Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Daniela Masi"'
Autor:
Daniela Masi, Kalyan K. Sadhu, Aurélien Roux, Jacques Saarbach, Nicolas Winssinger, Valentina Galli
Publikováno v:
Helvetica Chimica Acta, Vol. 103, No e1900255 (2020) pp. 1-10
The cellular delivery of oligonucleotides has been a major obstacle in the development of therapeutic antisense agents. PNAs (Peptide Nucleic Acid) are unique in providing a modular peptidic backbone that is amenable to structural and charge modulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b81025b094e7952bf2874df1cd72cd5
https://archive-ouverte.unige.ch/unige:129366
https://archive-ouverte.unige.ch/unige:129366
Publikováno v:
Bioorganic & Medicinal Chemistry, Vol. 25, No 19 (2017) pp. 5171-5177
Peptide nucleic acids (PNAs) derivatized with functional molecules are increasingly used in diverse biosupramolecular applications. PNAs have proven to be highly tolerant to modifications and different applications benefit from the use of modified PN
Autor:
Stuart L. Schreiber, Daniela Masi, Carol Mulrooney, Roger C. Wiegand, Mark E. Fitzgerald, Christina Scherer, Michelle Palmer, Richard W. Heidebrecht, Jennifer A. Beaudoin, Benito Munoz, Amanda K. Lukens, Eamon Comer, Dyann F. Wirth, Jeremy R. Duvall, Michael Foley, Kevin Galinsky
Publikováno v:
The Journal of Infectious Diseases
Massachusetts Background. The emergence and spread of drug resistance to current antimalarial therapies remains a pressing concern, escalating the need for compounds that demonstrate novel modes of action. Diversity-Oriented Synthesis (DOS) libraries
Autor:
Gianpaolo, Gargiulo, Vincenza, Sansone, Teresa, Rea, Giovanna, Artioli, Stefano, Botti, Grazia Isabella, Continisio, Paola, Ferri, Daniela, Masi, Antonio Maria, Risitano, Silvio, Simeone, Rachele, La Sala
In the last years we have seen an ever increasing number of patients with haematologic disorders who need hematopoietic stem cell transplantation (HSCT). The whole sector of HSCT results, infact to be in a continous scientific and technological clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9349b96880ea4517bc0f6d9db7b54c60
https://hdl.handle.net/11380/1128480
https://hdl.handle.net/11380/1128480
Autor:
Daniela Masi, Keila N. Crespo-Llado, Amanda K. Lukens, Roger C. Wiegand, Dyann F. Wirth, Ann Rowley, Jeremy R. Duvall, Richard W. Heidebrecht, Mark E. Fitzgerald, Michael Foley, Adelfa E. Serrano, Nobutaka Kato, Stuart L. Schreiber, Marion Mercier, Benito Munoz, Carol A. Mulrooney, Christina Scherer, Eamon Comer, Maurice D. Lee, Michelle Palmer, Giovanni Muncipinto, Jennifer A. Beaudoin
Publikováno v:
Journal of Medicinal Chemistry
Here, we describe medicinal chemistry that was accelerated by a diversity-oriented synthesis (DOS) pathway, and in vivo studies of our previously reported macrocyclic antimalarial agent that derived from the synthetic pathway. Structure–activity re
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2013, 52 (11), pp.3246-3249. ⟨10.1002/anie.201209446⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2013, 52 (11), pp.3246-3249. ⟨10.1002/anie.201209446⟩
The coupling of (E)-bromofluoroalkenes with various azoles offers a stereocontrolled approach to trisubstituted monofluoroalkene derivatives.
Publikováno v:
ChemInform. 44
The coupling of (E)-bromofluoroalkenes with various azoles offers a stereocontrolled approach to trisubstituted monofluoroalkene derivatives.
Autor:
Stuart L. Schreiber, Jinghua Zhao, Benito Munoz, Amanda K. Lukens, Martin Kramer, Michel Weïwer, Dyann F. Wirth, Menghang Xia, Roger C. Wiegand, Sivaraman Dandapani, Rajarshi Guha, Ken Chih-Chien Cheng, Lisa A. Marcaurelle, Michelle Palmer, Richard W. Heidebrecht, Xin-zhuan Su, Jeremy R. Duvall, Mark E. Fitzgerald, Paul L. Hinkson, Eric H. Ekland, David A. Fidock, Daniela Masi, Christopher P. Austin, Robert H. Barker, Justin Dick, Craig J. Thomas, Jing Yuan, Jennifer A. Beaudoin, Eamon Comer, Michael Foley, Carol A. Mulrooney
Publikováno v:
ACS Medicinal Chemistry Letters
Here, we describe the discovery of a novel antimalarial agent using phenotypic screening of Plasmodium falciparum asexual blood-stage parasites. Screening a novel compound collection created using diversity-oriented synthesis (DOS) led to the initial
Autor:
Pedro Xavier-Elsas, Bianca de Luca, Túlio Queto, Bruno Marques Vieira, Daniela Masid-de-Brito, Elizabeth Chen Dahab, José Carlos Alves Filho, Fernando Q. Cunha, Maria Ignez C. Gaspar-Elsas
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Interleukin- (IL-) 17A, a pleiotropic mediator of inflammation and autoimmunity, potently stimulates bone-marrow neutrophil production. To explore IL-17A effects on eosinopoiesis, we cultured bone-marrow from wild-type mice, or mutants lacking induci
Externí odkaz:
https://doaj.org/article/bcd742229b114de4b8cd21aa276fd858
Autor:
Pedro Xavier-Elsas, Cássio Luiz Coutinho Almeida da Silva, Bruno Marques Vieira, Daniela Masid-de-Brito, Túlio Queto, Bianca de Luca, Thiago Soares de Souza Vieira, Maria Ignez C. Gaspar-Elsas
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Exogenously administered glucocorticoids enhance eosinophil and neutrophil granulocyte production from murine bone-marrow. A hematological response dependent on endogenous glucocorticoids underlies bone-marrow eosinophilia induced by trauma or allerg
Externí odkaz:
https://doaj.org/article/72477e1632114c1a92ad391de0716ddf