nicolle, Daniela Moralli, Emeline Verbouwe, Julia D. Jankowska, Mary-Anne Durin, Catherine M. Green, Stefano J. Mandriota, André-Pascal Sappino
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9515 (2021)
Chromosome instability (CIN) consists of high rates of structural and numerical chromosome abnormalities and is a well-known hallmark of cancer. Aluminum is added to many industrial products of frequent use. Yet, it has no known physiological role an
Externí odkaz:
https://doaj.org/article/ff5d6cf2887e4e06bb94b8f6c8f47193
Autor:
Inês J. de Castro, James Budzak, Maria L. Di Giacinto, Lorena Ligammari, Ezgi Gokhan, Christos Spanos, Daniela Moralli, Christine Richardson, Jose I. de las Heras, Silvia Salatino, Eric C. Schirmer, Katharine S. Ullman, Wendy A. Bickmore, Catherine Green, Juri Rappsilber, Sarah Lamble, Martin W. Goldberg, Veronica Vinciotti, Paola Vagnarelli
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Repo-Man is a chromosome-binding subunit of protein phosphatase 1 to regulate mitosis. Here, de Castro and colleagues show that Repo-Man also regulates heterochromatin during interphase, and regulates gene repression and chromatin organization.
Externí odkaz:
https://doaj.org/article/614dab2625cb407a8fec9084fc97d570
Autor:
Mandeep S. Singh, Jasmin Balmer, Alun R. Barnard, Sher A. Aslam, Daniela Moralli, Catherine M. Green, Alona Barnea-Cramer, Isabel Duncan, Robert E. MacLaren
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-5 (2016)
Previous studies have used fluorescently labelled cells to demonstrate the incorporation of transplanted photoreceptor precursors into the mouse retina. Here, the authors show that fluorescent proteins are passed between the host and transplanted cel
Externí odkaz:
https://doaj.org/article/a152f0eaffda4bcba6ad872e86359ba3
Autor:
Susana Simões-Sousa, Samantha Littler, Sarah L. Thompson, Paul Minshall, Helen Whalley, Bjorn Bakker, Klaudyna Belkot, Daniela Moralli, Daniel Bronder, Anthony Tighe, Diana C.J. Spierings, Nourdine Bah, Joshua Graham, Louisa Nelson, Catherine M. Green, Floris Foijer, Paul A. Townsend, Stephen S. Taylor
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 749-760.e6 (2018)
Summary: Deviating from the normal karyotype dramatically changes gene dosage, in turn decreasing the robustness of biological networks. Consequently, aneuploidy is poorly tolerated by normal somatic cells and acts as a barrier to transformation. Par
Externí odkaz:
https://doaj.org/article/10e545c8d9c94b2db1c779b63426b431
Autor:
Stefano J. Mandriota, Mirna Tenan, Adeline Nicolle, Julia D. Jankowska, Paolo Ferrari, Jean-Christophe Tille, Mary-Anne Durin, Catherine M. Green, Sebastien Tabruyn, Daniela Moralli, André-Pascal Sappino
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9332 (2020)
Genomic instability is generally considered as a hallmark of tumorigenesis and a prerequisite condition for malignant transformation. Aluminium salts are suspected environmental carcinogens that transform mammary epithelial cells in vitro through unk
Externí odkaz:
https://doaj.org/article/01bacd7ef39945558503328bebbb9abc