Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Daniela Magliulo"'
Autor:
Daniela Magliulo, Matilde Simoni, Carolina Caserta, Cristina Fracassi, Serena Belluschi, Kety Giannetti, Raffaella Pini, Ettore Zapparoli, Stefano Beretta, Martina Uggè, Eleonora Draghi, Federico Rossari, Nadia Coltella, Cristina Tresoldi, Marco J Morelli, Raffaella Di Micco, Bernhard Gentner, Luca Vago, Rosa Bernardi
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-19 (2023)
Abstract One of the defining features of acute myeloid leukemia (AML) is an arrest of myeloid differentiation whose molecular determinants are still poorly defined. Pharmacological removal of the differentiation block contributes to the cure of acute
Externí odkaz:
https://doaj.org/article/2d1702404ed248f580d807aa7c1fabee
Autor:
Daniela Magliulo, Rosa Bernardi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
To cope with hypoxic stress, ancient organisms have developed evolutionally conserved programs centered on hypoxia-inducible transcriptional factors (HIFs). HIFs and their regulatory proteins have evolved as rheostats to adapt cellular metabolism to
Externí odkaz:
https://doaj.org/article/9fdf76c85db24453a731aa481c854a88
Autor:
Roberta Valsecchi, Nadia Coltella, Daniela Magliulo, Lucia Bongiovanni, Lydia Scarfò, Paolo Ghia, Maurilio Ponzoni, Rosa Bernardi
Publikováno v:
Open Biology, Vol 10, Iss 5 (2020)
The transcription factor HIF-1α is overexpressed in chronic lymphocytic leukaemia (CLL), where it promotes leukaemia progression by favouring the interaction of leukaemic cells with protective tissue microenvironments. Here, we tested the hypothesis
Externí odkaz:
https://doaj.org/article/2081f40f9b0f4e9e84088ba97289dcb3
Autor:
Valentina Griggio, Candida Vitale, Maria Todaro, Chiara Riganti, Joanna Kopecka, Chiara Salvetti, Riccardo Bomben, Michele Dal Bo, Daniela Magliulo, Davide Rossi, Gabriele Pozzato, Lisa Bonello, Monia Marchetti, Paola Omedè, Ahad Ahmed Kodipad, Luca Laurenti, Giovanni Del Poeta, Francesca Romana Mauro, Rosa Bernardi, Thorsten Zenz, Valter Gattei, Gianluca Gaidano, Robin Foà, Massimo Massaia, Mario Boccadoro, Marta Coscia
Publikováno v:
Haematologica, Vol 105, Iss 4 (2020)
In chronic lymphocytic leukemia (CLL), the hypoxia-inducible factor 1 (HIF-1) regulates the response of tumor cells to hypoxia and their protective interactions with the leukemic microenvironment. In this study, we demonstrate that CLL cells from TP5
Externí odkaz:
https://doaj.org/article/32e74ba222404eab81c81c9599841830
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy characterized by the accumulation of incompletely differentiated progenitor cells (blasts) in the bone marrow and blood, and by suppression of normal hematopoiesis. It has recen
Externí odkaz:
https://doaj.org/article/65c509b72b0d482bafe3f81c4257b617
Autor:
Daniela Magliulo, Carolina Caserta, Serena Belluschi, Cristina Fracassi, Kety Giannetti, Raffaella Pini, Ettore Zapparoli, Stefano Beretta, Martina Ugge', Matilde Simoni, Eleonora Draghi, Nadia Coltella, Cristina Tresoldi, Marco Morelli, Raffaella Di Micco, Bernhard Gentner, Luca Vago, Rosa Bernardi
Differentiation arrest along the myeloid lineage is a defining feature of acute myeloid leukemia (AML), but its molecular determinants remain poorly defined. Pharmacological removal of the differentiation block leads to leukemia eradication in acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee7e1dad65872432c8933907544be3bf
https://doi.org/10.21203/rs.3.rs-1719682/v1
https://doi.org/10.21203/rs.3.rs-1719682/v1
Publikováno v:
Cancer Research. 83:6552-6552
The zinc finger E-box binding homeobox 1 (ZEB1) transcription factor is a master regulator of the epithelial to mesenchymal transition (EMT). In solid tumors, its overexpression induces EMT, which activates cellular motility and is also associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a348fa241ec30ca9d35bb44b3e13b10
https://doi.org/10.1158/1538-7445.am2023-6552
https://doi.org/10.1158/1538-7445.am2023-6552
Autor:
Daniela Magliulo, Carolina Caserta, Serena Belluschi, Cristina Fracassi, Kety Giannetti, Raffaella Pini, Ettore Zapparoli, Stefano Beretta, Eleonora Draghi, Marco J. Morelli, Raffaella Di Micco, Bernhard Gentner, Luca Vago, Rosa Bernardi
Publikováno v:
Cancer Research. 82:B027-B027
Acute myeloid leukemia (AML) is characterized by epigenetic silencing of differentiation genes and accumulation of aberrant myeloid cells arrested at different stages of myeloid development. The combination of epigenetic and differentiation therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7041b1755156d39e417e65812e83e36a
https://doi.org/10.1158/1538-7445.cancepi22-b027
https://doi.org/10.1158/1538-7445.cancepi22-b027
Autor:
Riccardo Bomben, Paola Omedè, Marta Coscia, Robin Foà, Michele Dal Bo, Mario Boccadoro, Davide Rossi, Gabriele Pozzato, Daniela Magliulo, Giovanni Del Poeta, Valentina Griggio, Rosa Bernardi, Chiara Riganti, Francesca Romana Mauro, Maria Todaro, Gianluca Gaidano, Chiara Salvetti, Massimo Massaia, Joanna Kopecka, Lisa Bonello, Luca Laurenti, Candida Vitale, Thorsten Zenz, Valter Gattei, Monia Marchetti, Ahad Ahmed Kodipad
Publikováno v:
Haematologica
In chronic lymphocytic leukemia (CLL), the hypoxia-inducible factor 1 (HIF-1) regulates the response of tumor cells to hypoxia and their protective interactions with the leukemic microenvironment. In this study, we demonstrate that CLL cells from TP5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb31a4be5ed06525bf909946aab5894d
http://hdl.handle.net/2108/241221
http://hdl.handle.net/2108/241221
Autor:
Daniela Magliulo, Nadia Coltella, Lucia Bongiovanni, Lydia Scarfò, Paolo Ghia, Maurilio Ponzoni, Roberta Valsecchi, Rosa Bernardi
Publikováno v:
Open Biology, Vol 10, Iss 5 (2020)
Open Biology
Open Biology
The transcription factor HIF-1α is overexpressed in chronic lymphocytic leukaemia (CLL), where it promotes leukaemia progression by favouring the interaction of leukaemic cells with protective tissue microenvironments. Here, we tested the hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3cf0e6e1daee88f4813e7e6c59abca
https://doi.org/10.1098/rsob.190262
https://doi.org/10.1098/rsob.190262